Cardellini, Jacopo Ridolfi, Andrea Donati, Melissa Giampietro, Valentina Severi, Mirko Brucale, Marco Valle, Francesco Bergese, Paolo Montis, Costanza Caselli, Lucrezia
Journal of colloid and interface science
Although promising for biomedicine, the clinical translation of inorganic nanoparticles (NPs) is limited by low biocompatibility and stability in biological fluids. A common strategy to circumvent this drawback consists in disguising the active inorganic core with a lipid bilayer coating, reminiscent of the structure of the cell membrane to redefin...
L'abstract è presente nell'allegato / the abstract is in the attachment
Zhang, Rui Kiessling, Fabian Lammers, Twan Pallares, Roger M
Drug delivery and translational research
Gold nanoparticles display unique physicochemical features, which can be useful for therapeutic purposes. After two decades of preclinical progress, gold nanoconstructs are slowly but steadily transitioning into clinical trials. Although initially thought to be "magic golden bullets" that could be used to treat a wide range of diseases, current con...
González-Durruthy, Michael Concu, Riccardo Osmari Vendrame, Laura F Ortiz Martins, Mirkos Zanella, Ivana Ruso, Juan Manuel Dias Soeiro Cordeiro, Maria Natália
Current topics in medicinal chemistry
Herein, molecular docking approaches and DFT ab initio simulations were combined for the first time, to study the key interactions of cyclodextrins (CDs: α-CD, β-CD, and γ-CD) family with potential pharmacological relevance and the multidrug resistance P-gp protein toward efficient drug-delivery applications. The treatment of neurological disorders...
Silveira, Paulo César Lock Rodrigues, Matheus Scarpatto Gelain, Daniel Pens de Oliveira, Jade
Metabolic brain disease
Nanotechnology is an emerging and expanding technology worldwide. The manipulation of materials on a nanometric scale generates new products with unique properties called nanomaterials. Due to its significant expansion, nanotechnology has been applied in several fields of study, including developing materials for biomedical applications, i.e., nano...
Hua, Susan Lye, Ephraem C
Drug delivery and translational research
General surgical procedures on the gastrointestinal tract are commonly performed worldwide. Surgical resections of the stomach, small intestine, or large intestine can have a significant impact on the anatomy and physiological environment of the gastrointestinal tract. These physiological changes can affect the effectiveness of orally administered ...
Yosri, Nermeen Alsharif, Sultan M Xiao, Jianbo Musharraf, Syed G Zhao, Chao Saeed, Aamer Gao, Ruichang Said, Noha S Di Minno, Alessandro Daglia, Maria
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Arctium lappa L. is a medicinal edible homologous plant, commonly known as burdock or bardana, which belongs to the Asteraceae family. It is widely distributed throughout Northern Asia, Europe, and North America and has been utilized for hundreds of years. The roots, fruits, seeds, and leaves of A. lappa have been extensively used in traditional Ch...
Soleymani-Goloujeh, Mehdi Hosseini, Samaneh Baghaban Eslaminejad, Mohamadreza
Advances in experimental medicine and biology
Stem cells are valuable tools in regenerative medicine because they can generate a wide variety of cell types and tissues that can be used to treat or replace damaged tissues and organs. However, challenges related to the application of stem cells in the scope of regenerative medicine have urged scientists to utilize nanomedicine as a prerequisite ...
Wei, Hao Jiang, Dawei Yu, Bo Ni, Dalong Li, Mengting Long, Yin Ellison, Paul A Siamof, Cerise M Cheng, Liang Barnhart, Todd E
Acute kidney injury (AKI) leads to unacceptably high mortality due to difficulties in timely intervention and less efficient renal delivery of therapeutic drugs. Here, a series of polyvinylpyrrolidone (PVP)-curcumin nanoparticles (PCurNP) are designed to meet the renal excretion threshold (∼45 kDa), presenting a controllable delivery nanosystem for...
Costanzo, Manuela Malatesta, Manuela
Methods in molecular biology (Clifton, N.J.)
Visualizing nanoparticles made of organic material (e.g., polysaccharides, proteins, non-osmiophilic lipids) inside cells and tissues at transmission electron microscopy is a difficult task due to the intrinsic weak electron density of these nanoconstructs, which makes them hardly distinguishable in the biological environment. We describe here a si...