Sayers, Sophie R Beavil, Rebecca L Fine, Nicholas H F Huang, Guo C Choudhary, Pratik Pacholarz, Kamila J Barran, Perdita E Butterworth, Sam Mills, Charlotte E Cruickshank, J Kennedy
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Published in
Diabetologia
Progressive decline in functional beta cell mass is central to the development of type 2 diabetes. Elevated serum levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) are associated with beta cell failure in type 2 diabetes and eNAMPT immuno-neutralisation improves glucose tolerance in mouse models of diabetes. Despite this, the ...
Yamaguchi, Shintaro Franczyk, Michael P Chondronikola, Maria Qi, Nathan Gunawardana, Subhadra C Stromsdorfer, Kelly L Porter, Lane C Wozniak, David F Sasaki, Yo Rensing, Nicholas
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Published in
Proceedings of the National Academy of Sciences of the United States of America
Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme for cellular energy metabolism. The aim of the present study was to determine the importance of brown and white adipose tissue (BAT and WAT) NAD+ metabolism in regulating whole-body thermogenesis and energy metabolism. Accordingly, we generated and analyzed adipocyte-specific nicotinam...
Gao, Rongsui Wei, Wenhui Hassan, Bachar H Li, Jun Deng, Jiaoyu Feng, Youjun
Published in
eLife
Nicotinamide adenine dinucleotide (NAD+) is an indispensable cofactor in all domains of life, and its homeostasis must be regulated tightly. Here we report that a Nudix-related transcriptional factor, designated MsNrtR (MSMEG_3198), controls the de novo pathway of NAD+biosynthesis in M. smegmatis, a non-tuberculosis Mycobacterium. The integrated ev...
Byun, Jaemin Oka, Shin-Ichi Imai, Nobushige Huang, Chun-Yang Ralda, Guersom Zhai, Peiyong Ikeda, Yoshiyuki Ikeda, Shohei Sadoshima, Junichi
Published in
American journal of physiology. Heart and circulatory physiology
The heart requires high-energy production, but metabolic ability declines in the failing heart. Nicotinamide phosphoribosyl-transferase (Nampt) is a rate-limiting enzyme in the salvage pathway of nicotinamide adenine dinucleotide (NAD) synthesis. NAD is directly involved in various metabolic processes and may indirectly regulate metabolic gene expr...
Horsefield, Shane Burdett, Hayden Zhang, Xiaoxiao Manik, Mohammad K Shi, Yun Chen, Jian Qi, Tiancong Gilley, Jonathan Lai, Jhih-Siang Rank, Maxwell X
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SARM1(sterile-α andTIR motif containing protein 1)is responsible forNAD+depletion duringWalleriandegenerationassociated with neuropathies. Plant NLR (nucleotide-binding leucine-rich repeat) immune receptors recognize pathogen effector proteins and trigger localized cell death to restrict pathogen infection. Both processes depend on closely related ...
Dziubalska-Kołaczyk, Katarzyna
Published in
Folia Linguistica
This paper shows how preferability measures can help to explain the cross-linguistic distribution of consonant clusters, their acquisition, as well as aspects of their diachronic development. Phonological preferability is measured in terms of cluster size and Net Auditory Distance, which interact with morphological complexity and frequency. Predict...
Jasek, Karin Kubatka, Peter Samec, Marek Liskova, Alena Smejkal, Karel Vybohova, Desanka Bugos, Ondrej Biskupska-Bodova, Kristina Bielik, Tibor Zubor, Pavol
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Published in
Biomolecules
The modulation of the activity of DNA methyltransferases (DNMTs) represents a crucial epigenetic mechanism affecting gene expressions or DNA repair mechanisms in the cells. Aberrant modifications in the function of DNMTs are a fundamental event and part of the pathogenesis of human cancer. Phytochemicals, which are biosynthesized in plants in the f...
Zha, Siyuan Wang, Fei Li, Zhen Ma, Zhiyuan Yang, Ling Liu, Fang
Published in
Cell cycle (Georgetown, Tex.)
Objective: Atherosclerosis involves endothelial injury caused by oxidative stress. Endothelial progenitor cells (EPCs) play important roles in preventing the early stages of atherosclerosis. Meanwhile, poly (ADP-ribose) polymerase 1 (PARP1) utilizes nicotinamide adenine dinucleotide (NAD+) to repair DNA damage. PARP1 overactivation results in exces...
Lesot, Philippe
Based on pionneering work reported in the 1980’s by Martin and co-workers, experimental investigation of the site-specific, natural (2H/1H) isotope fractionation in bioproducts by natural abundance deuterium 1D-NMR (NAD 1D-NMR) spectroscopy is the method of choice to understand the enzymatic mechanisms leading to their synthesis or transformation, ...
Mendelsohn, Andrew R Larrick, James W
Published in
Rejuvenation research
During human aging, decrease of NAD+ levels is associated with potentially reversible dysfunction in the liver, kidney, skeletal and cardiac muscle, endothelial cells, and neurons. At the same time, the number of senescent cells, associated with damage or stress that secretes proinflammatory factors (SASP or senescence-associated secretory phenotyp...
