Chela-Alvarez, Xenia Bulilete, Oana García-Buades, M Esther Ferrer-Perez, Victoria A Llobera-Canaves, Joan
Published in
International journal of environmental research and public health
Tourism is the main economic sector in the Balearic Islands (Spain) and hotel housekeepers (HHs) are a large occupational group, in which stress is becoming a major issue. This study aims at exploring in-depth factors perceived as stressors by HHs and key-informants, and their effects on work-life balance (WLB). A qualitative design with phenomenol...
Saha, Chinmoy Horst-Kreft, Deborah Kross, Inez Louwen, Rogier
The zoonotic human pathogen Campylobacter jejuni is known for its ability to induce DNA-damage and cell death pathology in humans. The molecular mechanism behind this phenomenon involves nuclear translocation by Cas9, a nuclease in C. jejuni (CjeCas9) that is the molecular marker of the Type II CRISPR-Cas system. However, it is unknown via which ce...
Wang, J Zhang, W J Xiong, W Lu, W H Zheng, H Y Zhou, X Yuan, J
Published in
Human & experimental toxicology
Previous studies indicated that exposure to fine particulate matter (PM2.5) was related to pulmonary inflammatory diseases through activation of nuclear factor kappa B (NF-κB) signaling pathway to trigger cytokine secretions in human lung carcinoma cells. To investigate the potential mechanisms underlying expression of cytokines via activated NF-κB...
Yang, Jin Won Murray, Ben Barbier-Torres, Lucia Liu, Ting Liu, Zhenqiu Yang, Heping Fan, Wei Wang, Jiaohong Li, Yuan Seki, Ekihiro
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Prohibitin 1 (PHB1) is a mitochondrial chaperone whose expression is dysregulated in cancer. In liver cancer, PHB1 acts as a tumor suppressor, but the mechanisms of tumor suppression are incompletely understood. Here we aimed to determine PHB1 target genes to better understand how PHB1 influences liver tumorigenesis. Using RNA-Seq analysis, we foun...
Grosicka-Maciąg, Emilia Kurpios-Piec, Dagmara Woźniak, Katarzyna Kowalewski, Cezary Szumiło, Maria Drela, Nadzieja Kiernozek, Ewelina Suchocki, Piotr Rahden-Staroń, Iwonna
Published in
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
Selol, an organic selenitetrigliceride formulation containing selenium at +4 oxidation level, has been suggested as anticancer drug. One of the causes of several diseases including cancer may be inflammation. This study aimed at determining the activity of Selol via measuring its effect on reactive oxygen species (ROS) generation, nuclear factor ka...
Meloni, Laura Verstrepen, Lynn Kreike, Marja Staal, Jens Driege, Yasmine Afonina, Inna S. Beyaert, Rudi
Published in
Molecules
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is an intracellular cysteine protease (paracaspase) that plays an integral role in innate and adaptive immunity. The phenothiazine mepazine has been shown to inhibit the proteolytic activity of MALT1 and is frequently used to study its biological role. MALT1 has recently bee...
Jennings, Elliott Esposito, Diego Rittinger, Katrin Thurston, Teresa L M
Published in
The Journal of biological chemistry
The closely related type III secretion system zinc metalloprotease effector proteins GtgA, GogA, and PipA are translocated into host cells during Salmonella infection. They then cleave nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) transcription factor subunits, dampening activation of the NF-κB signaling pathway and thereby sup...
kim, k h e kim, j kwun, j lee, j y bach, t t eum, sang choi, j y cho, s kim, s j jeong, s i
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Ethnopharmacological relevance: Although Spilanthes acmella has been used to relieve inflammation, fever, pain, or infection in traditional Asian medicine, experimental evidence supporting these functions is scarce. Here, we examined an anti-inflammatory function and a possible underlying mechanism of S. acmella Murray (SAM). Materials and method: ...
Xu, Yu Tan, Hor-Yue Li, Sha Wang, Ning Feng, Yibin
Published in
The American journal of Chinese medicine
Panax notoginseng (P. notoginseng) is a well-known and commonly used Chinese herbal medicine in Asian countries. As one of the major species in the Panax genus, it has a distinct chemical composition and medical application compared with other species. P. notoginseng attracts attention and interest due to its potential therapeutic effects not only ...
Kim, Tae Ho Choi, Jun-Yong Kim, Kyun Ha Kwun, Min Jung Han, Chang-Woo Won, Ran Lee, Jung Ju Kim, Jong-In Joo, Myungsoo
Published in
The American journal of Chinese medicine
Hominis placenta (HP), a dried human placenta, has been known to target liver, lung, or kidney meridians, improving the functions associated with these meridians in traditional Chinese or Asian medicine (TCM). Since recent studies implicate an HP extract in suppressing inflammation, we investigated whether an aqueous HP extract can ameliorate infla...
