Zhang, Shilei Wang, Jingfeng Wang, Lulan Aliyari, Saba Cheng, Genhong
Most deaths from the COVID-19 pandemic are due to acute respiratory distress syndrome (ARDS)-related respiratory failure. Cytokine storms and oxidative stress are the major players in ARDS development during respiratory virus infections. However, it is still unknown how oxidative stress is regulated by viral and host factors in response to SARS-CoV...
Torcinaro, Alessio Cappetta, Donato De Santa, Francesca Telesca, Marialucia Leigheb, Massimiliano Berrino, Liberato Urbanek, Konrad De Angelis, Antonella Ferraro, Elisabetta
Published in
Metabolites
Sarcopenia is defined as the loss of muscle mass associated with reduced strength leading to poor quality of life in elderly people. The decline of skeletal muscle performance is characterized by bioenergetic impairment and severe oxidative stress, and does not always strictly correlate with muscle mass loss. We chose to investigate the ability of ...
Medina, Narda Rodriguez-Tudela, Juan Luis Pérez, Juan Carlos Mercado, Danicela Bonilla, Oscar Arathoon, Eduardo Alastruey-Izquierdo, Ana
Published in
Microorganisms
Cryptococcal disease is an important opportunistic infection among people living with HIV. The cryptococcal antigen (CrAg) can be detected before the clinical onset of meningitis and its screening is recommended. Here, we evaluated CrAg frequency, and describe the epidemiological characteristics and mortality at 180 days in a cohort of HIV patients...
Choi, Bo-Hyun Ryoo, Ingeun Sim, Kyeong Hwa Ahn, Hyeon-Jin Lee, Youn Ju Kwak, Mi-Kyoung
Published in
Biomolecules & therapeutics
Hyaluronic acid (HA), a ligand of CD44, accumulates in some types of tumors and is responsible for tumor progression. The nuclear factor erythroid 2-like 2 (NRF2) regulates cytoprotective genes and drug transporters, which promotes therapy resistance in tumors. Previously, we showed that high levels of CD44 are associated with NRF2 activation in ca...
gonnella;, roberta
PEL is a rare B cell lymphoma associated with KSHV that mainly arises in immune-deficient individuals. The search for new drugs to treat this cancer is still ongoing given its aggressiveness and the poor response to chemotherapies. In this study, we found that DMF, a drug known for its anti-inflammatory properties which is registered for the treatm...
lisa, anna
Induction of heme oxygenase 1 (HO-1) favors immune-escape in BRAFV600 melanoma cells treated with Vemurafenib/PLX4032 under standard cell culture conditions. However, the oxygen tension under standard culture conditions (~18 kPa O2) is significantly higher than the physiological oxygen levels encountered in vivo. In addition, cancer cells in vivo a...
zhou;, yi qi meng
Acute kidney injury (AKI) induced by cisplatin (CP), a first-line anticancer drug for chemotherapy, is common. To date, there is an urgent need to find effective treatments to reduce the nephrotoxicity caused by CP. Meanwhile, the restoration of mitochondrial dysfunction shows potential to be used as an adjunct to conventional therapeutic strategie...
Li, Na Du, Hang Mao, Lejiao Xu, Ge Zhang, Mengling Fan, Yinzhen Dong, Xiaomei Zheng, Lijun Wang, Bin Qin, Xia
...
Published in
Journal of Nanobiotechnology
CuONPs exposure activates NRF2 signaling in vascular endothelial cells and mouse thoracic aorta. KEAP1 is dispensable for NRF2 activation in CuONPs-treated vascular endothelial cells. CuONPs-induced autophagy facilitates NRF2 activation in vascular endothelial cells and mouse thoracic aorta. Autophagy and ubiquitin–proteasome reciprocally regulate ...
Zhang, Shunhao Duan, Sining Xie, Zhuojun Bao, Wanlin Xu, Bo Yang, Wenbin Zhou, Lingyun
Published in
Frontiers in Pharmacology
The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) and its negative regulator kelch-like ECH-associated protein 1 (KEAP1) regulate various genes involved in redox homeostasis, which protects cells from stress conditions such as reactive oxygen species and therefore exerts beneficial effects on suppression of carcinogenesis....
Yin, Bo-Feng Li, Zhi-Ling Yan, Zi-Qiao Guo, Zheng Liang, Jia-Wu Wang, Qian Zhao, Zhi-Dong Li, Pei-Lin Hao, Rui-Cong Han, Meng-Yue
...
Published in
Stem Cell Research & Therapy
Background Repairing radiation-induced bone injuries remains a significant challenge in the clinic, and few effective medicines are currently available. Psoralen is a principal bioactive component of Cullen corylifolium (L.) Medik and has been reported to have antitumor, anti-inflammatory, and pro-osteogenesis activities. However, less information ...