Azimi, Parham Keshavarz, Zahra Lahaie Luna, Marianne Cedeno Laurent, Jose Guillermo Vallarino, Jose Christiani, David C Allen, Joseph G
Published in
International journal of environmental research and public health
Up to 95% of the liquid volume in an e-cigarette consists of propylene glycol. Previous research has shown that propylene glycol can generate diacetyl and formaldehyde when heated. New research shows that propylene glycol can also generate methylglyoxal, an alpha di-carbonyl compound recently shown to cause epithelial necrosis at even lower concent...
Bousquet, Jean Cristol, Jean-Paul Czarlewski, Wienczyslawa Anto, Josep M. Martineau, Adrian Haahtela, Tari Fonseca, Susana C. Iaccarino, Guido Blain, Hubert Fiocchi, Alessandro
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Published in
Clinical and Translational Allergy
There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) an...
Zhang, Qian Bastard, Paul Liu, Zhiyong Le Pen, Jérémie Moncada-Velez, Marcela Chen, Jie Ogishi, Masato Sabli, Ira K. D. Hodeib, Stephanie Korol, Cecilia
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Clinical outcome upon infection with SARS-CoV-2 ranges from silent infection to lethal COVID-19. We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern TLR3- and IRF7-dependent type I interferon (IFN) immunity to influenza virus, in 659 patients with life-threatening COVID-19 pneumon...
Zhang, Qian; Bastard, Paul; Liu, Zhiyong; Le Pen, Jeremie; Moncada-Velez, Marcela; Chen, Jie; Ogishi, Masato; Sabli, Ira KD; Hodeib, Stephanie; Korol, Cecilia;
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Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern Toll-like receptor 3 (TLR3)- and interferon regulatory ...
Hastir, Jean-Francois Delbauve, Sandrine Larbanoix, Lionel Germanova, Desislava Goyvaerts, Cleo Allard, Justine Laurent, Sophie Breckpot, Karine Beschin, Alain Guilliams, Martin
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Partial hepatectomy (PH) is the main treatment for early-stage hepatocellular carcinoma (HCC). Yet, a significant number of patients undergo recursion of the disease that could be linked to the fate of innate immune cells during the liver regeneration process. In this study, using a murine model, we investigated the impact of PH on HCC development ...
Panagiotakopoulou, Vasiliki; Ivanyuk, Dina; De Cicco, Silvia; Haq, Wadood; Arsic, Aleksandra; Yu, Cong; Messelodi, Daria; Oldrati, Marvin; Schoendorf, David C; Perez, Maria-Jose;
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Parkinson's disease-associated kinase LRRK2 has been linked to IFN type II (IFN-γ) response in infections and to dopaminergic neuronal loss. However, whether and how LRRK2 synergizes with IFN-γ remains unclear. In this study, we employed dopaminergic neurons and microglia differentiated from patient-derived induced pluripotent stem cells carrying L...
Lo Bello, F Hansbro, PM Donovan, C Coppolino, I Mumby, S Adcock, IM Caramori, G
Introduction Chronic obstructive pulmonary disease (COPD) is a lung disease characterized by chronic bronchitis, emphysema, and remodeling. Its prevalence is increasing worldwide; however, there are few effective therapies, and none of the treatments currently available prevent the progression of the disease or target all of the hallmark features. ...
Herbelet, Sandrine Rodenbach, Arthur De Paepe, Boel De Bleecker, Jan L.
Published in
International Journal of Molecular Sciences
In Duchenne muscular dystrophy (DMD), the activation of proinflammatory and metabolic cellular pathways in skeletal muscle cells is an inherent characteristic. Synthetic glucocorticoid intake counteracts the majority of these mechanisms. However, glucocorticoids induce burdensome secondary effects, including hypertension, arrhythmias, hyperglycemia...
Anand, P
Inflammasomes are multi‐protein complexes that regulate the cleavage of cysteine protease caspase‐1, secretion of inflammatory cytokines, and induction of inflammatory cell death, pyroptosis. Several members of the nod‐like receptor family assemble inflammasome in response to specific ligands. An exception to this is the NLRP3 inflammasome which is...
Zhang, Huaiyong Pan, Shuqin Zhang, Keying Michiels, Joris Zeng, Qiufeng Ding, Xuemei Wang, Jianping Peng, Huanwei Bai, Jie Xuan, Yue
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Published in
Microorganisms
Growing concern for public health and food safety has prompted a special interest in developing nutritional strategies for removing waterborne and foodborne pathogens, including Salmonella . Strong links between manganese (Mn) and intestinal barrier or immune function hint that dietary Mn supplementation is likely to be a promising approach to limi...
