Xu, Pengfei Hong, Ye Xie, Yi Yuan, Kang Li, Juanji Sun, Rui Zhang, Xiaohao Shi, Xiaolei Li, Rongrong Wu, Jiaonan
...
Published in
Translational stroke research
Neuroinflammation contributes to the pathogenesis of early brain injury induced by subarachnoid hemorrhage (SAH). Previous reports have demonstrated that triggering receptor expressed on myeloid cells 1 (TREM-1) regulates inflammatory response caused by ischemic stroke or myocardial infarction. However, whether TREM-1 could modulate neuroinflammati...
Jing, Feng Zou, Qian Wang, Yangyang Cai, Zhiyou Tang, Yong
Published in
The Journal of Headache and Pain
BackgroundCentral sensitization is considered a critical pathogenic mechanism of chronic migraine (CM). Activation of microglia in the trigeminal nucleus caudalis (TNC) contributes to this progression. Microglial glucagon-like peptide-1 receptor (GLP-1R) activation can alleviate pain; however, whether it is involved in the mechanism of CM has not b...
Spiteri, Alanna G. Terry, Rachel L. Wishart, Claire L. Ashhurst, Thomas M. Campbell, Iain L. Hofer, Markus J. King, Nicholas J. C.
Published in
Journal of Neuroinflammation
BackgroundDifferentiating infiltrating myeloid cells from resident microglia in neuroinflammatory disease is challenging, because bone marrow-derived inflammatory monocytes infiltrating the inflamed brain adopt a ‘microglia-like’ phenotype. This precludes the accurate identification of either cell type without genetic manipulation, which is importa...
Takahashi, Kei Nakamura, Shinsuke Otsu, Wataru Shimazawa, Masamitsu Hara, Hideaki
Published in
Journal of Neuroinflammation
BackgroundAge-related macular degeneration (AMD) is the principal cause of permanent blindness among elderly individuals worldwide. Chronic inflammation in the subretinal space is associated with a progression of exudative AMD. Progranulin (PGRN) is a growth factor secreted from myeloid cells and plays an important role in controlling the lysosomal...
Dodd, William S. Noda, Imaray Martinez, Melanie Hosaka, Koji Hoh, Brian L.
Published in
Journal of Neuroinflammation
BackgroundThe NLRP3 inflammasome is a critical mediator of several vascular diseases through positive regulation of proinflammatory pathways. In this study, we defined the role of NLRP3 in both the acute and delayed phases following subarachnoid hemorrhage (SAH). SAH is associated with devastating early brain injury (EBI) in the acute phase, and th...
De, Ishani Maklakova, Vilena Litscher, Suzanne Boyd, Michelle M. Klemm, Lucas C. Wang, Ziyue Kendziorski, Christina Collier, Lara S.
Published in
Journal of Neuroinflammation
BackgroundColony-stimulating factor 1 (CSF1) expression in the central nervous system (CNS) increases in response to a variety of stimuli, and CSF1 is overexpressed in many CNS diseases. In young adult mice, we previously showed that CSF1 overexpression in the CNS caused the proliferation of IBA1+ microglia without promoting the expression of M2 po...
Fullard, John F. Lee, Hao-Chih Voloudakis, Georgios Suo, Shengbao Javidfar, Behnam Shao, Zhiping Peter, Cyril Zhang, Wen Jiang, Shan Corvelo, André
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Published in
Genome Medicine
BackgroundCoronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has been associated with neurological and neuropsychiatric illness in many individuals. We sought to further our understanding of the relationship between brain tropism, neuro-inflammation, and host immune response in acu...
Weston, Lea L. Jiang, Shanya Chisholm, Devon Jantzie, Lauren L. Bhaskar, Kiran
Published in
Journal of Neuroinflammation
BackgroundThe presence of hyperphosphorylated microtubule-associated protein tau is strongly correlated with cognitive decline and neuroinflammation in Alzheimer’s disease and related tauopathies. However, the role of inflammation and anti-inflammatory interventions in tauopathies is unclear. Our goal was to determine if removing anti-inflammatory ...
Xiao, Jie Cai, Tao Fang, Yuanjian Liu, Rui Flores, Jerry J. Wang, Wenna Gao, Ling Liu, Yu Lu, Qin Tang, Lihui
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Published in
Journal of Neuroinflammation
BackgroundGerminal matrix hemorrhage (GMH) is defined by the rupture of immature blood vessels in the germinal matrix, where subsequent hemorrhage enters the subependymal zone and the cerebral lateral ventricles. The consequent blood clot has been identified as the causative factor of secondary brain injury, which triggers a series of complex paral...
Koo, Ja Wook Wohleb, Eric S
Published in
Biological psychiatry
Chronic stress causes physiological and hormonal adaptations that lead to neurobiological consequences and behavioral and cognitive impairments. In particular, chronic stress has been shown to drive reduced neurogenesis and altered synaptic plasticity in brain regions that regulate mood and motivation. The neurobiological and behavioral effects of ...
