Khattar, Nikkita Triebswetter, Curtis Kiely, Matthew Ferrucci, Luigi Resnick, Susan M Spencer, Richard G Bouhrara, Mustapha
Published in
NeuroImage
Myelin loss and iron accumulation are cardinal features of aging and various neurodegenerative diseases. Oligodendrocytes incorporate iron as a metabolic substrate for their myelin synthesis and maintenance. An emerging hypothesis in Alzheimer's disease research suggests that myelin breakdown releases substantial stores of iron that may accumulate,...
Sutiwisesak, Rujapope Burns, Terry C Rodriguez, Moses Warrington, Arthur E
Published in
Expert opinion on investigational drugs
Multiple sclerosis (MS) is the most common inflammatory disease of the central nervous system (CNS). Demyelination, the main pathology in MS, contributes to clinical symptoms and long-term neurological deficits if left untreated. Remyelination, the natural repair of damaged myelin by cells of the oligodendrocyte lineage occurs in MS, but eventually...
Zarekiani, Parand Breur, Marjolein Wolf, Nicole I. de Vries, Helga E. van der Knaap, Marjo S. Bugiani, Marianna
Published in
Acta Neuropathologica Communications
The blood–brain barrier is a dynamic endothelial cell barrier in the brain microvasculature that separates the blood from the brain parenchyma. Specialized brain endothelial cells, astrocytes, neurons, microglia and pericytes together compose the neurovascular unit and interact to maintain blood–brain barrier function. A disturbed brain barrier fun...
Yan, Zhengjian Chu, Lei Jia, Xiaojiong Lin, Lu Cheng, Si
Published in
Cell & Bioscience
IntroductionStem cell therapy using neural progenitor cells (NPCs) shows promise in mitigating the debilitating effects of spinal cord injury (SCI). Notably, myelin stimulates axonal regeneration from mammalian NPCs. This led us to hypothesize that myelin-associated proteins may contribute to axonal regeneration from NPCs.MethodsWe conducted an R-b...
Boshkovski, Tommy Kocarev, Ljupco Cohen-Adad, Julien Mišić, Bratislav Lehéricy, Stéphane Stikov, Nikola Mancini, Matteo
Published in
Network Neuroscience
In the present work, we show that by using a myelin-sensitive measure we can complement the diffusion MRI-based connectivity and provide a different picture of the brain organization. We show that the R1-weighted average distribution does not follow the same trend as the number of streamlines strength distribution, and the two connectomes exhibit d...
Sanchez-Molina, Paula Almolda, Beatriz Benseny-Cases, Núria González, Berta Perálvarez-Marín, Alex Castellano, Bernardo
Published in
Neurobiology of aging
Physiological aging is characterized by an imbalance of pro-inflammatory and anti-inflammatory mediators leading to neuroinflammation. Microglial cells, which are highly regulated by the local microenvironment, undergo specific changes depending upon the brain area during aging. The aim of this study was to evaluate the influence of age over microg...
Lazari, Alberto Lipp, Ilona
Published in
Neuroimage
Recent years have seen an increased understanding of the importance of myelination in healthy brain function and neuropsychiatric diseases. Non-invasive microstructural magnetic resonance imaging (MRI) holds the potential to expand and translate these insights to basic and clinical human research, but the sensitivity and specificity of different MR...
Casella, Chiara Kleban, Elena Rosser, Anne E. Coulthard, Elizabeth Rickards, Hugh Fasano, Fabrizio Metzler-Baddeley, Claudia Jones, Derek K.
Published in
NeuroImage : Clinical
White matter (WM) alterations have been identified as a relevant pathological feature of Huntington’s disease (HD). Increasing evidence suggests that WM changes in this disorder are due to alterations in myelin‐associated biological processes. Multi-compartmental analysis of the complex gradient-echo MRI signal evolution in WM has been shown to qua...
Rivera, Andrea D. Chacon-De-La-Rocha, Irene Pieropan, Francesca Papanikolau, Maria Azim, Kasum Butt, Arthur M.
Published in
Pflugers Archiv
White matter (WM) is a highly prominent feature in the human cerebrum and is comprised of bundles of myelinated axons that form the connectome of the brain. Myelin is formed by oligodendrocytes and is essential for rapid neuronal electrical communication that underlies the massive computing power of the human brain. Oligodendrocytes are generated t...
Johnson, Eileanoir B. Parker, Christopher S. Scahill, Rachael I. Gregory, Sarah Papoutsi, Marina Zeun, Paul Osborne-Crowley, Katherine Lowe, Jessica Nair, Akshay Estevez-Fraga, Carlos
...
Published in
EBioMedicine
Background Pathological processes in Huntington's disease (HD) begin many years prior to symptom onset. Recently we demonstrated that in a premanifest cohort approximately 24 years from predicted disease onset, despite intact function, there was evidence of subtle neurodegeneration. Here, we use novel imaging techniques to determine whether macro- ...
