Published in Herz
Elevated levels of the extracellular matrix glycoprotein osteopontin (OPN) may be detected in both myocardium and plasma under various pathological conditions affecting the heart. Several studies demonstrated increased plasma OPN levels in patients with heart failure due to dilated cardiomyopathy (DCM), while other studies showed high OPN expressio...
SUMMARY OBJECTIVE: To investigate the protective effect and mechanism of dexmedetomidine (Dex) on perioperative myocardial injury in patients with Stanford type-A aortic dissection (AD). METHODS: Eighty-six patients with Stanford type-A AD were randomly divided into Dex and control groups, with 43 cases in each group. During the surgery, the contro...
Modified Look-Locker inversion recovery (MOLLI) using a 5s(3s)3s scheme is robust to tachycardia, but some errors are occasionally observed in myocardial T1 mapping. We sought to evaluate the relationship between measurement errors in T1 mapping and heart rate (HR) using a confidence map. We enrolled 69 male patients with normal native T1 values of...
Published in Computer methods and programs in biomedicine
deep learning algorithms have not been successfully used for the left ventricle (LV) detection in echocardiographic images due to overfitting and vanishing gradient descent problem. This research aims to increase accuracy and improves the processing time of the left ventricle detection process by reducing the overfitting and vanishing gradient prob...
Published in Histochemistry and cell biology
Obesity due to high calorie intake induces cardiac hypertrophy and dysfunction, thus contributing to cardiovascular morbidity and mortality. Recent studies in aging suggest that oral supplementation with the natural polyamine spermidine has a cardioprotective effect. Here, the hypothesis was tested that spermidine or voluntary activity alone or in ...
The Purkinje network is the rapid conduction system in the heart. It ensures the physiological spread of the electrical wave in the ventricles. From the mathematical viewpoint the model is made up of a degenerate parabolic reaction diffusion system coupled with an ODE system. We derive existence, uniqueness and some regularity results. The excitati...
Published in Biomaterials
Despite significant efforts in the study of cardiovascular diseases (CVDs), they persist as the leading cause of mortality worldwide. Considerable research into human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) has highlighted their immense potential in the development of in vitro human cardiac tissues for broad mechanistic, therapeutic...
Published in European Heart Journal
Aims Coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been associated with cardiovascular features of myocardial involvement including elevated serum troponin levels and acute heart failure with reduced ejection fraction. The cardiac pathological changes in these patients with COVID-19 have...
Age (>70 years), case fatality rate (CFR,10.2%) and coexisting conditions, particularly cardiovascular disease (CFR,10.5%) and hypertension (CFR,6.0%), are independent predictors of adverse outcome for 45,000 COVID-19 patients in China [1]. A consensus has emerged that SARS-CoV-2 uses the same ‘receptor’ as SARS-CoV, the angiotensin converting enzy...
Published in Biomedical engineering letters
Mathematical modelling in biomechanics of infarcted left ventricle (LV) serves as an indispensable tool for remodelling mechanism exploration, LV biomechanical property estimation and therapy assessment after myocardial infarction (MI). However, a review of mathematical modelling after MI has not been seen in the literature so far. In the paper, a ...
