Matsuda, Taito Nakashima, Kinichi
Published in
Neuroscience research
Neural stem cells (NSCs) in the adult hippocampus generate new neurons via a process referred to as neurogenesis, supporting cognitive functions. Since altered neurogenesis has been reportedly associated with several diseases such as epilepsy, the molecular basis of NSC activity is an important focus in the study of neurogenesis. Furthermore, facil...
Nanjundaiah, Shwetha Chidambaram, Hariharakrishnan Chandrashekar, Madhura Chinnathambi, Subashchandrabose
Published in
Cellular and molecular neurobiology
Cholesterol, a principal constituent of the cell membrane, plays a crucial role in the brain by regulating the synaptic transmission, neuronal signaling, as well as neurodegenerative diseases. Defects in the cholesterol trafficking are associated with enhanced generation of hyperphosphorylated Tau and Amyloid-β protein. Tau, a major microtubule-ass...
Tan, Yinyin Zheng, Yanqun Xu, Daiwen Sun, Zhanfang Yang, Huan Yin, Qingqing
Published in
Cell & Bioscience
Alzheimer’s disease (AD) is the most common cause of dementia and is characterized by the deposition of extracellular aggregates of amyloid-β (Aβ), the formation of intraneuronal tau neurofibrillary tangles and microglial activation-mediated neuroinflammation. One of the key molecules involved in microglial activation is galectin-3 (Gal-3). In rece...
O’Regan, Grace C. Farag, Sahar H. Casey, Caroline S. Wood-Kaczmar, Alison Pocock, Jennifer M. Tabrizi, Sarah J. Andre, Ralph
Published in
Journal of Neuroinflammation
BackgroundNeuroinflammation may contribute to the pathogenesis of Huntington’s disease, given evidence of activated microglia and elevated levels of inflammatory molecules in disease gene carriers, even those many years from symptom onset. We have shown previously that monocytes from Huntington’s disease patients are hyper-reactive to stimulation i...
Rabaneda-Lombarte, Neus Serratosa, Joan Bové, Jordi Vila, Miquel Saura, Josep Solà, Carme
Published in
Journal of Neuroinflammation
BackgroundIt is suggested that neuroinflammation, in which activated microglial cells play a relevant role, contributes to the development of Parkinson’s disease (PD). Consequently, the modulation of microglial activation is a potential therapeutic target to be taken into account to act against the dopaminergic neurodegeneration occurring in this n...
Magno, Lorenza Bunney, Tom D. Mead, Emma Svensson, Fredrik Bictash, Magda N.
Published in
Molecular Neurodegeneration
The central role of the resident innate immune cells of the brain (microglia) in neurodegeneration has become clear over the past few years largely through genome-wide association studies (GWAS), and has rapidly become an active area of research. However, a mechanistic understanding (gene to function) has lagged behind. That is now beginning to cha...
Singhal, Gaurav Morgan, Julie Corrigan, Frances Toben, Catherine Jawahar, Magdalene C Jaehne, Emily J Manavis, Jim Hannan, Anthony J Baune, Bernhard T
Published in
Cellular and molecular neurobiology
Physical exercise (PE) and environmental enrichment (EE) can modulate immunity. However, the differential effects of short-term PE, EE, and PE + EE on neuroimmune mechanisms during normal aging has not been elucidated. Hence, a cohort of 3-, 8-, and 13-month-old immunologically unchallenged C57BL/6 wild-type mice were randomly assigned to either Co...
Spellicy, Samantha E Stice, Steven L
Published in
Stem cell reviews and reports
Extracellular vesicles (EVs), nano- to micro- sized vesicles released from cells, have garnered attention in recent years for their role in intercellular communication. Specifically, EVs from various cell sources including stem cells, have shown to have an exacerbatory or therapeutic effect in the content of pro- and anti-inflammatory environments ...
Yu, Han Xu, Zhihong Qu, Gaojing Wang, Huimin Lin, Lulu Li, Xianyu Xie, Xiaolin Lei, Yifeng He, Xiaohua Chen, Yun
...
Published in
Cellular and molecular neurobiology
Activation of pro-inflammatory microglia is an important mechanism of the cerebral ischemia-reperfusion (I/R)-induced neuronal injury and dysfunction. Mesenchymal stem cells (MSCs) together with their paracrine factors demonstrated curative potential in immune disorders and inflammatory diseases, as well as in ischemic diseases. However, it remains...
Kimura, Tomoka Toriuchi, Kohki Kakita, Hiroki Tamura, Tetsuya Takeshita, Satoru Yamada, Yasumasa Aoyama, Mineyoshi
Published in
Cellular and molecular neurobiology
Although therapeutic hypothermia (TH) provides neuroprotection, the cellular mechanism underlying the neuroprotective effect of TH has not yet been fully elucidated. In the present study, we investigated the effect of TH on microglial activation to determine whether hypothermia attenuates neuronal damage via microglial activation. After lipopolysac...
