Bucher, Simon Begriche, Karima Catheline, Daniel Trak-Smayra, Viviane Tiaho, François Coulouarn, Cédric Pinon, Grégory Lagadic-Gossmann, Dominique Rioux, Vincent Fromenty, Bernard
...
Published in
European journal of nutrition
Several clinical studies suggested that light-to-moderate alcohol intake could alleviate nonalcoholic fatty liver disease (NAFLD), but the underlying mechanism is still poorly understood. Mice fed a high-fat diet (HFD) were submitted or not to moderate ethanol intake for 3 months (ca. 10 g/kg/day) via drinking water. Biochemical, analytical and tra...
Teepker, M. Peters, M. Vedder, H. Schepelmann, K. Lautenbacher, S.
Published in
Neuropsychobiology
Background: The results of studies examining the response to experimental pain during the menstrual cycle are conflicting because of differences in the definitions of the menstrual period, outcome measures and types of experimental pain stimulation. So far, there have been only a few studies correlating experimental pain with the levels of gonadal ...
van de Wouw, Marcel Walsh, Aaron M. Crispie, Fiona van Leuven, Lucas Lyte, Joshua M. Boehme, Marcus Clarke, Gerard Dinan, Timothy G. Cotter, Paul D. Cryan, John F.
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Published in
Microbiome
BackgroundMounting evidence suggests a role for the gut microbiota in modulating brain physiology and behaviour, through bi-directional communication, along the gut-brain axis. As such, the gut microbiota represents a potential therapeutic target for influencing centrally mediated events and host behaviour. It is thus notable that the fermented mil...
Kischel, Anthony Audouard, Christophe Fawal, Mohamad-Ali Davy, Alice
Published in
BMC Developmental Biology
BackgroundDuring mammalian cerebral cortex development, different types of projection neurons are produced in a precise temporal order and in stereotypical numbers. The mechanisms regulating timely generation of neocortex projection neurons and ensuring production in sufficient numbers of each neuronal identity are only partially understood.Results...
Kikuchi, Motoshi Takase, Kenkichi Hayakawa, Morisada Hayakawa, Hiroko Tominaga, Shin-ichi Ohmori, Tsukasa
Published in
Molecular Brain
Psychoneuroimmunological studies have clearly demonstrated that both cellular and humoral immunity are related to major depression. Soluble ST2 is regarded as a key molecule regulating immune system as well as cell proliferation. Indeed, soluble ST2 is reported to reduce IL-33-induced IL-6 and TNF-α production in macrophages and IL-33-induced IL-5 ...
Lawal, Tokunbor A. Wires, Emily S. Terry, Nancy L. Dowling, James J. Todd, Joshua J.
Published in
Orphanet Journal of Rare Diseases
BackgroundPathogenic variations in the gene encoding the skeletal muscle ryanodine receptor (RyR1) are associated with malignant hyperthermia (MH) susceptibility, a life-threatening hypermetabolic condition and RYR1-related myopathies (RYR1-RM), a spectrum of rare neuromuscular disorders. In RYR1-RM, intracellular calcium dysregulation, post-transl...
Benian, Guy M Choo, Hyojung J
Published in
eLife
An multi-species approach can be used to identify small molecules with properties that might prove useful for the treatment of some neuromuscular diseases.
Um, Da-Eun Shin, Hyejin Park, Dayoung Ahn, Jeong Min Kim, Jayeon Song, Haengseok Lim, Hyunjung Jade
Published in
Reproductive Biology and Endocrinology
BackgroundWe had previously demonstrated that vitrification reduces the levels of certain phospholipid classes, and that oocytes from aged mice show a similar lipidome alteration, even without vitrification. In the current investigation, we examined if vitrification-warming of mouse oocytes from young and aged mice causes any changes in molecular a...
Ueno, Hiroshi Suemitsu, Shunsuke Murakami, Shinji Kitamura, Naoya Wani, Kenta Takahashi, Yu Matsumoto, Yosuke Okamoto, Motoi Ishihara, Takeshi
Published in
BMC Neuroscience
BackgroundEmpathy refers to the ability to recognise and share emotions with others. Several research groups have recognised observational fear in mice as a useful behavioural model for assessing their ability to empathise. However, in these observation systems, it remains unclear whether the observer mouse truly recognises the movements of, and em...
Keener, David G. Cheung, Amy Futai, Kensuke
BACKGROUND: Exogenous gene introduction by transfection is one of the most important approaches for understanding the function of specific genes at the cellular level. Electroporation has a long-standing history as a versatile gene delivery technique in vitro and in vivo. However, it has been underutilized in vitro because of technical difficulty a...
