Lyu, Ah-Ra Kim, Soo Jeong Park, Min Jung Park, Yong-Ho
Published in
Journal of advanced research
Cisplatin is a life-saving anticancer compound used to treat multiple solid malignant tumors, while it causes permanent hearing loss. There is no known cure, and the FDA has not approved any preventative treatment for cisplatin-based ototoxicity. This study investigated whether the carbon monoxide (CO)-releasing tricarbonyldichlororuthenium (II) di...
Oo, Thura Tun Pratchayasakul, Wasana Chattipakorn, Kenneth Siri-Angkul, Natthapat Choovuthayakorn, Jirachaya Charumporn, Thanapat Ongnok, Benjamin Arunsak, Busarin Chunchai, Titikorn Kongkaew, Aphisek
...
Published in
Molecular neurobiology
High-fat diet consumption for an extended period causes obesity, systemic metabolic disturbance, and brain insulin resistance, resulting in neuroinflammation. Although the beneficial effect of Cyclosorus terminans extract on obesity-related insulin resistance has been demonstrated, little is known about how it affects neuroinflammation and brain in...
Wang, Qingsong Yang, Fan Duo, Kun Liu, Yue Yu, Jianqiang Wu, Qihui Cai, Zhenyu
Published in
Molecular neurobiology
Cerebral ischemia, also known as ischemic stroke, accounts for nearly 85% of all strokes and is the leading cause of disability worldwide. Due to disrupted blood supply to the brain, cerebral ischemic injury is trigged by a series of complex pathophysiological events including excitotoxicity, oxidative stress, inflammation, and cell death. Currentl...
Cheng, Si-Yang Jiang, Lu Wang, Ying Cai, Wei
Published in
Hepatobiliary & pancreatic diseases international : HBPD INT
Intestinal failure-associated liver disease (IFALD) is a common complication of long-term parenteral nutrition that is associated with significant morbidity and mortality. It is mainly characterized by cholestasis in children and steatohepatitis in adults. Unfortunately, there is no effective approach to prevent or reverse the disease. Regulated ce...
Balusu, Sriram; 115980; De Strooper, Bart; 12249;
Although apoptosis, pyroptosis, and ferroptosis have been implicated in AD, none fully explains the extensive neuronal loss observed in AD brains. Recent evidence shows that necroptosis is abundant in AD, that necroptosis is closely linked to the appearance of Tau pathology, and that necroptosis markers accumulate in granulovacuolar neurodegenerati...
Zhang, Caihong Chen, Zixi Shao, Huijing Ma, Ziwen Guan, Rui Yu, Xiaomin Sun, Qianqian Gu, Hang
Published in
Gynecologic and Obstetric Investigation
Objectives: Necroptosis, a form of programmed cell death, can occur in the placenta of patients with preeclampsia (PE). Hydrogen sulfide (H2S) can inhibit necroptosis of human umbilical vein endothelial cells under the high glucose-induced injury. Whether H2S can protect trophoblasts against necroptosis underlying PE has not been elucidated. This s...
Fan, Xue Wang, Yixuan Zhang, Jintao Lin, Hongjin Bai, Zhikun Li, Shu
Published in
Biological trace element research
Selenium (Se) deficiency can affect the expression of microRNA (miRNA) and induce necroptosis, apoptosis, etc., resulting in damage to various tissues and organs. Bisphenol A (BPA) exposure can cause adverse consequences such as oxidative stress, endothelial dysfunction, and atherosclerosis. The toxic effects of combined treatment with Se-deficienc...
Tang, Yining Zhuang, Chunlin
Published in
Bioorganic & medicinal chemistry
Necroptosis is an important form of programmed cell death (PCD), which is mediated by a death receptor and independent of the caspase proteolytic enzyme. Mixed lineage kinase domain-like (MLKL) is the final effector of necroptosis, playing an irreplaceable role in the execution of necroptosis. However, the studies on MLKL inhibitors are in their in...
Wang, Jiale Lu, Cuinan Wang, Jingwen Wang, Ying Bi, Huanjing Zheng, Jin Ding, Xiaoming
Published in
Genomics
Ischemia-reperfusion injury (IRI) is an inevitable pathophysiological phenomenon in kidney transplantation. Necroptosis is an undoubtedly important contributing mechanism in renal IRI. We first screened differentially expressed necroptosis-related genes (DENRGs) from public databases. Eight DENRGs were validated by independent datasets and verified...
Wang, Lvxia Zhang, Yong Huang, Min Yuan, Yiling Liu, Xuehong
Published in
Neurochemical research
Traumatic brain injury (TBI) is a global public safety issue that poses a threat to death, characterized by high fatality rates, severe injuries and low recovery rates. There is growing evidence that necroptosis regulates the pathophysiological processes of a variety of diseases, particularly those affecting the central nervous system. Thus, modera...
