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Understanding the processes in a historically relevant thermal and mineral spring water by using mixing and inverse geoc...

Published in Environmental geochemistry and health

The thermal mineral water of Peñón de los Baños spa (Mexico City) has been used for over 500 years starting in pre-Hispanic times and is famous for the treatment of various pathologies. It has a temperature of 45 °C, which is rich in HCO3-, and its main trace elements are B, Li and Fe, which confers healing effects. Concerns about the sustainabilit...

North Carolina public school teachers' contact patterns and mask use within and outside of school during the prevaccine ...

Published in American journal of infection control

Teachers are central to school-associated transmission networks, but little is known about their behavioral patterns during the COVID-19 pandemic. We conducted a cross-sectional survey of 700 North Carolina public school teachers in 4 districts open to in-person learning in November-December 2020 (pre-COVID-19 vaccines). We assessed indoor and outd...

Pore-Scale Mechanisms for Spectral Induced Polarization of Calcite Precipitation Inferred from Geo-Electrical Millifluid...

Spectral induced polarization (SIP) has the potential for monitoring reactive processes in the subsurface. While strong SIP responses have been measured in response to calcite precipitation, their origin and mechanism remain debated. Here we present a novel geo-electrical millifluidic setup designed to observe microscale reactive transport processe...

Evaluation of the importance of mixing during preparation of antibiotic infusions.

Published in BMC pharmacology & toxicology

The mixing step after medication addition to the infusion bag is frequently omitted during the preparation of drug infusions. However, the importance of mixing when preparing antibiotic infusions is still unknown. The primary aim of this study was to assess the importance of the mixing step by comparing the concentrations of unmixed antibiotic infu...

Stress Factors in Protein Drug Product Manufacturing and Their Impact on Product Quality.

Published in Journal of pharmaceutical sciences

Injectable protein-based medicinal products (drug products, or DPs) must be produced by using sterile manufacturing processes to ensure product safety. In DP manufacturing the protein drug substance, in a suitable final formulation, is combined with the desired primary packaging (e.g., syringe, cartridge, or vial) that guarantees product integrity ...

Inference for extremal regression with dependent heavy-tailed data

Nonparametric inference on tail conditional quantiles and their least squares analogs, expectiles, remains limited to i.i.d. data. Expectiles are themselves quantiles of a transformation of the underlying distribution. We develop a fully operational kernel-based inferential theory for extreme conditional quantiles and expectiles in the challenging ...

Substitution of baking powders in a pound cake by an overpressure mixing process; impact on cake properties

This study concerns the mixing under gas pressure of a cake batter free from baking powder. Mixing the batter under pressure has been considered as an alternative to baking powder with the aim of forcing the aeration of the batter and possibly the solubilization of gas in the liquid phase of the batter. A prototype mixer was used with air, CO2 and ...

Investigating nucleation and growth phenomena in microfluidic supercritical antisolvent process by coupling in situ fluo...

High-pressure microfluidic systems exhibit favorable capacity to enhance mixing quality compared to conventional macroscale liquid systems. These mixing conditions are very interesting for the preparation of fluorescent organic nanoparticles by supercritical antisolvent process. In this work, fundamental mechanisms of microfluidic supercritical ant...