Carlomagno, Simona Setti, Chiara Ortolani, Fulvia Sivori, Simona
Published in
Immunology letters
Pancreatic Ductal Adenocarcinoma (PDAC) is the most frequent pancreatic cancer and represents one of the most aggressive human neoplasms. Typically identified at advance stage disease, most PDAC tumors are unresectable and resistant to standard therapies. The immunosuppressive microenvironment in PDAC impedes tumor control but a greater understandi...
Cui, Yanan Chen, Yanping Zhao, Peiyan Li, Shuang Cheng, Ying Ren, Xiubao
Published in
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Although immunotherapy improves outcomes in extensive-stage small-cell lung cancer (ES-SCLC), the search for biomarkers predicting treatment success is crucial. Natural killer (NK) cells are potential indicators in various cancers, however, their precise role in ES-SCLC prognosis remains unclear. In this retrospective study, 33 patients with ES-SCL...
Zhou, Yi Na, Chuhan Li, Zhigang
Published in
Critical reviews in oncology/hematology
Tumor resistance poses a significant challenge to effective cancer treatment, making it imperative to explore new therapeutic strategies. Recent studies have highlighted the profound involvement of immune cells in the development of tumor resistance. Within the tumor microenvironment, macrophages undergo polarization into the M2 phenotype, thus pro...
Feng, Zhiqian Fu, Junliang Tang, Lili Bao, Chunmei Liu, Honghong Liu, Kai Yang, Tao Yuan, Jin-Hong Zhou, Chun-Bao Zhang, Chao
...
Published in
Hepatology international
The role of neutrophils in hepatitis B virus (HBV) infection has been a subject of debate due to their involvement in antiviral responses and immune regulation. This study aimed to elucidate the neutrophil characteristics in patients with chronic hepatitis B (CHB). Through flow cytometry and ribonucleic acid-sequencing analysis, the phenotypes and ...
Pollenus, Emilie; 123298; Prenen, Fran; 133816; Possemiers, Hendrik; Knoops, Sofie; Mitera, Tania; Lamote, Jochen; De Visscher, Amber; 138318; Vandermosten, Leen; Pham, Thao-Thy; Matthys, Patrick; 9370;
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BACKGROUND: Conventional natural killer (cNK) cells play an important role in the innate immune response by directly killing infected and malignant cells and by producing pro- and anti-inflammatory cytokines. Studies on their role in malaria and its complications have resulted in conflicting results. METHODS: Using the commonly used anti-NK1.1 depl...
Rodrigues Barreto, Inês Monteiro, Andreia Paiva, Artur Fonseca, Ana Mafalda
Published in
Acta neurologica Belgica
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) and has been known as T-cell mediated. However, the contribution of multiple cell types, notably natural killer (NK) cells, has also been reported. To quantify circulating total NK cells and its subpopulations, CD56 dim and bright, and to characterize the ...
Kaur, Sukhbir Roberts, David D
Published in
Seminars in cell & developmental biology
Thrombospondin-1 is a secreted matricellular glycoprotein that modulates cell behavior by interacting with components of the extracellular matrix and with several cell surface receptors. Its presence in the extracellular matrix is induced by injuries that cause thrombospondin-1 release from platelets and conditions including hyperglycemia, ischemia...
Saadh, Mohamed J Rasulova, Irodakhon Khalil, Mohamed Farahim, Farha Sârbu, Ioan Ciongradi, Carmen Iulia Omar, Thabit Moath Alhili, Ahmed Jawad, Mahmood Jasem Hani, Thamer
...
Published in
Pathology, research and practice
In the immunological surveillance against cancer, natural killer (NK) cells are essential effectors that help eradicate altered cells. The complex interactions that occur between NK cells and the tumor microenvironment (TME) are thoroughly examined in this review. The review examines how cytokine stimulation affects NK cell activation, focusing on ...
Neo, Shi Yong Oliveira, Mariana M S Tong, Le Chen, Yi Chen, Ziqing Cismas, Sonia Burduli, Nutsa Malmerfelt, Anna Teo, Joey Kay Hui Lam, Kong-Peng
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Published in
Journal of experimental & clinical cancer research : CR
Inflammation in the eye is often associated with aggravated ocular diseases such as uveal melanoma (UM). Poor prognosis of UM is generally associated with high potential of metastatic liver dissemination. A strong driver of metastatic dissemination is the activation of the epithelial-mesenchymal transition (EMT) regulating transcription factor ZEB1...
Boyles, Christabel
Platinum chemotherapeutics remain standard of care for many cancer patients, including high grade serous ovarian cancer. It is becoming clear that chemotherapy can initiate adaptive immune responses to the cancer, however, it remains unclear to what extent innate Natural Killer (NK) cells contribute. Using two syngeneic models (UPK10 and ID8p53-/-)...
