Li, Qiong Zhang, Wei Li, Jiali Xiong, Jingkang Liu, Jia Chen, Ting Wen, Qin Zeng, Yunjing Gao, Li Gao, Lei
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Published in
Biomarker Research
BackgroundThe early detection of tumors upon initial diagnosis or during routine surveillance is important for improving survival outcomes. Here, we investigated the feasibility and clinical significance of circulating tumor DNA (ctDNA) detection for Extranodal NK/T-cell lymphoma, nasal type (ENTKL).MethodsThe plasma ctDNA assessment was based on b...
Ching, Travers Duncan, Megan E. Newman-Eerkes, Tera McWhorter, Mollie M. E. Tracy, Jeffrey M. Steen, Michelle S. Brown, Ryan P. Venkatasubbarao, Srivatsa Akers, Nicholas K. Vignali, Marissa
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Published in
BMC Cancer
BackgroundThe clonoSEQ® Assay (Adaptive Biotechnologies Corporation, Seattle, USA) identifies and tracks unique disease-associated immunoglobulin (Ig) sequences by next-generation sequencing of IgH, IgK, and IgL rearrangements and IgH-BCL1/2 translocations in malignant B cells. Here, we describe studies to validate the analytical performance of the...
Helbig, Daniel Quesada, Andres E. Xiao, Wenbin Roshal, Mikhail Tallman, Martin S. Knorr, David A.
Published in
Journal of Hematology
Although rare, spontaneous remission (SR) of acute myeloid leukemia (AML) has been reported in the literature, the underlying mechanisms driving remission remain unknown. However, it is most commonly associated with a preceding severe infection. We present a case of a 40-year-old man with no past medical history who presented to our hospital with s...
Crowgey, Erin L. Mahajan, Nitin Wong, Wing Hing Gopalakrishnapillai, Anilkumar Barwe, Sonali P. Kolb, E. Anders Druley, Todd E.
Published in
BMC Medical Genomics
BackgroundPediatric leukemias have a diverse genomic landscape associated with complex structural variants, including gene fusions, insertions and deletions, and single nucleotide variants. Routine karyotype and fluorescence in situ hybridization (FISH) techniques lack sensitivity for smaller genomic alternations. Next-generation sequencing (NGS) a...
Barsan, Valentin Ramakrishna, Sneha Davis, Kara L.
Published in
Current Oncology Reports
Purpose of ReviewImmunotherapy for the treatment of acute lymphoblastic leukemia (ALL) broadens therapeutic options beyond chemotherapy and targeted therapy. Here, we review the use of monoclonal antibody-based drugs and cellular therapies to treat ALL. We discuss the challenges facing the field regarding the optimal timing and sequencing of these ...
Meraj, Fatima Jabbar, Naeem Nadeem, Kishwer Taimoor, Momal Mansoor, Neelum
Published in
Pakistan Journal of Medical Sciences
Objective: To determine frequency of post induction and post consolidation minimal residual disease (MRD) in pediatric B-lymphoblastic leukemia (B-ALL) patients and its association with clinical risk factors. Methods: This is a retrospective, cross sectional study carried out at the Indus Hospital on paediatric patients (1-17 years) was performed f...
Lim, Zuan-Fu Ma, Patrick C.
Published in
Journal of Hematology & Oncology
The biggest hurdle to targeted cancer therapy is the inevitable emergence of drug resistance. Tumor cells employ different mechanisms to resist the targeting agent. Most commonly in EGFR-mutant non-small cell lung cancer, secondary resistance mutations on the target kinase domain emerge to diminish the binding affinity of first- and second-generati...
Sędek, Łukasz Theunissen, Prisca Sobral da Costa, Elaine van der Sluijs-Gelling, Alita Mejstrikova, Ester Gaipa, Giuseppe Sonsala, Alicja Twardoch, Magdalena Oliveira, Elen Novakova, Michaela
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Published in
Journal of immunological methods
Optimal discrimination between leukemic blasts and normal B-cell precursors (BCP) is critical for treatment monitoring in BCP acute lymphoblastic leukemia (ALL); thus identification of markers differentially expressed on normal BCP and leukemic blasts is required. Multicenter analysis of CD73, CD86 and CD304 expression levels was performed in 282 p...
Chao, Nelson J
Published in
Best practice & research. Clinical haematology
Allogeneic hematopoietic stem cell transplantation (HSCT) has the potential for providing a cure for several hematologic malignancies. Although in most circumstances, allogeneic HSCT is preceded by disease-directed or cytoreductive therapy, it is unclear if these toxic conditioning regimens can be circumvented. This review summarizes evidence that ...
Bai, Yinlei Chim, Chor Sang
Published in
Hematology (Amsterdam, Netherlands)
Buffy coat and ficoll of bone marrow (BM) are viable options for the study of minimal residual disease (MRD) in multiple myeloma (MM). As yet, there is no data about the superiority of either sample types. Herein, we aimed to address this issue. Forty pairs of ficolled BMs and BM buffy coats of 19 MM patients were studied for MRD by allele-specific...
