Qin, Y Wu, L Schneider, T Yen, GS Wang, J Xu, S Li, M Paguirigan, AL Smith, JL Radich, JP
...
Published in
Angewandte Chemie (International ed. in English)
Self-digitization dielectrophoretic (SD-DEP) chip was designed by employing the traditional DEP and insulator DEP to create the local electric field for single-cell manipulation and downstream nucleic acid analysis. The multistep procedures of cell manipulation, lysis, and chemical analysis were performed in the integrated microdevice, consuming mi...
JARVIS, MARIA ISABEL
Drug carrier development is a financially taxing process. There are a plethora of ongoing studies in academia and industry aimed towards understanding and solving problems within every stage involved in drug discovery, design, and testing starting from the bench top in vitro continuing onwards to in vivo animal models and finally, concluding with F...
Xu, Jiandong Lv, Xuefei Wei, Yuping Zhang, Liang Li, Rui Deng, Yulin Xu, Xia
Due to the difficulty in sample introduction, the presence of air bubbles and the complicated fabrication with high cost, there are no commercial products of microfluidic polymerase chain reaction (microPCR) on the market yet. In this study, an air bubble resistant and disposable microPCR chip was developed. A simple fabrication method using Norlan...
Balazs, Anna C Bhattacharya, Amitabh Tripathi, Anurag Shum, Henry
Published in
The journal of physical chemistry letters
Biological cilia play a critical role in a stunning array of vital functions, from enabling marine organisms to trap food and expel fouling agents to facilitating the effective transport of egg cells in mammals. Inspired by the performance of these microscopic, hair-like filaments, researchers are synthesizing artificial cilia for use in lab-on-a-c...
O'NEILL, PR GIRI, L KARUNARATHNE, WKA PATEL, AK VENKATESH, KV GAUTAM, N
G-protein-coupled receptors (GPCRs) stimulate signaling networks that control a variety of critical physiological processes. Static information on the map of interacting signaling molecules at the basis of many cellular processes exists, but little is known about the dynamic operation of these networks. Here we focus on two questions. First, Is the...
Conway, A J Saadi, W M Sinatra, F L Kowalski, G Larson, D Fiering, J
Published in
Journal of micromechanics and microengineering : structures, devices, and systems
Microfluidic systems enable reactions and assays on the scale of nanoliters. However, at this scale nonuniformities in sample delivery become significant. To determine the fundamental minimum sample volume required for a particular device, a detailed understanding of mass transport is required. Co-flowing laminar streams are widely used in many dev...
Forsberg, Fredrik Saharil, Farizah Haraldsson, Tommy Roxhed, Niclas Stemme, Göran van der Wijngaart, Wouter Niklaus, Frank
Adhesion energies are determined for three different polymers currently used in adhesive wafer bonding of silicon wafers. The adhesion energies of the polymer off-stoichiometry thiol-ene-epoxy OSTE+ and the nano-imprint resist mr-I 9150XP are determined. The results are compared to the adhesion energies of wafers bonded with benzocyclobutene, both ...
Karlsson, J. Mikael Haraldsson, Tommy Carlborg, Carl Fredrik Hansson, Jonas Russom, Aman van der Wijngaart, Wouter
We present a method for PDMS microfabrication of fragile membranes and 3D fluidic networks, using a surface modified water-dissolvable release material, poly(vinyl alcohol), as a tool for handling, transfer and release of fragile polymer microstructures. The method is well suited for the fabrication of complex multilayer microfluidic devices, here ...
Saha, Auro Ashish Mitra, Sushanta K. Tweedie, Mark Roy, Susanta McLaughlin, Jim
Published in
Microfluidics and Nanofluidics
Microfluidic channels with integrated pillars are fabricated on SU8 and PDMS substrates to understand the capillary flow. Microscope in conjunction with high-speed camera is used to capture the meniscus front movement through these channels for ethanol and isopropyl alcohol, respectively. In parallel, numerical simulations are conducted, using volu...