Petroff, Avi Pena Diaz, Ana Armstrong, James J Gonga-Cavé, Brianna C Hutnik, Cindy O'Gorman, David B
Published in
Ocular immunology and inflammation
Inflammation is associated with, and may be causal of, a variety of ophthalmic pathologies. These pathologies are currently difficult to model in vitro because they involve complex interactions between the innate immune system, stromal cells, and other cells that normally maintain ocular tissue homeostasis. Using transscleral drainage channel fibro...
Salomonsson, M Cardenas, E I Dahlin, J S Kalm-Stephens, P Janson, C Malinovschi, A Alving, K Hallgren, J
Published in
Journal of investigational allergology & clinical immunology
Ji, Lili Guo, Wei
Published in
Pharmacological research
Single-cell RNA sequencing (scRNA-seq) technology is a powerful tool for characterizing individual cells and elucidating biological mechanisms at the cellular level. Using this technology, this study focuses on the mechanism of C1QB and NKG7 in pancreatic islet immune microenvironment in type 1 diabetes mellitus (T1DM). T1DM-related scRNA-seq data ...
Godoy-Tena, Gerard Barmada, Anis Morante-Palacios, Octavio de la Calle-Fabregat, Carlos Martins-Ferreira, Ricardo Ferreté-Bonastre, Anna G Ciudad, Laura Ruiz-Sanmartín, Adolfo Martínez-Gallo, Mónica Ferrer, Ricard
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Background
COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myeloid compartment, especially monocytes. However, little is known about the epigenetic alterations that occur in these cells during hy...
Cui, Hao Lan, Zhou Zou, Ke-Long Zhao, Yu-Yue Yu, Guang-Tao
Published in
Cancer immunology, immunotherapy : CII
Myeloid-derived suppressor cells (MDSCs) are one of the tumor-infiltrating immune cell population, which play a powerful role in inhibiting anti-tumor immune response. Our previous studies have shown that STAT3 blockade can decrease the number of MDSCs in tumor microenvironment. However, it is unclear for the molecular mechanism of down-regulation ...
Richoz, Nathan Tuong, Zewen K Loudon, Kevin W Patiño-Martínez, Eduardo Ferdinand, John R Portet, Anaïs Bashant, Kathleen R Thevenon, Emeline Rucci, Francesca Hoyler, Thomas
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Lupus nephritis is a serious complication of systemic lupus erythematosus, mediated by IgG immune complex (IC) deposition in kidneys, with limited treatment options. Kidney macrophages are critical tissue sentinels that express IgG-binding Fcγ receptors (FcγRs), with previous studies identifying prenatally seeded resident macrophages as major IC re...
Selleri, Valentina Mattioli, Marco Lo Tartaro, Domenico Paolini, Annamaria Zanini, Giada De Gaetano, Anna D'Alisera, Roberta Roli, Laura Melegari, Alessandra Maietta, Pasqualino
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Published in
BMC sports science, medicine & rehabilitation
Whole-body cryotherapy (WBC) consists of short exposure (up to 2-3 min) to dry air at cryogenic temperatures (up to -190 °C) and has recently been applied for muscle recovery after injury to reduce the inflammation process. We aimed to determine the impact of cryotherapy on immunological, hormonal, and metabolic responses in non-professional soccer...
Trovato, FM Zia, R Artru, F Mujib, S Jerome, E Cavazza, A Coen, M Wilson, I Holmes, E Morgan, P
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BACKGROUND AND AIMS: Acute liver failure (ALF) is a life-threatening disease characterised by high-grade inflammation and immunoparesis with a high incidence of death from sepsis. Here, we aimed to describe the metabolic dysregulation in ALF and determine whether systemic immune responses are modulated via the lysophosphatidylcholine(LPC)-autotaxin...
Puukila, Stephanie Lawrence, Mark D De Pasquale, Carmine G Bersten, Andrew D Bihari, Shailesh McEvoy-May, James Nemec-Bakk, Ashley Dixon, Dani-Louise
Published in
Cytokine
Dyspnea, the cardinal manifestation of chronic heart failure (CHF), may reflect both pulmonary oedema and pulmonary remodeling resulting in tissue stiffening. Emerging evidence suggests that predominance of distinct phenotypes of alveolar and recruited macrophages, designated M1 and M2, may regulate the course of inflammatory tissue repair and remo...
Schrijver, Irene T Théroude, Charlotte Antonakos, Nikolaos Regina, Jean Le Roy, Didier Bart, Pierre-Alexandre Chiche, Jean-Daniel Perreau, Matthieu Pantaleo, Giuseppe Calandra, Thierry
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Published in
European journal of immunology
We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID-19 induces a rapid, transient upregulation of myeloid-derived suppressor cells (MDSCs) accompanied by a rapid, sustained (up to 3 months) hyporesponsiveness of dendritic cells and monocytes. B...
