Salari, Nader Darvishi, Niloufar Mansouri, Kamran Ghasemi, Hooman Hosseinian-Far, Melika Darvishi, Fateme Mohammadi, Masoud
Published in
BMC Endocrine Disorders
BackgroundNon-alcoholic fatty liver disease (NAFLD) is a common disorder that is known to be the leading cause of chronic liver disease worldwide. This study aims to systematically review and meta-analyze the association between PNPLA3 rs738409 polymorphism and non-alcoholic fatty liver.MethodsFollowing a systematic review and meta-analysis method,...
Fourman, Lindsay T Stanley, Takara L Zheng, Isabel Pan, Chelsea S Feldpausch, Meghan N Purdy, Julia Aepfelbacher, Julia Buckless, Colleen Tsao, Andrew Corey, Kathleen E
...
Published in
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Nonalcoholic fatty liver disease (NAFLD) affects more than one-third of people living with human immunodeficiency virus (HIV). Nonetheless, its natural history is poorly understood, including which patients are most likely to have a progressive disease course. We leveraged a randomized trial of the growth hormone-releasing hormone analogue tesamore...
Lee, Seoung-Woo Baek, Su-Min Kang, Kyung-Ku Lee, A-Rang Kim, Tae-Un Choi, Seong-Kyoon Roh, Yoon-Seok Hong, Il-Hwa Park, Sang-Joon Kim, Tae-Hwan
...
Published in
The American journal of pathology
Despite the increasing clinical importance of nonalcoholic fatty liver disease (NAFLD), little is known about its underlying pathogenesis or specific treatment. The senescence marker protein 30 (SMP30), which regulates the biosynthesis of vitamin C in many mammals except primates and humans, was recently recognized as a gluconolactonase. However, t...
Beisner, Julia Filipe Rosa, Louisa Kaden-Volynets, Valentina Stolzer, Iris Günther, Claudia Bischoff, Stephan C.
Published in
Frontiers in Immunology
Defects in the mucosal barrier have been associated with metabolic diseases such as obesity and non-alcoholic fatty liver disease (NAFLD). Mice fed a Western-style diet (WSD) develop obesity and are characterized by a diet-induced intestinal barrier dysfunction, bacterial endotoxin translocation and subsequent liver steatosis. To examine whether in...
Errafii, Khaoula Al-Akl, Neyla S. Khalifa, Olfa Arredouani, Abdelilah
Published in
Journal of Translational Medicine
Background and aimsThe hallmark of non-alcoholic fatty liver disease (NAFLD) is the excessive hepatic lipid accumulation. Currently, no pharmacotherapy exists for NAFLD. However, the glucagon-like peptide-1 receptor agonists have recently emerged as potential therapeutics. Here, we sought to identify the long non-coding RNAs (LncRNAs) associated wi...
Luo, Zupeng Hu, Hailong Liu, Siqi Zhang, Zhiwang Li, Yixing Zhou, Lei
Published in
RNA biology
Translational regulation plays a critical role in gene expression. However, there are few genome-wide studies on translational regulation in non-alcoholic fatty liver disease (NAFLD), which is a severe non-communicable epidemic worldwide. In this study, we performed RNC-mRNA (mRNAs bound to ribosome-nascent chain complex) sequencing and mRNA sequen...
Lei, Zhi-Xiong Wang, Juan-Juan Li, Kang Liu, Ping
Published in
The Kaohsiung journal of medical sciences
This study aims to discover the role of Homocysteine-induced ER protein (Herp) deficiency in high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD). After 8 weeks of feeding with normal-fat diet (NFD) or HFD, WT (wild type) and Herp-/- mice were measured for the body weight, liver weight and serum biochemical parameters. HE, Oil Red O...
Bissig-Choisat, Beatrice Alves-Bezerra, Michele Zorman, Barry Ochsner, Scott A Barzi, Mercedes Legras, Xavier Yang, Diane Borowiak, Malgorzata Dean, Adam M York, Robert B
...
Background & aimsThe accumulation of neutral lipids within hepatocytes underlies non-alcoholic fatty liver disease (NAFLD), which affects a quarter of the world's population and is associated with hepatitis, cirrhosis, and hepatocellular carcinoma. Despite insights gained from both human and animal studies, our understanding of NAFLD pathogenesis r...
Vivero, Ariel Ruz, Manuel Rivera, Matías Miranda, Karen Sacristán, Camila Espinosa, Alejandra Codoceo, Juana Inostroza, Jorge Vásquez, Karla Pérez, Álvaro
...
Published in
Biological trace element research
Type 2 diabetes mellitus (T2D) is a metabolic disorder caused by chronic hyperglycemia due to a deficiency in the secretion and/or action of insulin. Zinc (Zn) supplementation and strength exercise increases insulin signaling. We evaluate the effect of Zn supplementation and strength exercise on insulin resistance in the liver of rats with diet-ind...
Eletreby, Rasha Abdellatif, Zeinab Gaber, Yasmine Ramadan, Ahmed Ahmad, Naglaa Khattab, Hany Said, Mohamed Saad, Yasmin
Published in
Egyptian Liver Journal
BackgroundWe evaluated the validity of some non-invasive scores and ultrasound findings to predict fibrosis and steatosis in a cohort of NAFLD patients who underwent liver biopsy. Ninety-seven NAFLD patients were enrolled and classified into NASH (66) and simple steatosis groups (31) based on liver biopsy. ROC curves were constructed for Fibrosis-4...
