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Self-Digitization Dielectrophoretic (SD-DEP) Chip for High Efficiency Single-Cell Capture, On-Demand Compartmentalizatio...

Published in Angewandte Chemie (International ed. in English)

Self-digitization dielectrophoretic (SD-DEP) chip was designed by employing the traditional DEP and insulator DEP to create the local electric field for single-cell manipulation and downstream nucleic acid analysis. The multistep procedures of cell manipulation, lysis, and chemical analysis were performed in the integrated microdevice, consuming mi...

Probing microfluidic devices using drug loaded nanocrystals in breast cancer studies

Drug carrier development is a financially taxing process. There are a plethora of ongoing studies in academia and industry aimed towards understanding and solving problems within every stage involved in drug discovery, design, and testing starting from the bench top in vitro continuing onwards to in vivo animal models and finally, concluding with F...

Air bubble resistant and disposable microPCR chip with a portable and programmable device for forensic test

Due to the difficulty in sample introduction, the presence of air bubbles and the complicated fabrication with high cost, there are no commercial products of microfluidic polymerase chain reaction (microPCR) on the market yet. In this study, an air bubble resistant and disposable microPCR chip was developed. A simple fabrication method using Norlan...

Designing Bioinspired Artificial Cilia to Regulate Particle-Surface Interactions.

Published in The journal of physical chemistry letters

Biological cilia play a critical role in a stunning array of vital functions, from enabling marine organisms to trap food and expel fouling agents to facilitating the effective transport of egg cells in mammals. Inspired by the performance of these microscopic, hair-like filaments, researchers are synthesizing artificial cilia for use in lab-on-a-c...

The structure of dynamic GPCR signaling networks

G-protein-coupled receptors (GPCRs) stimulate signaling networks that control a variety of critical physiological processes. Static information on the map of interacting signaling molecules at the basis of many cellular processes exists, but little is known about the dynamic operation of these networks. Here we focus on two questions. First, Is the...

Dispersion of a Nanoliter Bolus in Microfluidic Co-Flow.

Published in Journal of micromechanics and microengineering : structures, devices, and systems

Microfluidic systems enable reactions and assays on the scale of nanoliters. However, at this scale nonuniformities in sample delivery become significant. To determine the fundamental minimum sample volume required for a particular device, a detailed understanding of mass transport is required. Co-flowing laminar streams are widely used in many dev...