Walczak, Konrad Stawski, Robert Perdas, Ewelina Brzezinska, Olga Kosielski, Piotr Galczynski, Szymon Budlewski, Tomasz Padula, Gianluca Nowak, Dariusz
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Scientific Reports
It is believed that neutrophils extracellular traps (NETs) formation is responsible for the increase in cf DNA after exercise. Since T1DM is accompanied by enhanced NETs generation, we compared exercise-induced increase in cf DNA in 14 men with T1DM and 11 healthy controls and analyzed its association with exercise load. Subjects performed a treadm...
Wolski, Hubert Kurzawińska, Grażyna Ożarowski, Marcin Mrozikiewicz, Aleksandra E. Drews, Krzysztof Karpiński, Tomasz M. Bogacz, Anna Seremak-Mrozikiewicz, Agnieszka
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Scientific Reports
A few years ago it was shown that disturbed metabolism of the vitamin D/receptor (VD/VDR) complex may be important in the etiology of spontaneous abortion, as well as in the etiology of recurrent miscarriages (RM). The goal of this study was to investigate the association between four maternal VDR polymorphisms as well as haplotypes settings and RM...
Kitajima, Shojiro Sun, Wendi Lee, Kian Leong Ho, Jolene Caifeng Oyadomari, Seiichi Okamoto, Takashi Masai, Hisao Poellinger, Lorenz Kato, Hiroyuki
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Scientific Reports
UTX/KDM6A encodes a major histone H3 lysine 27 (H3K27) demethylase, and is frequently mutated in various types of human cancers. Although UTX appears to play a crucial role in oncogenesis, the mechanisms involved are still largely unknown. Here we show that a specific pharmacological inhibitor of H3K27 demethylases, GSK-J4, induces the expression o...
Golovinas, Edvardas Rutkauskas, Danielis Manakova, Elena Jankunec, Marija Silanskas, Arunas Sasnauskas, Giedrius Zaremba, Mindaugas
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Scientific Reports
Argonaute (Ago) proteins are found in all three domains of life. The best-characterized group is eukaryotic Argonautes (eAgos), which are the core of RNA interference. The best understood prokaryotic Ago (pAgo) proteins are full-length pAgos. They are composed of four major structural/functional domains (N, PAZ, MID, and PIWI) and thereby closely r...
Ranieri, Marianna Di Mise, Annarita Centrone, Mariangela D’Agostino, Mariagrazia Tingskov, Stine Julie Venneri, Maria Pellegrino, Tommaso Difonzo, Graziana Caponio, Francesco Norregaard, Rikke
...
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Scientific Reports
Vasopressin (AVP) increases water permeability in the renal collecting duct through the regulation of aquaporin-2 (AQP2) trafficking. Several disorders, including hypertension and inappropriate antidiuretic hormone secretion (SIADH), are associated with abnormalities in water homeostasis. It has been shown that certain phytocompounds are beneficial...
Wang, Xia-Fei Chen, Zhe Wang, Xu-Bo Xu, Jin Chen, Peng Ye, Hui
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Scientific Reports
The neuropeptide natalisin (NTL) has been determined to play essential roles in reproduction in two Diptera and one Coleoptera species. Whether NTL has similar or even different functions in Lepidoptera remains to be determined. Here, we cloned the NTL transcript in the common cutworm moth Spodoptera litura . This transcript encodes a 438-amino aci...
Wigner, Paulina Zielinski, Krzysztof Labieniec-Watala, Magdalena Marczak, Agnieszka Szwed, Marzena
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Scientific Reports
Doxorubicin (DOX) is considered one of the most powerful chemotherapeutic agents but its clinical use has several limitations, including cardiomyopathy and cellular resistance to the drug. By using transferrin (Tf) as a drug carrier, however, the adverse effects of doxorubicin as well as drug resistance can be reduced. The main objective of this st...
Le, Quynh Giang Ishiwata-Kimata, Yuki Phuong, Thi Huong Fukunaka, Shigeto Kohno, Kenji Kimata, Yukio
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Scientific Reports
Upon endoplasmic-reticulum (ER) stress, the ER-located transmembrane protein, Ire1, is autophosphorylated and acts as an endoribonuclease to trigger the unfolded protein response (UPR). Previous biochemical studies have shown that Ire1 exhibits strong endoribonuclease activity when its cytosolic kinase region captures ADP. Here, we asked how this e...
Paulsen, Isabella W. Bzorek, Michael Olsen, Jesper Grum-Schwensen, Birgitte Troelsen, Jesper T. Pedersen, Ole B.
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Scientific Reports
Identification of target tissue microRNAs (miR) using in situ hybridization (ISH), with digoxigenin-labeled locked nucleic acid (LNA) probes, is influenced by preanalytic parameters. To determine the best retrieval method for common microRNAs, a multiblock composed of paraffin-embedded tonsil, cervix, placenta, and hyperplastic prostate tissue were...
Poveda, Andres Oaknin, Ana Romero, Ignacio Guerrero-Zotano, Angel Fariñas-Madrid, Lorena Rodriguez-Freixinos, Victor Mallol, Pedro Lopez-Reig, Raquel Lopez-Guerrero, Jose Antonio
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Scientific Reports
The poly (ADP-Ribose) polymerase (PARP) inhibitor olaparib has shown antitumor activity in patients with ovarian or breast cancer with or without BRCA1/2 mutations. Lurbinectedin is an ecteinascidin that generates DNA double-strand breaks. We hypothesized that the combination of olaparib and lurbinectedin maximizes the DNA damage increasing the eff...