Pain or gain?
Published in eLife
The 3D structures of a membrane protein called TMEM120A suggest that it may act as an enzyme in fat metabolism rather than as an ion channel that senses mechanical pain.
Synthesized HMGB1 peptide attenuates liver inflammation and suppresses fibrosis in mice
...Published in Inflammation and Regeneration
The liver has a high regenerative ability and can induce spontaneous regression of fibrosis when early liver damage occurs; however, these abilities are lost when chronic liver damage results in decompensated cirrhosis. Cell therapies, such as mesenchymal stem cell (MSC) and macrophage therapies, have attracted attention as potential strategies for...
Similarities of developmental gene expression changes in the brain between human and experimental animals: rhesus monkey...
Published in Molecular Brain
Aim Experimental animals, such as non-human primates (NHPs), mice, Zebrafish, and Drosophila, are frequently employed as models to gain insights into human physiology and pathology. In developmental neuroscience and related research fields, information about the similarities of developmental gene expression patterns between animal models and humans...
Sex differences and similarities in the neuroimmune response to central administration of poly I:C
Published in Journal of Neuroinflammation
Background The neuroimmune system is required for normal neural processes, including modulation of cognition, emotion, and adaptive behaviors. Aberrant neuroimmune activation is associated with dysregulation of memory and emotion, though the precise mechanisms at play are complex and highly context dependent. Sex differences in neuroimmune activati...
Stabilizing breathing pattern using local mechanical vibrations: comparison of deterministic and stochastic stimulations...
...Published in Biomedical Engineering Letters
Mechanical stimulation has been shown to reduce apnea of prematurity (AOP), a major concern in preterm infants. Previous work suggested that the underlying mechanism is stochastic resonance, amplification of a subthreshold signal by stochastic stimulation. We hypothesized that the mechanism behind the reduction of apnea length may not be a solely s...
Cognitive and hippocampal synaptic profiles in monosodium glutamate-induced obese mice.
Published in Neuroscience research
Obesity is a growing worldwide public health issue and is associated with a range of comorbidities, including cognitive deficits. The present study investigated synaptic changes in the hippocampus during the development of obesity. The treatment of newborn mice with monosodium-L-glutamate (MSG, 2 mg/g) induced obesity and recognition memory deficit...
Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice
Published in Nature Communications
The in vivo identification of proteins secreted from a specific cell type or tissue remains challenging. Here, the authors develop a proximity labeling-based method to selectively label secreted proteins and combine it with proteomics to identify liver secretory proteins in mouse plasma.
Altered synaptic glutamate homeostasis contributes to cognitive decline in young APP/PSEN1 mice
Published in Neurobiology of disease
Non-convulsive epileptiform activity is a common and under-studied comorbidity of Alzheimer’s disease that may significantly contribute to onset of clinical symptoms independently of other neuropathological features such as β-amyloid deposition. We used repeated treatment with low dose kainic acid (KA) to trigger subthreshold epileptiform activity ...
Mesenchymal stromal cells-based therapy in a murine model of elastase-induced emphysema: Simvastatin as a potential adju...
Published in Pulmonary pharmacology & therapeutics
Chronic Obstructive Pulmonary Disease - COPD is characterized by the destruction of alveolar walls associated to a chronic inflammatory response of the airways. There is no clinical therapy for COPD. In this context, cell-based therapies represent a promising therapeutic approach for chronic lung disease. The goal of this work was to evaluate the e...
Touchless Control of Picture Archiving and Communication System in Operating Room Environment: A Comparative Study of In...
Published in Clinics in Orthopedic Surgery
Background The advancement of computer information technology would maximize its potential in operating rooms with touchless input devices. A picture archiving and communication system (PACS) was compared with a touchless input device (LMC-GW), relaying to another person to control a mouse through verbal guidance, and directly controlling a mouse. ...
