Sabbah, Nadia Jaisson, Stéphane Garnotel, Roselyne Anglés-Cano, Eduardo Gillery, Philippe
Published in
Lipids in Health and Disease
BackgroundAtherosclerosis is an inflammatory process involving activation of monocytes recruited by various chemoattractant factors, among which lipoprotein(a) and its specific apolipoprotein apo(a). Lp(a) contains a specific apolipoprotein apo(a) which size is determined by a variable number of repeats of a specific structural domain, the kringle ...
Yang, Hongtian Graham, Leah C. Reagan, Alaina M. Grabowska, Weronika A. Schott, William H. Howell, Gareth R.
Published in
Journal of Neuroinflammation
BackgroundEnvironmental factors are critical in the development of age-related cognitive decline and dementia. A western diet (WD) can cause nutrient deficiency and inflammation that could impact cognition directly. It is increasingly recognized that innate immune responses by brain myeloid cells, such as resident microglia, and infiltrating periph...
Hasvik, Eivind Schjølberg, Tiril Jacobsen, Daniel Pitz Haugen, Anne Julsrud Grøvle, Lars Schistad, Elina Iordanova Gjerstad, Johannes
Published in
Arthritis Research & Therapy
BackgroundPrevious studies suggest that regulatory microRNAs (miRs) may modulate neuro-inflammatory processes. The purpose of the present study was to examine the role of miR-17 following intervertebral disc herniation.MethodsIn a cohort of 97 patients with leg pain and disc herniation verified on MRI, we investigated the association between circul...
Li, Ming Xie, Zhongyu Cai, Zhaopeng Su, Fang Zheng, Guan Li, Jinteng Wang, Shan Cen, Shuizhong Liu, Wenjie Tang, Su’an
...
Published in
Stem Cell Research & Therapy
BackgroundThe goals of this study were to explore the expression profiles and functional networks of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in mesenchymal stromal cells (MSCs) involved in regulating the function of monocytes and to clarify the mechanisms by which MSCs exert immunoregulatory effects on monocytes.MethodsMSCs and CD...
Schwarz, Frank Langer, Maike Hagena, Tina Hartig, Brigitte Sader, Robert Becker, Jürgen
Published in
International Journal of Implant Dentistry
BackgroundTo assess the effects of differently sized titanium (Ti) and zirconia (Zr) particles on (1) the metabolic activity of osteosarcoma-derived osteoblasts (SaOs-2) and human gingival fibroblasts (HGF) and (2) the cytokine expression of monocytes (THP-1)MethodsTi (60–80 nm and 100 nm) and Zr (2 μm and 75 μm) particles were incubated with SaOs-...
Chen, Mei Obasanmi, Gideon Armstrong, David Lavery, Nuala-Jane Kissenpfennig, Adrien Lois, Noemi Xu, Heping
Published in
Journal of Neuroinflammation
BackgroundLeukostasis is a key patho-physiological event responsible for capillary occlusion in diabetic retinopathy. Circulating monocytes are the main cell type entrapped in retinal vessels in diabetes. In this study, we investigated the role of the signal transducer and activator of transcription 3 (STAT3) pathway in diabetes-induced immune cell...
Peng, Anping Lu, Xinyi Huang, Jun He, Min Xu, Jianhua Huang, Hui Chen, Qubo
Published in
Arthritis Research & Therapy
BackgroundTriggering receptor expressed on myeloid cells-1 (TREM-1) is inducible on monocyte/macrophages and neutrophils and amplifies the inflammatory response. The aim of this study was to determine whether rheumatoid arthritis synovial fibroblasts (RASF) promote the expression of TREM-1 in monocytes and its potential regulatory mechanism.Methods...
Will, Thorsten Helms, Volkhard
Published in
BMC Bioinformatics
BackgroundAlthough a considerable number of proteins operate as multiprotein complexes and not on their own, organism-wide studies so far are only able to quantify individual proteins or protein-coding genes in a condition-specific manner for a sizeable number of samples, but not their assemblies. Consequently, there exist large amounts of transcri...
Busch, Svenja Talamini, Marina Brenner, Steffen Abdulazim, Amr Hänggi, Daniel Neumaier, Michael Seiz-Rosenhagen, Marcel Fuchs, Tina
Published in
Clinical and Translational Medicine
BackgroundGlioblastoma is the most common and malignant brain tumor in adults. Glioblastoma is usually fatal 12–15 months after diagnosis and the current possibilities in therapy are mostly only palliative. Therefore, new forms of diagnosis and therapy are urgently needed. Since tumor-associated macrophages are key players in tumor progression and ...
Beez, Christien M. Haag, Marion Klein, Oliver Van Linthout, Sophie Sittinger, Michael Seifert, Martina
Published in
Journal of Nanobiotechnology
BackgroundNano-sized vesicles, so called extracellular vesicles (EVs), from regenerative cardiac cells represent a promising new therapeutic approach to treat cardiovascular diseases. However, it is not yet sufficiently understood how cardiac-derived EVs facilitate their protective effects. Therefore, we investigated the immune modulating capabilit...
