Herbelet, Sandrine Rodenbach, Arthur De Paepe, Boel De Bleecker, Jan L.
Published in
International Journal of Molecular Sciences
In Duchenne muscular dystrophy (DMD), the activation of proinflammatory and metabolic cellular pathways in skeletal muscle cells is an inherent characteristic. Synthetic glucocorticoid intake counteracts the majority of these mechanisms. However, glucocorticoids induce burdensome secondary effects, including hypertension, arrhythmias, hyperglycemia...
Anand, P
Inflammasomes are multi‐protein complexes that regulate the cleavage of cysteine protease caspase‐1, secretion of inflammatory cytokines, and induction of inflammatory cell death, pyroptosis. Several members of the nod‐like receptor family assemble inflammasome in response to specific ligands. An exception to this is the NLRP3 inflammasome which is...
Zhang, Huaiyong Pan, Shuqin Zhang, Keying Michiels, Joris Zeng, Qiufeng Ding, Xuemei Wang, Jianping Peng, Huanwei Bai, Jie Xuan, Yue
...
Published in
Microorganisms
Growing concern for public health and food safety has prompted a special interest in developing nutritional strategies for removing waterborne and foodborne pathogens, including Salmonella . Strong links between manganese (Mn) and intestinal barrier or immune function hint that dietary Mn supplementation is likely to be a promising approach to limi...
Martens, Arne Priem, Dario Hoste, Esther Vetters, Jessica Rennen, Sofie Catrysse, Leen Voet, Sofie Deelen, Laura Sze, Mozes Vikkula, Hanna
...
Published in
Nature Immunology
van Loo and colleagues provide insights into the action of the anti-inflammatory protein A20. The ZnF7 and ZnF4 ubiquitin-binding domains of A20 are both required to suppress inflammatory signaling and cell death; however, these zinc fingers operate via distinct mechanisms.
Tipanee, Jaitip; Di Matteo, Mario; 57607; Tulalamba, Warut; Samara-Kuko, Ermira; Keirsse, Jiri; Van Ginderachter, Jo A; Chuah, Marinee Khim; Vanden Driessche, Thierry;
We established a semi-high-throughput in vivo screening platform using hyperactive piggyBac (hyPB) transposons (designated as PB-miR) to identify microRNAs (miRs) that inhibit hepatocellular carcinoma (HCC) development in vivo, following miR overexpression in hepatocytes. PB-miRs encoding six different miRs from the miR-17-92 cluster and nine miRs ...
Hassannia, Behrouz Logie, Emilie Vandenabeele, Peter Vanden Berghe, Tom Vanden Berghe, Wim
Published in
Biochemical pharmacology
Despite the recent successes of targeted cancer immuno-therapies, drug resistance and disease relapse remain a huge burden in cancer patient treatment. This has fueled renewed interest in natural product discovery to identify new pharmacophores for innovative cancer drug development. Reverse pharmacology approaches of Withania somnifera leaves and ...
Sanchez Garrido, J Slater, SL Clements, A Shenoy, A Frankel, G
Enteric pathogen-host interactions occur at multiple interfaces,includingthe intestinal epitheliumand deeper organsof the immune system. Microbial ligands and activities are detected by host sensorsthat elicit a range of immune responses. Membrane-bound Toll-Like Receptors (TLRs) and cytosolic inflammasomepathways are key signal transducers that tr...
Ono, M
The transcription factor Foxp3 controls the differentiation and function of regulatory T-cells (Treg). Studies in the past decades identified numerous Foxp3-interacting protein partners. However, it is still not clear how Foxp3 produces the Treg-type transcriptomic landscape through cooperating with its partners. Here I show the current understandi...
Maelfait, Jonathan Liverpool, Layal Rehwinkel, Jan
Palomer, X Silvia Roman-Azcona, M Pizarro-Delgado, J Planavila, A Villarroya, F Valenzuela-Alcaraz, B Crispi, F Sepulveda-Martinez, A Miguel-Escalada, I Ferrer, J
...
Sirtuin 3 (SIRT3) is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress. Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances. In this study, we investigated the role of SIRT3 in inflammation and fibro...
