Published in Cancer Cell International
BackgroundGlioma is the most common central nervous system (CNS) tumour. p62, an important autophagy adaptor, plays a crucial role in cancer. However, the role of p62 in the progression of glioma is poorly characterized.MethodsWe examined the expression of p62 in glioma tissues and cell lines. Then we investigated the function of p62 in vitro, and ...
Published in Journal of Experimental & Clinical Cancer Research
BackgroundThe first line therapy for patients with diffuse large B cell (DLBCL) is R-CHOP. About half of DLBCL patients are either refractory to, or will relapse, after the treatment. Therefore, identifying novel drug targets and effective therapeutic agents is urgently needed for improving DLBCL patient survival. b-AP15, a selective small molecule...
Published in Applied Biological Chemistry
Heavy metals including Lead (Pb), Cadmium (Cd), Arsenic (As) and Aluminium (Al) were analysed in oilseeds, noodles, tea leaves and their processed or cooked products to study the effects of food processing methods on migration of heavy metals. The heavy metals were determined with ICP-MS and ICP-OES following microwave-assisted acid digestion. Heav...
Published in Movement Ecology
BackgroundAlthough many aspects of passerine migration are genetically determined, routing appears to be flexibly adjusted to the conditions experienced on each individual journey. This holds especially true for routing decisions taken when confronted with large bodies of water. Once taken, these decisions can be hardly altered or revised. In this ...
Published in Archives of biochemistry and biophysics
To identify the relationship between Histone deacetylase 3 (HDAC3) and Human epididymis protein 4 (HE4) and to explore the mechanisms underlying their effects on the malignant behaviors of ovarian carcinoma cells. The expression levels of HDAC3 in ovarian carcinoma tissues were identified by immunohistochemistry, Western blot and real-time PCR. A w...
Published in Raumforschung und Raumordnung Spatial Research and Planning
Die neue Migrationsvielfalt und zunehmende Diversifizierung unserer Gesellschaft verändert urbane Räume. In den von Migration besonders geprägten Ankunftsräumen konzentrieren sich auch in erhöhtem Ausmaß von Armut betroffene Haushalte mit und ohne Migrationshintergrund. Dieser Quartierstypus, häufig als „Migrantenviertel" oder „ethnische Kolonie" b...
Published in Raumforschung und Raumordnung Spatial Research and Planning
Der Beitrag untersucht die Stadtentwicklungsstrategien von Bremen und Leipzig im Hinblick auf ihren Umgang mit Migration. Die Leitfragen des Beitrages sind folgende: Auf welche Zielgruppen der Migration setzen die Stadtentwicklungspolitiken, um Wachstumsziele zu erreichen? Inwieweit erfolgt ein Perspektivenwechsel auf Migration vom Problem zum Pote...
Published in Molecular Medicine
BackgroundClub Cell protein (CC)16 correlates with lung injury and respiratory complications, which are in part triggered by polymorphonuclear leukocytes (PMNL) in severely traumatized patients (TP). CC16 exerts anti-inflammatory and immunosuppressive effects, however, its influence on PMNL functions after trauma is unknown. Here, we evaluated whet...
Published in Cancer immunology, immunotherapy : CII
Hepatic stellate cells (HSCs) are important stromal cells and pivotal mediators involved in the pathogenesis and immunosuppression of hepatocellular carcinoma (HCC). The liver has been demonstrated to be a site for accumulation of tumor-induced myeloid-derived suppressor cells (MDSCs). We previously reported that HSCs induced an increase in the num...
Published in BMC Cancer
BackgroundNicotinic acetylcholine receptors (nAChRs) have been reported to be overexpressed in malignancies in humans and is associated with tumorigenesis and cell migration. In previous studies of gastric cancer, alpha7 nicotinic acetylcholine receptor (α7-nAChR) overexpression leads to epithelial-mesenchymal transition (EMT) and promotes the migr...
