Silveira, Sandra Cunha Buhagiar-Labarchède, Géraldine Onclercq-Delic, Rosine Gemble, Simon Bou Samra, Elias Mameri, Hamza Duchambon, Patricia Machon, Christelle Guitton, Jérôme Amor-Guéret, Mounira
...
Published in
Scientific Reports
Cytidine deaminase (CDA) deficiency causes pyrimidine pool disequilibrium. We previously reported that the excess cellular dC and dCTP resulting from CDA deficiency jeopardizes genome stability, decreasing basal poly(ADP-ribose) polymerase 1 (PARP-1) activity and increasing ultrafine anaphase bridge (UFB) formation. Here, we investigated the mechan...
Makshakova, Olga Breton, Christelle Perez, Serge
Published in
Scientific Reports
Chloroplast membranes have a high content of the uncharged galactolipids monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG). These galactolipids are essential for the biogenesis of plastids and functioning of the photosynthetic machinery. A monotopic glycosyltransferase, monogalactosyldiacylglycerol synthase synthesizes the b...
Trzaska, Carole Amand, Séverine Bailly, Christine Leroy, Catherine Marchand, Virginie Duvernois-Berthet, Evelyne Saliou, Jean-Michel Benhabiles, Hana Werkmeister, Elisabeth Chassat, Thierry
...
Published in
Nature Communications
Nonsense mutations can be corrected by several molecules that activate readthrough of premature termination codon. Here, the authors report that 2,6-diaminopurine efficiently corrects UGA nonsense mutations with no significant toxicity.
Djemiel, Christophe Plassard, Damien Terrat, Sébastien Crouzet, Olivier Sauze, Joana Mondy, Samuel Nowak, Virginie Wingate, Lisa Ogée, Jérôme Maron, Pierre-Alain
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Published in
Scientific Reports
Studying the ecology of photosynthetic microeukaryotes and prokaryotic cyanobacterial communities requires molecular tools to complement morphological observations. These tools rely on specific genetic markers and require the development of specialised databases to achieve taxonomic assignment. We set up a reference database, called µgreen-db, for ...
Vivien, Régis Apothéloz-Perret-Gentil, Laure Pawlowski, Jan Werner, Inge Lafont, Michel Ferrari, Benoit J. D.
Published in
Scientific Reports
Aquatic oligochaete communities are valuable indicators of the biological quality of sediments in streams and lakes, but identification of specimens to the species level based on morphological features requires solid expertise in taxonomy and is possible only for a fraction of specimens present in a sample. The identification of aquatic oligochaete...
Narayanan, Gitanjali A. Nellore, Abhinav Tran, Jessica Worley, Aneta H. Meermeier, Erin W. Karamooz, Elham Huber, Megan E. Kurapova, Regina Tafesse, Fikadu G. Harriff, Melanie J.
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Published in
Scientific Reports
Mucosal Associated Invariant T (MAIT) cells can sense intracellular infection by a broad array of pathogens. These cells are activated upon encountering microbial antigen(s) displayed by MR1 on the surface of an infected cell. Human MR1 undergoes alternative splicing. The full-length isoform, MR1A, can activate MAIT cells, while the function of the...
Jun, Jong Hwa Son, Myeong-Jin Lee, Hyun-Gyo Shim, Kyu Young Baek, Won-Ki Kim, Jae-Young Joo, Choun-Ki
Published in
Scientific Reports
Uncontrolled retinal pigment epithelial (RPE) cell proliferation/migration contribute to the pathological tractional membrane development in proliferative vitreoretinopathy. Recent studies reported that microRNA (miR)-124 controls various cellular functions via the direct targeting of small Ras homolog family member G (RHOG). Therefore, we investig...
Yang, Chengshuai Li, Chaojing Wei, Wei Wei, Yongjun Liu, Qunfang Zhao, Guoping Yue, Jianmin Yan, Xing Wang, Pingping Zhou, Zhihua
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Published in
Scientific Reports
More than 150 ginsenosides have been isolated and identified from Panax plants. Ginsenosides with different glycosylation degrees have demonstrated different chemical properties and bioactivity. In this study, we systematically cloned and characterized 46 UGT94 family UDP-glycosyltransferases (UGT94s) from a mixed Panax ginseng/callus cDNA sample w...
Piyush, Ravikant Rajarshi, Keshav Chatterjee, Aroni Khan, Rajni Ray, Shashikant
Published in
Heliyon
Microbiology; Biotechnology; Molecular biology; Epidemiology; Virology; Regenerative medicine; Covid-19; SARS-CoV-2; Nucleic acid based therapy; siRNA; Ribozymes; DNAzymes; Aptamers; Antisense; Oligonucleotide
McGovern, Emily McGee, Mark Byrne, Colin J. Kenny, David A. Kelly, Alan K. Waters, Sinéad M.
Published in
Scientific Reports
The relationship between rumen microbiota and host feed efficiency phenotype, for genetically divergent beef cattle breeds is unclear. This is further exacerbated when different growth stages, chemically diverse diets and production systems are considered. Residual feed intake (RFI), a measure of feed efficiency, was calculated for individually fed...
