Long, Ting He, Wei Pan, Qi Zhang, Shanshan Zhang, Dunke Qin, Guangcheng Chen, Lixue Zhou, Jiying
Published in
The Journal of Headache and Pain
BackgroundAccording to our previous study, microglia P2X4 receptors (P2X4Rs) play a pivotal role in the central sensitization of chronic migraine (CM). However, the molecular mechanism that underlies the crosstalk between microglia P2X4Rs and neurons of the trigeminal nucleus caudalis (TNC) is not fully understood. Therefore, the aim of this study ...
Ding, Honglu Chen, Jialiang Su, Minzhi Lin, Zhijun Zhan, Hailun Yang, Fei Li, Wenbiao Xie, Juncong Huang, Yong Liu, Xianguo
...
Published in
Journal of Neuroinflammation
BackgroundPatients with interstitial cystitis/bladder pain syndrome (IC/BPS) often grieve over a low quality of life brought about by chronic pain. In our previous studies, we determined that neuroinflammation of the spinal dorsal horn (SDH) was associated with mechanisms of interstitial cystitis. Moreover, it has been shown that brain-derived neur...
Ye, Xiaoxia Zhu, Mingming Che, Xiaohang Wang, Huiyang Liang, Xing-Jie Wu, Chunfu Xue, Xue Yang, Jingyu
Published in
Journal of Neuroinflammation
BackgroundMicroglial activation is a prominent feature of neuroinflammation, which is present in almost all neurodegenerative diseases. While an initial inflammatory response mediated by microglia is considered to be protective, excessive pro-inflammatory response of microglia contributes to the pathogenesis of neurodegeneration. Although autophagy...
El Gaamouch, Farida Audrain, Mickael Lin, Wei-Jye Beckmann, Noam Jiang, Cheng Hariharan, Siddharth Heeger, Peter S. Schadt, Eric E. Gandy, Sam Ehrlich, Michelle E.
...
Published in
Molecular Neurodegeneration
BackgroundMultiomic studies by several groups in the NIH Accelerating Medicines Partnership for Alzheimer’s Disease (AMP-AD) identified VGF as a major driver of Alzheimer’s disease (AD), also finding that reduced VGF levels correlate with mean amyloid plaque density, Clinical Dementia Rating (CDR) and Braak scores. VGF-derived peptide TLQP-21 activ...
Shao, Shuai Xia, Huan Hu, Min Chen, Chengjuan Fu, Junmin Shi, Gaona Guo, Qinglan Zhou, Yu Wang, Wenjie Shi, Jiangong
...
Published in
Journal of Neuroinflammation
BackgroundIsotalatizidine is a representative C19-diterpenoid alkaloid extracted from the lateral roots of Aconitum carmichaelii, which has been widely used to treat various diseases on account of its analgesic, anti-inflammatory, anti-rheumatic, and immunosuppressive properties. The aim of this study was to evaluate the analgesic effect of isotala...
Wang, JiaJia Li, YanJun Lai, Ke Zhong, QiMei Demin, Konstantin A Kalueff, Allan V Song, Cai
Published in
Progress in neuro-psychopharmacology & biological psychiatry
Neuroinflammation and metabolic deficits contribute to the etiology of human affective disorders, such as anxiety and depression. The zebrafish (Danio rerio) has recently emerged as a powerful new model organism in CNS disease modeling. Here, we exposed zebrafish to 2% glucose and 10% cholesterol for 19 days to experimentally induce type 2 diabetes...
Zhang, Shutian Hu, Li Jiang, Jialun Li, Hongji Wu, Qin Ooi, Kokwin Wang, Jijiang Feng, Yi Zhu, Danian Xia, Chunmei
...
Published in
Journal of Neuroinflammation
BackgroundMicroglial mediated neuroinflammation in the rostral ventrolateral medulla (RVLM) plays roles in the etiology of stress-induced hypertension (SIH). It was reported that autophagy influenced inflammation via immunophenotypic switching of microglia. High-mobility group box 1 (HMGB1) acts as a regulator of autophagy and initiates the product...
Das, Rashmi Balmik, Abhishek Ankur Chinnathambi, Subashchandrabose
Published in
Journal of Neuroinflammation
BackgroundAlzheimer’s disease is associated with the accumulation of intracellular Tau tangles within neurons and extracellular amyloid-β plaques in the brain parenchyma, which altogether results in synaptic loss and neurodegeneration. Extracellular concentrations of oligomers and aggregated proteins initiate microglial activation and convert their...
Datta, Dibyadeep Leslie, Shannon N. Morozov, Yury M. Duque, Alvaro Rakic, Pasko van Dyck, Christopher H. Nairn, Angus C. Arnsten, Amy F. T.
Published in
Journal of Neuroinflammation
BackgroundCognitive impairment in schizophrenia, aging, and Alzheimer’s disease is associated with spine and synapse loss from the dorsolateral prefrontal cortex (dlPFC) layer III. Complement cascade signaling is critical in driving spine loss and disease pathogenesis. Complement signaling is initiated by C1q, which tags synapses for elimination. C...
Vargas-Caraveo, Alejandra Sayd, Aline Robledo-Montaña, Javier Caso, Javier R. Madrigal, José L. M. García-Bueno, Borja Leza, Juan C.
Published in
Journal of Neuroinflammation
BackgroundThe circumventricular organs (CVOs) are blood-brain-barrier missing structures whose activation through lipopolysaccharide (LPS) is a starting point for TLR-driven (Toll-like receptors) neuroinflammation. The aim of this study was to evaluate in the CVO area postrema (AP), subfornical organ (SFO), and median eminence (ME), the inflammator...
