Peukert, Konrad Steinhagen, Folkert Fox, Mario Feuerborn, Caroline Schulz, Susanne Seeliger, Benjamin Schuss, Patrick Schneider, Matthias Frede, Stilla Sauer, Andrea
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Published in
Respiratory Research
BackgroundInhalation of dust containing silica particles is associated with severe pulmonary inflammation and lung injury leading to chronic silicosis including fibrotic remodeling of the lung. Silicosis represents a major global health problem causing more than 45.000 deaths per year. The inflammasome-caspase-1 pathway contributes to the developme...
Digby, Zsofi Tourlomousis, Panagiotis Rooney, James Boyle, Joseph P Bibo-Verdugo, Betsaida Pickering, Robert J Webster, Steven J Monie, Thomas Hopkins, Lee J Kayagaki, Nobuhiko
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Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity in host immune genes across species affect pathogen carriage is poorly understood. Here, we describe a progressive evolutionary downregulation of pathogen-sensing inflammasome pathway...
Prigozhin, Daniil M Krasileva, Ksenia V
The evolution of recognition specificities by the immune system depends on the generation of receptor diversity and on connecting the binding of new antigens with the initiation of downstream signaling. In plant immunity, the innate Nucleotide-Binding Leucine-Rich Repeat (NLR) receptor family enables antigen binding and immune signaling. In this st...
Gao, C Xu, H Huang, J Sun, B Zhang, F Savage, Z Duggan, C Yan, T Wu, C-H Wang, Y
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In plants and animals, nucleotide-binding leucine-rich repeat (NLR) proteins are intracellular immune sensors that recognize and eliminate a wide range of invading pathogens. NLR-mediated immunity is known to be modulated by environmental factors. However, how pathogen recognition by NLRs is influenced by environmental factors such as light remains...
Adachi, H Contreras, MP Harant, A Wu, C-H Derevnina, L Sakai, T Duggan, C Moratto, E Bozkurt, TO Maqbool, A
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The molecular codes underpinning the functions of plant NLR immune receptors are poorly understood. We used in vitro Mu transposition to generate a random truncation library and identify the minimal functional region of NLRs. We applied this method to NRC4—a helper NLR that functions with multiple sensor NLRs within a Solanaceae receptor network. T...
Zhang, Yongliang Song, Gaoyuan Lal, Neeraj K Nagalakshmi, Ugrappa Li, Yuanyuan Zheng, Wenjie Huang, Pin-Jui Branon, Tess C Ting, Alice Y Walley, Justin W
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Nucleotide-binding leucine-rich repeat (NLR) immune receptors play a critical role in defence against pathogens in plants and animals. However, we know very little about NLR-interacting proteins and the mechanisms that regulate NLR levels. Here, we used proximity labeling (PL) to identify the proteome proximal to N, which is an NLR that confers res...
Hung, Adriana M Tsuchida, Yohei Nowak, Kristen L Sarkar, Sudipa Chonchol, Michel Whitfield, Victoria Salas, Natjalie Dikalova, Anna Yancey, Patricia G Huang, Jiansheng
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Published in
Clinical journal of the American Society of Nephrology : CJASN
Systemic inflammation modulates cardiovascular disease risk and functionality of HDL in the setting of CKD. Whether interventions that modify systemic inflammation can improve HDL function in CKD is unknown. We conducted a post hoc analysis of two randomized, clinical trials, IL-1 trap in participants with GFR 15-59 ml/min per 1.73 m2 (study A) and...
Qi, Tiancong Seong, Kyungyong Thomazella, Daniela PT Kim, Joonyoung Ryan Pham, Julie Seo, Eunyoung Cho, Myeong-Je Schultink, Alex Staskawicz, Brian J
Effector-triggered immunity (ETI) in plants involves a large family of nucleotide-binding leucine-rich repeat (NLR) immune receptors, including Toll/IL-1 receptor-NLRs (TNLs) and coiled-coil NLRs (CNLs). Although various NLR immune receptors are known, a mechanistic understanding of NLR function in ETI remains unclear. The TNL Recognition of XopQ 1...
Chen, Shisheng Zhang, Wenjun Bolus, Stephen Rouse, Matthew N Dubcovsky, Jorge
Wheat stem rust, caused by Puccinia graminis f. sp. tritici (Pgt), is a devastating foliar disease. The Ug99 race group has combined virulence to most stem rust (Sr) resistance genes deployed in wheat and is a threat to global wheat production. Here we identified a coiled-coil, nucleotide-binding leucine-rich repeat protein (NLR) completely linked ...
Heller, Jens Clavé, Corinne Gladieux, Pierre Saupe, Sven J Glass, N Louise
In plants and metazoans, intracellular receptors that belong to the NOD-like receptor (NLR) family are major contributors to innate immunity. Filamentous fungal genomes contain large repertoires of genes encoding for proteins with similar architecture to plant and animal NLRs with mostly unknown function. Here, we identify and molecularly character...
