Dedon, Liv R. Ozcan, Ezgi Rani, Asha Sela, David A.
Human milk oligosaccharides (HMOs) enrich beneficial bifidobacteria in the infant gut microbiome which produce molecules that impact development and physiology. 2'fucosyllactose (2'FL) is a highly abundant fucosylated HMO which is utilized by Bifidobacterium longum subsp. infantis, despite limited scientific understanding of the underlying mechanis...
Lauterbach, Mario A. Latz, Eicke Christ, Anette
Changes in modern dietary habits such as consumption of Western-type diets affect physiology on several levels, including metabolism and inflammation. It is currently unclear whether changes in systemic metabolism due to dietary interventions are long-lasting and affect acute inflammatory processes. Here, we investigated how high-fat diet (HFD) fee...
Myers, James R. Wallace, Lyle T. Mafi Moghaddam, Samira Kleintop, Adrienne E. Echeverria, Dimas Thompson, Henry J. Brick, Mark A. Lee, Rian McClean, Phillip E.
Snap beans are a significant source of micronutrients in the human diet. Among the micronutrients present in snap beans are phenolic compounds with known beneficial effects on human health, potentially via their metabolism by the gut-associated microbiome. The genetic pathways leading to the production of phenolics in snap bean pods remain uncertai...
Hernandez, Gabriella Veronica Smith, Victoria Alice Coffin, Morgan Columbus, Daniel Burd, Matthew Sprayberry, Kimberly Edwards, Mark Peterson, Daniel Bennett, Darin Fanter, Robert
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The prevalence of non-alcoholic fatty liver disease (NAFLD) in children has increased over the past decades, creating a need for animal models that recapitulate the features of the pediatric disease. Iberian pigs have a leptin-resistant phenotype characterized by hyperleptinemia, hyperphagia, and extreme adipogenesis. We hypothesized that neonatal ...
Suk, Sujin Kwon, Gyoo Taik Lee, Eunjung Jang, Woo Jung Yang, Hee Kim, Jong Hun Thimmegowda, N. R. Chung, Min-Yu Kwon, Jung Yeon Yang, Seunghee
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SCOPE: Ginger exerts protective effects on obesity and its complications. Our objectives here are to identify bioactive compounds that inhibit adipogenesis and lipid accumulation in vitro, elucidate the anti-obesity effect of gingerenone A (GA) in diet-induced obesity (DIO), and investigate whether GA affects adipose tissue inflammation (ATI). METH...
Watson, Emma
Maintaining cellular homeostasis is a complex task, which involves monitoring energy states and essential nutrients, regulating metabolic fluxes to accommodate energy and biomass needs, and preventing buildup of potentially toxic metabolic intermediates and byproducts. Measures aimed at maintaining a healthy cellular economy inherently depend on th...
Fuller, Kristina
Pyruvate kinases serve an important role in regulating glycolysis pathways. Different pyruvate kinase isozymes can dictate which of several different products will be formed during the final step of glycolysis. Being able to reliably copy active pyruvate kinases (PK) would allow study of the different isozymes, with the goal of eventually creating ...
Yilmaz, L. Safak Walhout, Albertha J. M.
Micronutrients are required in small proportions in a diet to carry out key metabolic roles for biomass and energy production. Humans receive micronutrients either directly from their diet or from gut microbiota that metabolize other nutrients. The nematode Caenorhabditis elegans and its bacterial diet provide a relatively simple and genetically tr...
Watson, Emma Walhout, Albertha J. M.
Diet greatly impacts metabolism in health and disease. In response to the presence or absence of specific nutrients, metabolic gene regulatory networks sense the metabolic state of the cell and regulate metabolic flux accordingly, for instance by the transcriptional control of metabolic enzymes. Here, we discuss recent insights regarding metazoan m...
Watson, Emma MacNeil, Lesley T. Ritter, Ashlyn D. Yilmaz, L. Safak Rosebrock, Adam P. Caudy, Amy A. Walhout, Albertha J. M.
Diet greatly influences gene expression and physiology. In mammals, elucidating the effects and mechanisms of individual nutrients is challenging due to the complexity of both the animal and its diet. Here, we used an interspecies systems biology approach with Caenorhabditis elegans and two of its bacterial diets, Escherichia coli and Comamonas aqu...