Nahass, George R Sun, Yuanzi Xu, Yong Batchelor, Mark Reilly, Madeleine Benilova, Iryna Kedia, Niraja Spehar, Kevin Sobott, Frank Sessions, Richard B
...
Published in
Journal of molecular biology
Alpha-synuclein (α-syn) fibrils, a major constituent of the neurotoxic Lewy Bodies in Parkinson's disease, form via nucleation dependent polymerization and can replicate by a seeding mechanism. Brazilin, a small molecule derived from red cedarwood trees in Brazil, has been shown to inhibit the fibrillogenesis of amyloid-beta (Aβ) and α-syn as well ...
Awasthi, Ankita Kumar, Pharvendra Srikanth, Chittur V. Sahi, Shakti Puria, Rekha
Published in
Pathology & Oncology Research
Colorectal cancer (CRC) is one of the most prevalent cancers diagnosed worldwide. Despite recent advances, resistance to cytotoxic and targeted therapy remains one of the greatest challenges in long-term management of colorectal cancer therapy. Recently established role of mTOR signaling in proliferation of CRC has incited for evaluation of mTOR ki...
Petuškovs, Andrejs Shubin, Kirill
Published in
Chemistry of Heterocyclic Compounds
Modern synthetic methods for the preparation of 2-benzazepines are presented, covering past 15 years of research. Current microreview includes a variety of chemical transformations, applicability of which was demonstrated on a substantial scope of substrates.
Koifman, O. I. Novakov, I. A.
Published in
Russian Journal of Organic Chemistry
Liu, Haidan Liu, Kangdong Huang, Zunnan Park, Chan-Mi Thimmegowda, N R Jang, Jae-Hyuk Ryoo, In-Ja He, Long Kim, Sun-Ok Oi, Naomi
...
Published in
The Journal of biological chemistry
Chrysin (5,7-dihydroxyflavone), a natural flavonoid widely distributed in plants, reportedly has chemopreventive properties against various cancers. However, the anticancer activity of chrysin observed in in vivo studies has been disappointing. Here, we report that a chrysin derivative, referred to as compound 69407, more strongly inhibited EGF-ind...
Gaascht, François Dicato, Mario Diederich, Marc
Published in
Frontiers in Oncology
Chemoprevention uses natural or synthetic molecules without toxic effects to prevent and/or block emergence and development of diseases including cancer. Many of these natural molecules modulate mitogenic signals involved in cell survival, apoptosis, cell cycle regulation, angiogenesis, or on processes involved in the development of metastases occu...
Ginsburg, Hagai Deharo, Eric
Published in
Malaria Journal
Natural compounds, mostly from plants, have been the mainstay of traditional medicine for thousands of years. They have also been the source of lead compounds for modern medicine, but the extent of mining of natural compounds for such leads decreased during the second half of the 20th century. The advantage of natural compounds for the development ...
BONESI, Marco Sylvie Michel
FR
Alaniya, M. D. Gigoshvili, T. I. Kavtaradze, N. Sh. Lavoi, Serge Pichette, Andre Mshvildadze, V. D.
Published in
Chemistry of Natural Compounds
Rybina, A. V. Shepelevich, I. S. Talipov, R. F. Galin, F. Z. Spirikhin, L. V.
Published in
Chemistry of Natural Compounds
