Alzeibak, Razan Mishchenko, Tatiana A. Shilyagina, Natalia Y. Balalaeva, Irina V. Vedunova, Maria V. Krysko, Dmitri V.
Published in
Journal for Immunotherapy of Cancer
The past decade has witnessed major breakthroughs in cancer immunotherapy. This development has been largely motivated by cancer cell evasion of immunological control and consequent tumor resistance to conventional therapies. Immunogenic cell death (ICD) is considered one of the most promising ways to achieve total tumor cell elimination. It activa...
Van de Velde, Frederique Deventer, Koen Van Gansbeke, Wim Van Eenoo, Peter Van Renterghem, Pieter Fiers, Tom Reyns, Tim Kaufman, Jean Van Nieuwenhove, Yves Lapauw, Bruno
...
Zhong, Zifu McCafferty, Séan Opsomer, Lisa Wang, Haixiu Huysmans, Hanne De Temmerman, Joyca Lienenklaus, Stefan Portela Catani, João Paulo Combes, Francis Sanders, Niek
...
Jian, Yanlin Forbes, He Eun Hulpia, Fabian Risseeuw, Martijn Caljon, Guy Munier-Lehmann, Hélène Boshoff, Helena I. M. Van Calenbergh, Serge
Swapping the substituents in positions 2 and 4 of the previously synthesized but yet undisclosed 5-cyano-4-(methylthio)-2-arylpyrimidin-6-ones 4, ring closure, and further optimization led to the identification of the potent antitubercular 2-thio-substituted quinazolinone 26. Structure-activity relationship (SAR) studies indicated a crucial role fo...
Zhong, Zifu Combes, Francis Sanders, Niek
Edris Mohamed, Ahmed Vanoverschelde, Anna Bushaj, Pranvera Van Nieuwerburgh, Filip Lahousse, Lies
Over the past decade, pharmacogenetics (PGx) became an essential tool for personalized medicine although its clinical implementation is still limited. We aimed to assess the current level of knowledge, applications, and expectations of Flemish pharmacists and physicians towards PGx and determine the factors that influence healthcare professionals' ...
Van Hoecke, Lien Roose, Kenny Ballegeer, Marlies Zhong, Zifu Sanders, Niek N De Koker, Stefaan Saelens, Xavier Van Lint, Sandra
Published in
Molecular therapy. Nucleic acids
mRNA-lipoplex vaccines are currently being explored in phase II clinical trials for the treatment of patients with advanced solid tumors. Mechanistically, these mRNA-lipoplex vaccines are characterized by the induction of type I interferon (IFN) centered innate responses. Earlier studies have identified type I IFNs as major regulators of the T cell...
Sirakaya, Aysegül De Brucker, Klaas Vanagt, Thomas
In this paper we conduct a multi-criteria analysis (MCA) from a multiple stakeholder point of view for the design of access and benefit sharing (ABS) agreements concerning genetic resources, in particular regarding the access component of such agreements. We start by analyzing the objectives defined by international law (viz. the Convention on Biod...
Bellini, Valeria Swale, Christopher Brenier-Pinchart, Marie-Pierre Pezier, Tiffany Georgeault, Sonia Laurent, Fabrice Hakimi, Mohamed-Ali Bougdour, Alexandre
Boron-containing compounds represent a promising class of molecules with proven efficacy against a wide range of pathogens, including apicomplexan parasites. Following lead optimization, the benzoxaborole AN13762 was identified as a preclinical candidate against the human malaria parasite, yet the molecular target remained uncertain. Here, we uncov...
Bulterijs, Sven Braeckman, Bart P.
Published in
Pharmaceuticals
Population aging is one of the largest challenges of the 21st century. As more people live to advanced ages, the prevalence of age-related diseases and disabilities will increase placing an ever larger burden on our healthcare system. A potential solution to this conundrum is to develop treatments that prevent, delay or reduce the severity of age-r...