Al-Thani, Hessa Lee, Jon
Published in
SN Operations Research Forum
We present an open-source R package (MESgenCov v 0.1.0) for temporally fitting multivariate precipitation chemistry data and extracting a covariance matrix for use in the MESP (maximum-entropy sampling problem). We provide multiple functionalities for modeling and model assessment. The package is tightly coupled with NADP/NTN (National Atmospheric ...
Liu, Changxia Yang, Yadi Gao, Huafeng Bai, Xiaoshuang Li, Zheng-Jun
Published in
Korean Journal of Chemical Engineering
The use of oxidoreductases as biocatalysts for industrial production of valuable compounds has a strong demand for NADP. Herein, we prepared superparamagnetic NAD kinase catalyst to synthesize NADP in vitro. First, Fe3O4 particles were synthesized through a solvothermal method, followed by the chemical modification with epichloro-hydrin, iminodiace...
Rochford, John
The Internet of things (IoT) has unlimited potential to empower the lives of everyone. IoT devices increasingly appear in homes and power smart and connected communities. Related user experience design efforts must involve and consider people with disabilities, including the world’s rapidly aging population of seniors. They must be able to use IoT ...
Wu, S Gu, W Huang, A Li, Y Kumar, M Lim, PE Huan, L Gao, S Wang, G
© 2019 The Author(s). Background: Numerous studies have shown that stress induction and genetic engineering can effectively increase lipid accumulation, but lead to a decrease of growth in the majority of microalgae. We previously found that elevated CO2 concentration increased lipid productivity as well as growth in Phaeodactylum tricornutum, alon...
Diaz, Julia M Plummer, Sydney Hansel, Colleen M Andeer, Peter F Saito, Mak A McIlvin, Matthew R
Reactive oxygen species (ROS) like superoxide drive rapid transformations of carbon and metals in aquatic systems and play dynamic roles in biological health, signaling, and defense across a diversity of cell types. In phytoplankton, however, the ecophysiological role(s) of extracellular superoxide production has remained elusive. Here, the mechani...
Horsefield, Shane Burdett, Hayden Zhang, Xiaoxiao Manik, Mohammad K Shi, Yun Chen, Jian Qi, Tiancong Gilley, Jonathan Lai, Jhih-Siang Rank, Maxwell X
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SARM1(sterile-α andTIR motif containing protein 1)is responsible forNAD+depletion duringWalleriandegenerationassociated with neuropathies. Plant NLR (nucleotide-binding leucine-rich repeat) immune receptors recognize pathogen effector proteins and trigger localized cell death to restrict pathogen infection. Both processes depend on closely related ...
Wang, Liang Wei Shen, Hongying Veiga Nobre, Luis Ersing, Ina Paulo, Joao A Trudeau, Stephen Wang, Zhonghao Smith, Nicholas A Ma, Yijie Reinstadler, Bryn
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Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B-cell lymphomas. How EBV remodels metabolic pathways to support rapid B-cell outgrowth remains largely unknown. To gain insights, primary human B-cells were profiled by tandem-mass-tag based proteomics at rest and at 9 time points after infection. >8000 host and 29 viral protein...
Ortíz, Cecilia Botti, Horacio Buschiazzo, Alejandro Comini, Marcelo A
Published in
Journal of molecular biology
Glucose-6-phosphate dehydrogenase (G6PDH) is the key enzyme supplying reducing power (NADPH) to the cells, by oxidation of glucose-6-phosphate (G6P), and in the process providing a precursor of ribose-5-phosphate. G6PDH is also a virulence factor of pathogenic trypanosomatid parasites. To uncover the biochemical and structural features that disting...
Larson, Steven B Jones, Jesse A McPherson, Alexander
Published in
Acta crystallographica. Section F, Structural biology communications
An iron-containing alcohol dehydrogenase (FeADH) from the hyperthermophilic archaeon Thermococcus thioreducens was crystallized in unit cells belonging to space groups P21, P212121 and P43212, and the crystal structures were solved at 2.4, 2.1 and 1.9 Å resolution, respectively, by molecular replacement using the FeADH from Thermotoga maritima (Sch...
Haque, Mohammad R Higashiura, Akifumi Nakagawa, Atsushi Hirowatari, Aiko Furuya, Shigeki Yamamoto, Kohji
Published in
FEBS open bio
The enzyme 5,10-methylenetetrahydrofolate dehydrogenase (MTHFD) is essential for the production of certain amino acids (glycine, serine, and methionine) and nucleic acids (thymidylate and purine). Here, we identified a cDNA encoding this enzyme from the silkworm Bombyx mori. The recombinant B. mori MTHFD (bmMTHFD) expressed in Escherichia coli reco...
