Published in Korean Journal of Chemical Engineering
The use of oxidoreductases as biocatalysts for industrial production of valuable compounds has a strong demand for NADP. Herein, we prepared superparamagnetic NAD kinase catalyst to synthesize NADP in vitro. First, Fe3O4 particles were synthesized through a solvothermal method, followed by the chemical modification with epichloro-hydrin, iminodiace...
The Internet of things (IoT) has unlimited potential to empower the lives of everyone. IoT devices increasingly appear in homes and power smart and connected communities. Related user experience design efforts must involve and consider people with disabilities, including the world’s rapidly aging population of seniors. They must be able to use IoT ...
© 2019 The Author(s). Background: Numerous studies have shown that stress induction and genetic engineering can effectively increase lipid accumulation, but lead to a decrease of growth in the majority of microalgae. We previously found that elevated CO2 concentration increased lipid productivity as well as growth in Phaeodactylum tricornutum, alon...
SARM1(sterile-α andTIR motif containing protein 1)is responsible forNAD+depletion duringWalleriandegenerationassociated with neuropathies. Plant NLR (nucleotide-binding leucine-rich repeat) immune receptors recognize pathogen effector proteins and trigger localized cell death to restrict pathogen infection. Both processes depend on closely related ...
Published in FEBS open bio
The enzyme 5,10-methylenetetrahydrofolate dehydrogenase (MTHFD) is essential for the production of certain amino acids (glycine, serine, and methionine) and nucleic acids (thymidylate and purine). Here, we identified a cDNA encoding this enzyme from the silkworm Bombyx mori. The recombinant B. mori MTHFD (bmMTHFD) expressed in Escherichia coli reco...
The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) protects against redox stress by providing reducing equivalents to antioxidants such as glutathione and thioredoxin. NADPH levels decline with aging in several tissues, but whether this is a major driving force for the aging process has not been well established. Global or neur...
Published in The Science of the total environment
This study examines co-located aerosol and precipitation chemistry data between 2010 and 2016 at Pinnacles National Monument ~65 km east of the coastline in central California. Positive matrix factorization analysis of the aerosol composition data revealed seven distinct pollutant sources: aged sea salt (25.7% of PM2.5), biomass burning (24.2% of P...
ADP-ribosylation is a unique posttranslational modification catalyzed by poly(ADP-ribose) polymerases (PARPs) using NAD+ as ADP-ribose donor. PARPs play an indispensable role in DNA damage repair and small molecule PARP inhibitors have emerged as potent anticancer drugs. However, to date, PARP inhibitor treatment has been restricted to patients wit...
Published in Journal of Atmospheric Chemistry
Changes in the frequency of precipitation as a result of a changing climate, as well as anthropogenic induced deposition of nitrogen (N), both have the potential to alter grassland productivity and diversity. Central U.S. weather patterns are dominated by three major air mass trajectories including regional sources from the Gulf of Mexico (marine t...
Lösliche, NAD(P)+-abhängige [NiFe]-Hydrogenasen („Soluble Hydrogenase“, SH) katalysieren die reversible Spaltung von H2 in jeweils zwei Elektronen und Protonen sowie die damit gekoppelte Reduktion des Pyridinnukleotid-Kofaktors. Die beiden Reaktionen erfolgen in zwei unterschiedlichen Modulen, dem Hydrogenasemodul HoxHY, das das H2-spaltende aktive...
