Malara, Mariagiovanna Lutz, Anne-Kathrin Incearap, Berra Bauer, Helen Friedericke Cursano, Silvia Volbracht, Katrin Lerner, Joanna Janina Pandey, Rakshita Delling, Jan Philipp Ioannidis, Valentin
...
Published in
Cellular and Molecular Life Sciences
Mutations or deletions of the SHANK3 gene are causative for Phelan–McDermid syndrome (PMDS), a syndromic form of autism spectrum disorders (ASDs). We analyzed Shank3Δ11(−/−) mice and organoids from PMDS individuals to study effects on myelin. SHANK3 was found to be expressed in oligodendrocytes and Schwann cells, and MRI analysis of Shank3Δ11(−/−) ...
Wang, Xi-Xi Cui, Ling-Ling Gan, Si-Fei Zhang, Ze-Ru Xiao, Jing Li, Chen-Hong Luo, Fang
Published in
The journal of pain
Opioid-induced hyperalgesia (OIH) is a problem associated with prolonged use of opioids in chronic pain management, and its effective treatment has been hampered by lack of mechanistic evidence. Oligodendrocytes have recently been linked with several pain-related diseases; however, little is known its role in OIH. The prelimbic medial prefrontal co...
Anand, Chaitali Brandmaier, Andreas M. Lynn, Jonathan Arshad, Muzamil Stanley, Jeffrey A. Raz, Naftali
Published in
Neuroimage. Reports
We used intra-class effect decomposition (ICED) to evaluate the reliability of myelin water fraction (MWF) and geometric mean T2 relaxation time (geomT2IEW) estimated from a multi-echo MRI sequence. Our evaluation addressed test-retest reliability, with and without participant re-positioning, for seven commonly assessed white matter tracts: anterio...
Scalabrino, Giuseppe
Published in
Cellular and molecular neurobiology
This article reviews the wealth of papers dealing with the different effects of epidermal growth factor (EGF) on oligodendrocytes, astrocytes, neurons, and neural stem cells (NSCs). EGF induces the in vitro and in vivo proliferation of NSCs, their migration, and their differentiation towards the neuroglial cell line. It interacts with extracellular...
Jordans, Silvia Hardt, Robert Becker, Ivonne Winter, Dominic Wang-Eckhardt, Lihua Eckhardt, Matthias
Published in
Molecular Neurobiology
PNS and CNS myelin contain large amounts of galactocerebroside and sulfatide with 2-hydroxylated fatty acids. The underlying hydroxylation reaction is catalyzed by fatty acid 2-hydroxylase (FA2H). Deficiency in this enzyme causes a complicated hereditary spastic paraplegia, SPG35, which is associated with leukodystrophy. Mass spectrometry-based pro...
Poggi, Giulia Albiez, Jamie Pryce, Christopher R.
Published in
Neurobiology of Stress
• CSS decreases the density of proliferative OPCs in mPFC and BLA. • CSS increases the density of mature oligodendrocyte in BLA. • CSS increases myelin content in mPFC, and not in BLA. • CSS increases myelin thickness in mPFC and not in BLA.
Economou, Maria; 119203; Billiet, Thibo; Wouters, Jan; 10113; Ghesquiere, Pol; 4944; Vanderauwera, Jolijn; Vandermosten, Maaike; 48220;
Diffusion-weighted imaging studies have repeatedly shown that white matter correlates with reading throughout development. However, the neurobiological interpretation of this relationship is constrained by the limited microstructural specificity of diffusion imaging. A critical component of white matter microstructure is myelin, which can be invest...
Wilczynski, Ella Sasson, Efrat Eliav, Uzi Navon, Gil Nevo, Uri
Published in
Magma (New York, N.Y.)
Magnetization EXchange (MEX) sequence measures a signal linearly dependent on the myelin proton fraction by selective suppression of water magnetization and a recovery period. Varying the recovery period enables extraction of the percentile fraction of myelin bound protons. We aim to demonstrate the MEX sequence sensitivity to the fraction of proto...
Miletić, Steven Bazin, Pierre-Louis Isherwood, Scott J S Keuken, Max C Alkemade, Anneke Forstmann, Birte U
Published in
NeuroImage
The human subcortex comprises hundreds of unique structures. Subcortical functioning is crucial for behavior, and disrupted function is observed in common neurodegenerative diseases. Despite their importance, human subcortical structures continue to be difficult to study in vivo. Here we provide a detailed account of 17 prominent subcortical struct...
Morris, Sarah R Frederick, Rebecca MacKay, Alex L Laule, Cornelia Michal, Carl A
Published in
Journal of magnetic resonance (San Diego, Calif. : 1997)
Inhomogeneous magnetization transfer (ihMT) is a novel MRI technique used to measure white matter myelination in the brain and spinal cord. In the brain, ihMT has a strong orientation dependence which is likely to arise from the anisotropy of dipolar couplings between protons on oriented lipids in the myelin bilayers. We measured the orientation de...
