Aslan, Erdem Adem, Sevki
Published in
Journal of biochemical and molecular toxicology
Dihydrofolate reductase (DHFR) plays a fundamental role in cellular metabolism and cell growth. Inhibition of this enzyme will cause a decrease in the amount of folate that occurs in many metabolic processes, and the deficiency of which may cause various diseases. This study investigated the effects of some drugs and phenolic compounds on DHFR acti...
Cerella, Claudia Gaigneaux, Anthoula Dicato, Mario Diederich, Marc
Published in
Cancer Letters
Cells reprogram their metabolism very early during carcinogenesis; this event is critical for the establishment of other cancer hallmarks. Many oncogenes and tumor suppressor genes control metabolism by interplaying with the existing nutrient-sensing intracellular pathways. Mammalian target of rapamycin, mTOR, is emerging as a collector and sorter ...
Michael Schnekenburger Dicato, Mario Marc Diederich
Published in
Biotechnology Advances
Carcinogenesis is a complex and multistep process that involves the accumulation of successive transformational events driven by genetic mutations and epigenetic alterations that affect major cellular processes and pathways such as proliferation, differentiation, invasion and survival. Massive deregulation of all components of the epigenetic machin...
Orlikova, Barbora Legrand, Noémie Panning, Jana Dicato, Mario Diederich, Marc
Published in
Cancer treatment and research
Over the centuries, plant extracts have been used to treat various diseases. Until now, natural products have played an important role in anticancer therapy as there are more than 500 compounds from terrestrial and marine plants or microorganisms, which have antioxidant, antiproliferative, or antiangiogenic properties and are therefore able to redu...
Marie-Hélène Teiten Francois Gaascht Dicato, Mario Marc Diederich
Published in
Biochemical Pharmacology
Since centuries, natural compounds from plants, animals and microorganisms were used in medicinal traditions to treat various diseases without a solid scientific basis. Recent studies have shown that plants that were used or are still used in the medieval European medicine are able to provide relieve for many diseases including cancer. Here we summ...
Teiten, Marie-Hélène Gaascht, François Dicato, Mario Diederich, Marc
Published in
Biochemical Pharmacology
Since centuries, natural compounds from plants, animals and microorganisms were used in medicinal traditions to treat various diseases without a solid scientific basis. Recent studies have shown that plants that were used or are still used in the medieval European medicine are able to provide relieve for many diseases including cancer. Here we summ...
Sawadogo, Wamtinga Richard Schumacher, Marc Teiten, Marie-Hélène Dicato, Mario Diederich, Marc
Published in
Biochemical Pharmacology
Traditional pharmacopeia is strongly involved in the continuous search for the well being of African populations. The World Health Organization (WHO) estimates that 80% of the population of developing countries relies on traditional medicine for their primary care needs. Medicinal plants are the major resource of this folk medicine where several sp...
Marie-Hélène Teiten Francois Gaascht Dicato, Mario Marc Diederich
Published in
Current Pharmaceutical Biotechnology
The aberrant activation of the wingless (Wnt) signaling pathway is a key element involved in carcinogenesis as Wnt regulates a variety of cellular processes including proliferation, differentiation, survival, apoptosis and cell motility. Upon Wnt receptor activation, the canonical "Wnt/beta-catenin" as well as the non canonical "Wnt/planar cell pol...
Sarmah, Rajeev
Published in
Bioinformation
Dexamethasone (DEX) an anti-inflamatory 9-fluoro-glucocorticoid, activates the cytosolic glucocorticoid receptor (GR) binding to its Ligand Binding Domain (LBD). The GR-ligand complex then translocates to the nucleus and binds to the Glucocorticoid Response Element (GRE) resulting up-regulation of target gene expression of anti-inflamatory proteins...
Margarida Costa João Costa-Rodrigues Maria Helena Fernandes Piedade Barros Vitor Vasconcelos Rosário Martins
Marine cyanobacteria have been considered a rich source of secondary metabolites with potential biotechnological applications, namely in the pharmacological field. Chemically diverse compounds were found to induce cytoxicity, anti-inflammatory and antibacterial activities. The potential of marine cyanobacteria as anticancer agents has however been ...
