Alkhalefa, Noura Khaliel, Samy Tahoon, Abdelnaby Shaban, Hanan Magouz, Asmaa Ghabban, Hanaa Lokman, Maha S. Elmahallawy, Ehab Kotb
Published in
Frontiers in Veterinary Science
The Newcastle disease virus (NDV) is considered a serious threat to global poultry production. Despite the availability of vaccines, it remains a major devastating epidemic responsible for great economic losses. The development of novel virus-controlling strategies is therefore an urgent need. The present study investigated for the first time the a...
krishan, bal
Various toll-like receptor (TLR) agonists have shown potential as adjuvants with different vaccines in both human and livestock species, including chickens. Our previous studies on combination of lipopolysaccharide (LPS; TLR4 agonist) and resiquimod (R-848; TLR7 agonist) showed the synergistic up-regulation of pro-inflammatory Th1 and Th2 cytokines...
Puro, Kekunguu Sen, Arnab
Published in
Frontiers in Veterinary Science
Lin, Zhenyu Wang, Jie Zhang, Nian Yi, Jianshu Wang, Zhaofei Ma, Jingjiao Wang, Hengan Yan, Yaxian Qian, Kun Sun, Jianhe
...
Published in
Veterinary Research
Interferon regulatory factors (IRFs) play a key role in many aspects of immune response, and IRF1, IRF3, and IRF7 are positive regulators of IFN induction in mammals. However, IRF3, as the most critical regulatory factor in mammals, is naturally absent in birds, which attracts us to study the functions of other members of the avian IRF family. In t...
Mngumi, Elifuraha Barnabas Bunuma, Emmanuel
Published in
Tropical Animal Health and Production
Newcastle disease virus (NDV) causes significant losses of poultry in Tanzania. Like in many African countries, the regular surveillance of NDV is important for the control of disease. The objective of this study was to determine seroprevalence of NDV in unvaccinated backyard poultry in Bahi and Njombe districts of Tanzania over the rainy (May) and...
Bu, Yawen Teng, Qingyuan Feng, Delan Sun, Lu Xue, Jia Zhang, Guozhong
Published in
Microbiology Spectrum
Newcastle disease virus (NDV) fusion protein mediates the virus’s fusion activity, which is a determinant of NDV pathogenicity. The ectodomain of the F protein is known to have a major impact on fusion, and several reports have also indicated the role of the cytoplasmic tail (CT) in viral entry, F protein cleavage, and fusion, which are regulated b...
liu;, weiwei
The chicken is a model animal for the study of evolution, immunity and development. In addition to their use as a model organism, chickens also represent an important agricultural product. Pathogen invasion has already been shown to modulate the expression of hundreds of genes, but the role of alternative splicing in avian virus infection remains u...
Meher, Mirza Mienur Jahan, Nusrat Afrin, Marya
Published in
Macedonian Veterinary Review
Newcastle disease (ND) is a highly contagious viral disease. This study was conducted to determine the antibody titer in Japanese quails following vaccination against ND and feed-supplementation with vitamin-C, probiotics and antibiotic-growth-promoters. Forty Japanese quails were equally grouped in four groups (A1 to A4) and were vaccinated by LaS...
Nan, Fu Long Zhang, He Nan, Wen Long Xie, Chang Zhan Ha, Zhuo Chen, Xing Xu, Xiao Hong Qian, Jing Qiu, Xu Sheng Ge, Jin Ying
...
Published in
Veterinary microbiology
The V protein of Newcastle disease virus (NDV) has been shown to inhibit the secretion of interferon (IFN) during infection, which is responsible for the promotion of NDV pathogenicity. However, the ability of the V protein to suppress host innate immunity is not well understood. In this study, we explored the function of V protein and its relation...
Lara-Puente, Jesús Horacio Carreño, Juan Manuel Sun, Weina Suárez-Martínez, Alejandro Ramírez-Martínez, Luis Quezada-Monroy, Francisco Paz-De la Rosa, Georgina Vigueras-Moreno, Rosalía Singh, Gagandeep Rojas-Martínez, Oscar
...
Published in
mBio
Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were developed in record time and show excellent efficacy and effectiveness against coronavirus disease 2019 (COVID-19). However, currently approved vaccines cannot meet the global demand. In addition, none of the currently used vaccines is administered intranasally to po...
