Li, Yi Wang, Mengyao Liu, Xue Rong, Jian Miller, Patricia Joehanes, Roby Huan, Tianxiao Guo, Xiuqing Rotter, Jerome Smith, Jennifer
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BACKGROUND: Metabolite signatures of long-term alcohol consumption are lacking. To better understand the molecular basis linking alcohol drinking and cardiovascular disease (CVD), we investigated circulating metabolites associated with long-term alcohol consumption and examined whether these metabolites were associated with incident CVD. METHODS: C...
Adhikari, Neill KJ Hashmi, Madiha Tirupakuzhi Vijayaraghavan, Bharath Kuma... Haniffa, Rashan Beane, Abi Webb, Steve A Angus, Derek C Gordon, Anthony C Cook, Deborah J Guyatt, Gordon H
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IMPORTANCE: The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain. OBJECTIVE: To determine whether vitamin C improves outcomes for patients with COVID-19. DESIGN, SETTING, AND PARTICIPANTS: Two prospectively harmonized randomized clinical trials enrolled critically ill patients receiving organ support in intensive care unit...
Tin, Adrienne Fohner, Alison Yang, Qiong Brody, Jennifer Davies, Gail Yao, Jie Liu, Dan Caro, Ilana Lindbohm, Joni Duggan, Michael
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Identifying circulating proteins associated with cognitive function may point to biomarkers and molecular process of cognitive impairment. Few studies have investigated the association between circulating proteins and cognitive function. We identify 246 protein measures quantified by the SomaScan assay as associated with cognitive function (p
George, Kristen Gilsanz, Paola Meunier, Claire Peterson, Rachel Hayes-Larson, Eleanor Barnes, Lisa Mungas, Dan Whitmer, Rachel Lor, Yi
OBJECTIVES: Adverse childhood experiences (ACEs) are associated with higher risk of chronic disease, but little is known about the association with late life cognitive decline. We examined the longitudinal association between ACEs and late-life cognitive decline in the Study of Healthy Aging in African Americans (STAR). DESIGN: Linear mixed models ...
Bruce, Lauryn Kasl, Patrick Soltani, Severine Viswanath, Varun Hartogensis, Wendy Dilchert, Stephan Hecht, Frederick Chowdhary, Anoushka Anglo, Claudine Pandya, Leena
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BACKGROUND: Females have been historically excluded from biomedical research due in part to the documented presumption that results with male subjects will generalize effectively to females. This has been justified in part by the assumption that ovarian rhythms will increase the overall variance of pooled random samples. But not all variance in sam...
Noh, Sharon Singla, Umesh Bennett, Ilana Bornstein, Aaron
Memory function declines in normal aging, in a relatively continuous fashion following middle-age. The effect of aging on decision-making is less well-understood, with seemingly conflicting results on both the nature and direction of these age effects. One route for clarifying these mixed findings is to understand how age-related differences in mem...
Liu, Xianchen Li, Benjamin McRoy, Lynn Chen, Connie Layman, Rachel Brufsky, Adam Rugo, Hope
BACKGROUND: Disparities in survival and clinical outcomes between African American and White patients with breast cancer (BC) are well documented, but African American patients have not been well represented in randomized clinical trials of CDK4/6 inhibitors. Real-world studies can provide evidence for effective treatment strategies for underreport...
Vivian, Lisa Francesca; Marcelis, Lukas; Leoni, Eleonora; De Bruecker, Yves; Maes, Helena; Pierre, Erwin; Ballaux, Florence M; Tousseyn, Thomas; 42009;
BACKGROUND AL amyloidomas are solitary, localized, tumor-like deposits of immunoglobulin light-chain-derived amyloid fibrils in the absence of systemic amyloidosis. A rare entity, they have been described in various anatomical sites, typically in spatial association with a sparse lymphoplasmacytic infiltrate, ultimately corresponding to a clonal, m...
Morales-Rodriguez, Denisse Anderson, Annika Hsu, Stephanie Singh, Jessica Rowles, Will Walsh, Christine Braley, Tiffany Bove, Riley Nylander, Alyssa
BACKGROUND: A majority of women with multiple sclerosis (MS) are diagnosed prior to menopause, yet their experiences during this transition are not well characterized. OBJECTIVES: To explore associations between mental health, sleep, and other quality of life metrics, and vasomotor symptoms (VMSs) in ambulatory, menopausal women with MS. METHODS: A...
Carlson, Gwendolyn Fung, Constance Josephson, Karen Song, Yeonsu Swistun, Dominika Zhu, Ruoyan Mitchell, Michael Lee, Diane Badr, M Washington, Donna
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PURPOSE: Sleep-disordered breathing (SDB) is a common sleep disorder in veterans; however, limited research exists in women veterans. We sought to estimate patterns of care in terms of evaluation, diagnosis, and treatment among women veterans with factors associated with elevated SDB risk. METHODS: Within one VA healthcare system, women identified ...