Buck, Jordan M O'Neill, Heidi C Stitzel, Jerry A
Published in
Behavior genetics
Maternal tobacco smoking during pregnancy constitutes developmental nicotine exposure (DNE) and is associated with nicotine dependence and neurodevelopmental disorders in both children and grandchildren as well as animal models thereof. Genetic variants such as the CHRNA5 single nucleotide polymorphism (SNP) rs16969968, which leads to an aspartic a...
Wang, Caiyun Jin, Cuiyuan Tu, Wenqing Jin, Yuanxiang
Published in
Endocrine journal
The toxicity of certain novel perfluoroalkyl substances (PFCs) has attracted increasing attention. However, the toxic effects of sodium p-perfluorous nonenoxybenzene sulfonate (OBS) on the endocrine system have not been elucidated. In this study, OBS was added to the drinking water during the pregnancy and lactation of the healthy female mice at di...
Mulorz, Joscha Shayan, Mahdis Hu, Caroline Alcazar, Cynthia Chan, Alex HP Briggs, Mason Wen, Yan Walvekar, Ankita P Ramasubramanian, Anand K Spin, Joshua M
...
Abdominal aortic aneurysm (AAA) is associated with the loss of vascular smooth muscle cells (SMCs) within the vessel wall. Direct delivery of therapeutic cells is challenging due to impaired mechanical integrity of the vessel wall. We hypothesized that porous collagen scaffolds can be an effective vehicle for the delivery of human-derived SMCs to t...
Suryawanshi, Gajendra W Arokium, Hubert Kim, Sanggu Khamaikawin, Wannisa Lin, Samantha Shimizu, Saki Chupradit, Koollawat Lee, YooJin Xie, Yiming Guan, Xin
...
BackgroundCurrent understanding of hematopoiesis is largely derived from mouse models that are physiologically distant from humans. Humanized mice provide the most physiologically relevant small animal model to study human diseases, most notably preclinical gene therapy studies. However, the clonal repopulation dynamics of human hematopoietic stem ...
Bakken, Trygve E Jorstad, Nikolas L Hu, Qiwen Lake, Blue B Tian, Wei Kalmbach, Brian E Crow, Megan Hodge, Rebecca D Krienen, Fenna M Sorensen, Staci A
...
The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally conserved across mammals1. Here, using high-throughput transcriptomic and epigenomic profiling of more than 450,000 single nuclei in humans, marmoset monkeys and mice, we demonstrate a broadly conserved cellular makeup of this region, with similarities t...
Murphy, William J
The rapid development and application of different SARS-Cov2 vaccines world-wide has resulted in impressive efficacy and protection from this deadly pandemic. However, the existence of different and continuously developing vaccine candidates coupled with the likelihood of continued application due to both waning immune responses and emergence of vi...
Besaratinia, Ahmad Caliri, Andrew W Tommasi, Stella
Since the early stages of the pandemic, hydroxychloroquine (HCQ), a widely used drug with good safety profile in clinic, has come to the forefront of research on drug repurposing for COVID-19 treatment/prevention. Despite the decades-long use of HCQ in the treatment of diseases, such as malaria and autoimmune disorders, the exact mechanisms of acti...
Ayer, Anita Fazakerley, Daniel J Suarna, Cacang Maghzal, Ghassan J Sheipouri, Diba Lee, Kevin J Bradley, Michelle C Fernández-Del-Rio, Lucía Tumanov, Sergey Kong, Stephanie My
...
Mitochondrial energy production and function rely on optimal concentrations of the essential redox-active lipid, coenzyme Q (CoQ). CoQ deficiency results in mitochondrial dysfunction associated with increased mitochondrial oxidative stress and a range of pathologies. What drives CoQ deficiency in many of these pathologies is unknown, just as there ...
Nasseef, Md Taufiq Ma, Weiya Singh, Jai Puneet Dozono, Naoki Lançon, Kevin Séguéla, Philippe Darcq, Emmanuel Ueda, Hiroshi Kieffer, Brigitte L
Published in
Brain imaging and behavior
Fibromyalgia (FM) is a generalized chronic pain condition whose pathophysiology is poorly understood, and both basic and translational research are needed to advance the field. Here we used the Sluka model to test whether FM-like pain in mice would produce detectable brain modifications using resting-state (rs) functional Magnetic Resonance Imaging...
Seninge, Lucas Anastopoulos, Ioannis Ding, Hongxu Stuart, Joshua
Deep learning architectures such as variational autoencoders have revolutionized the analysis of transcriptomics data. However, the latent space of these variational autoencoders offers little to no interpretability. To provide further biological insights, we introduce a novel sparse Variational Autoencoder architecture, VEGA (VAE Enhanced by Gene ...
