Beerts, Charlotte Brondeel, Carlien Pauwelyn, Glenn Depuydt, Eva Tack, Liesa Duchateau, Luc Xu, Yangfeng Saunders, Jimmy H. Peremans, Kathelijne Spaas, Jan H.
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Published in
Stem Cell Research & Therapy
BackgroundMesenchymal stem cell treatments in dogs have been investigated as a potential innovative alternative to current conventional therapies for a variety of conditions. So far, the precise mode of action of the MSCs has yet to be determined. The aim of this study was to gain more insights into the pharmacokinetics of MSCs by evaluating their ...
Corpas, Manuel Beck, Stephan Glusman, Gustavo Shabani, Mahsa
Published in
Frontiers in Genetics
Gillentine, Madelyn A. Wang, Tianyun Hoekzema, Kendra Rosenfeld, Jill Liu, Pengfei Guo, Hui Kim, Chang N. De Vries, Bert B. A. Vissers, Lisenka E. L. M. Nordenskjold, Magnus
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Published in
Genome Medicine
BackgroundWith the increasing number of genomic sequencing studies, hundreds of genes have been implicated in neurodevelopmental disorders (NDDs). The rate of gene discovery far outpaces our understanding of genotype–phenotype correlations, with clinical characterization remaining a bottleneck for understanding NDDs. Most disease-associated Mendeli...
Van Hoecke, Lien Verbeke, Rein Dewitte, Heleen Lentacker, Ine Vermaelen, Karim Breckpot, Karine Van Lint, Sandra
Published in
Molecular Cancer
mRNA therapeutics have become the focus of molecular medicine research. Various mRNA applications have reached major milestones at high speed in the immuno-oncology field. This can be attributed to the knowledge that mRNA is one of nature’s core building blocks carrying important information and can be considered as a powerful vector for delivery o...
Alzeibak, Razan Mishchenko, Tatiana A. Shilyagina, Natalia Y. Balalaeva, Irina V. Vedunova, Maria V. Krysko, Dmitri V.
Published in
Journal for Immunotherapy of Cancer
The past decade has witnessed major breakthroughs in cancer immunotherapy. This development has been largely motivated by cancer cell evasion of immunological control and consequent tumor resistance to conventional therapies. Immunogenic cell death (ICD) is considered one of the most promising ways to achieve total tumor cell elimination. It activa...
Lorenzi, Lucia Chiu, Hua-Sheng Avila Cobos, Francisco Gross, Stephen Volders, Pieter-Jan Cannoodt, Robrecht Nuytens, Justine Vanderheyden, Katrien Anckaert, Jasper Lefever, Steve
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Van de Velde, Frederique Deventer, Koen Van Gansbeke, Wim Van Eenoo, Peter Van Renterghem, Pieter Fiers, Tom Reyns, Tim Kaufman, Jean Van Nieuwenhove, Yves Lapauw, Bruno
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Objective: Men with obesity often have low total and, with increasing adiposity, also low free testosterone (T) levels, which can partially restore during weight loss. Although this is partly explained by lower sex hormone binding globulin (SHBG) production and hypothalamic-pituitary downregulation, it is still not unravelled whether changes in and...
Zhong, Zifu Mc Cafferty, Séan Opsomer, Lisa Wang, Haixiu Huysmans, Hanne De Temmerman, Joyca Lienenklaus, Stefan Portela Catani, João Combes, Francis Sanders, Niek
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Synthetic mRNAs are an appealing platform with multiple biomedical applications ranging from protein replacement therapy to vaccination. In comparison with conventional mRNA, synthetic self-amplifying mRNAs (sa-mRNAs) are gaining interest because of their higher and longer-lasting expression. However, sa-mRNAs also elicit an innate immune response,...
Jian, Yanlin Forbes, He Eun Hulpia, Fabian Risseeuw, Martijn Caljon, Guy Munier-Lehmann, Hélène Boshoff, Helena I. M. Van Calenbergh, Serge
Swapping the substituents in positions 2 and 4 of the previously synthesized but yet undisclosed 5-cyano-4-(methylthio)-2-arylpyrimidin-6-ones 4, ring closure, and further optimization led to the identification of the potent antitubercular 2-thio-substituted quinazolinone 26. Structure-activity relationship (SAR) studies indicated a crucial role fo...
Zhong, Zifu Combes, Francis Sanders, Niek
