Computational and Structural Biotechnology Journal
Quantification of similarities between protein sequences or DNA/RNA strands is a (sub-)task that is ubiquitously present in bioinformatics workflows, and is usually accomplished by pairwise comparisons of sequences, utilizing simple ( e.g. percent identity) or more intricate concepts ( e.g. substitution scoring matrices). Complex tasks (such as clu...
Therapeutic Innovation & Regulatory Science
In new drug development process, one of the most important milestones for a drug candidate is to establish Proof of Concept (PoC) at early Phase II stage. Among many challenges in PoC clinical trial design and analysis, the application of multiplicity comparison procedures (MCP) is frequently discussed when multiple doses or drugs are included in o...
Journal of Cheminformatics
Despite being a central concept in cheminformatics, molecular similarity has so far been limited to the simultaneous comparison of only two molecules at a time and using one index, generally the Tanimoto coefficent. In a recent contribution we have not only introduced a complete mathematical framework for extended similarity calculations, (i.e. com...
Journal of advanced research
The multiparental population provides us the chance to identify superior alleles controlling a trait for genetic improvement. Genome wide association studies at bin level (bin-GWAS) are expected to be more power in QTL mapping than GWAS at SNP level (SNP-GWAS). This study is to estimate genetic effects of QTL conferring grain appearance quality in ...
Journal of pediatric surgery
In pediatric surgery research, the issue of multiple comparisons commonly arises when there are multiple patient or experimental groups being compared two at a time on an outcome of interest. Performing multiple statistical comparisons increases the likelihood of finding a false positive result when there truly are no statistically significant grou...
The multiple testing problem arises not only when there are many voxels or vertices in an image representation of the brain, but also when multiple contrasts of parameter estimates (that represent hypotheses) are tested in the same general linear model. We argue that a correction for this multiplicity must be performed to avoid excess of false posi...
BMC Medical Research Methodology
BackgroundBayesian adaptive methods are increasingly being used to design clinical trials and offer several advantages over traditional approaches. Decisions at analysis points are usually based on the posterior distribution of the treatment effect. However, there is some confusion as to whether control of type I error is required for Bayesian desi...
Behavior Research Methods
Nonparametric multiple comparisons are a powerful statistical inference tool in psychological studies. In this paper, we review a rank-based nonparametric multiple contrast test procedure (MCTP) and propose an improvement by allowing the procedure to accommodate various effect sizes. In the review, we describe relative effects and show how utilizin...
Image, graphical abstract
BackgroundMulti-arm designs provide an effective means of evaluating several treatments within the same clinical trial. Given the large number of treatments now available for testing in many disease areas, it has been argued that their utilisation should increase. However, for any given clinical trial there are numerous possible multi-arm designs t...