Hayashida, Emina Ling, Zheng Lung Ashhurst, Thomas M. Viengkhou, Barney Jung, So Ri Songkhunawej, Pattama West, Phillip K. King, Nicholas J. C. Hofer, Markus J.
Published in
Journal of Neuroinflammation
BackgroundUntil the end of the twentieth century, Zika virus (ZIKV) was thought to cause a mostly mild, self-limiting disease in humans. However, as the geographic distribution of ZIKV has shifted, so too has its pathogenicity. Modern-day ZIKV infection is now known to cause encephalitis, acute disseminated encephalomyelitis, and Guillain-Barré syn...
Kobayashi, Kaoru Umeda, Kousuke Ihara, Fumiaki Tanaka, Sachi Yamagishi, Junya Suzuki, Yutaka Nishikawa, Yoshifumi
Published in
BMC Genomics
BackgroundInfection with Toxoplasma gondii is thought to damage the brain and be a risk factor for neurological and psychotic disorders. The immune response-participating chemokine system has recently been considered vital for brain cell signaling and neural functioning. Here, we investigated the effect of the deficiency of C-C chemokine receptor 5...
Ni, Junjun Wu, Zhou Meng, Jie Saito, Takashi Saido, Takaomi C. Qing, Hong Nakanishi, Hiroshi
Published in
Journal of Neuroinflammation
BackgroundDisturbances in clock genes affect almost all patients with Alzheimer’s disease (AD), as evidenced by their altered sleep/wake cycle, thermoregulation, and exacerbation of cognitive impairment. As microglia-mediated neuroinflammation proved to be a driver of AD rather than a result of the disease, in this study, we evaluated the relations...
Yang, Hongtian Graham, Leah C. Reagan, Alaina M. Grabowska, Weronika A. Schott, William H. Howell, Gareth R.
Published in
Journal of Neuroinflammation
BackgroundEnvironmental factors are critical in the development of age-related cognitive decline and dementia. A western diet (WD) can cause nutrient deficiency and inflammation that could impact cognition directly. It is increasingly recognized that innate immune responses by brain myeloid cells, such as resident microglia, and infiltrating periph...
Peng, Jiyun Liu, Yong Umpierre, Anthony D. Xie, Manling Tian, Dai-Shi Richardson, Jason R. Wu, Long-Jun
Published in
Molecular Brain
The P2Y12 receptor (P2Y12R) is a purinoceptor that is selectively expressed in microglia in the central nervous system. As a signature receptor, microglial P2Y12R mediates process chemotaxis towards ADP/ATP gradients and is engaged in several neurological diseases including chronic pain, stroke and seizures. However, the role of microglial P2Y12R i...
George, Sonia Rey, Nolwen L. Tyson, Trevor Esquibel, Corinne Meyerdirk, Lindsay Schulz, Emily Pierce, Steven Burmeister, Amanda R. Madaj, Zachary Steiner, Jennifer A.
...
Published in
Molecular Neurodegeneration
BackgroundCell-to-cell propagation of α-synuclein (α-syn) aggregates is thought to contribute to the pathogenesis of Parkinson’s disease (PD) and underlie the spread of α-syn neuropathology. Increased pro-inflammatory cytokine levels and activated microglia are present in PD and activated microglia can promote α-syn aggregation. However, it is uncl...
Gupta, Muskan Kaur, Gurcharan
Published in
BMC Complementary and Alternative Medicine
BackgroundSystemic inflammation driven neuroinflammation is an event which correlates with pathogenesis of several neurodegenerative diseases. Therefore, targeting peripheral and central inflammation simultaneously could be a promising approach for the management of these diseases. Nowadays, herbal medicines are emerging as potent therapeutics agai...
Lenz, Maximilian Vlachos, Andreas
Published in
Neuroforum
Mikroglia sind Zellen des angeborenen Immunsystems im zentralen Nervensystem, die eine bedeutende Rolle bei entzündlichen Veränderungen im Nervengewebe spielen. Ursprünglich galt die Annahme, dass Mikrogliazellen ihre Funktion erst nach Aktivierung durch pathologische Stimuli aufnehmen. Neuere Studien deuten darauf hin, dass Mikroglia physiologisch...
Krämer, Tobias J. Hack, Nathalia Brühl, Till J. Menzel, Lutz Hummel, Regina Griemert, Eva-Verena Klein, Matthias Thal, Serge C. Bopp, Tobias Schäfer, Michael K. E.
...
Published in
Journal of Neuroinflammation
BackgroundTraumatic brain injury (TBI) is a major cause of death and disability. T cells were shown to infiltrate the brain during the first days after injury and to exacerbate tissue damage. The objective of this study was to investigate the hitherto unresolved role of immunosuppressive, regulatory T cells (Tregs) in experimental TBI.Methods“Deple...
Westhoff, D. Engelen-Lee, J. Y. Hoogland, I. C. M. Aronica, E. M. A. van Westerloo, D. J. van de Beek, D. van Gool, W. A.
Published in
Immunity & Ageing
BackgroundSystemic infection is associated with long-term cognitive deficits and functional decline. In this study we hypothesized that severe systemic inflammation leads to a neuroinflammatory response that is characterized by microglial activation, and that these effects might be more pronounced in patients using medication with anticholinergic s...
