Sarto, Marcella Paula Mansano Lucas da Silva, Hevillyn Fernanda de Souza Fernandes, Nilma de Abreu, Ana Paula Zanusso Junior, Gerson de Ornelas Toledo, Max Jean
Published in
BMC Complementary Medicine and Therapies
Background Trypanosoma cruzi is the etiological agent of Chagas disease (CD) or American trypanosomiasis, an important public health problem in Latin America. Benznidazole (BZ), a drug available for its treatment, has limited efficacy and significant side effects. Essential oils (EOs) have demonstrated trypanocidal activity and may constitute a the...
Di Bella, Davide Ferreira, João P. S. Silva, Renee de Nazare O. Echem, Cinthya Milan, Aline Akamine, Eliana H. Carvalho, Maria H. Rodrigues, Stephen F.
Published in
Journal of Nanobiotechnology
Background Sepsis is an emergency medical condition that can lead to death and it is defined as a life-threatening organ dysfunction caused by immune dysregulation in response to an infection. It is considered the main killer in intensive care units. Sepsis associated-encephalopathy (SAE) is mostly caused by a sepsis-induced systemic inflammatory r...
Yang, Xiao-Yu Ma, Zhao-Liang Storm, Daniel R Cao, Hong Zhang, Yu-Qiu
Published in
World Journal of Psychiatry
BACKGROUND Major depressive disorder (MDD) is a highly disabling psychiatric syndrome associated with deficits of specific subpopulations of cortical GABAergic interneurons; however, the underlying molecular mechanism remains unknown. Type 3 adenylyl cyclase (ADCY3, AC3), which is important for neuronal excitability, has been implicated in MDD in a...
Sun, Bo Li, Fangda Lai, Song Zhang, Xu Wang, Hongxia Li, Yuan Wang, Wei Chen, Yuexin Liu, Bao Zheng, Yuehong
...
Published in
Acta Cirúrgica Brasileira
Purpose To investigate the relationship between atherosclerotic abdominal aortic aneurysm (AAA) and CXC chemokine receptor type 2 (CXCR2). Methods Mouse AAA model was established by embedding angiotensin-II pump (1000 ng/kg/min) in ApoE-/- mice. Mice were received SB225002, a selective CXCR2 antagonist, for treatment. Blood pressure was recorded, a...
Bandariyan, E. Mogheiseh, A. Ahmadi, A.
Published in
BMC Complementary Medicine and Therapies
BackgroundPolycystic ovary syndrome (PCOS) is one of the most prevalent endocrinopathies in women during the reproductive age. Herbal medicines are used increasingly alone or in supplement with chemical medicines for the treatment of different diseases and dysfunctions. This study was aimed to evaluate the effects of lutein and nettle (Urtica dioic...
Boccella, Serena Guida, Francesca Iannotta, Monica Iannotti, Fabio Arturo Infantino, Rosmara Ricciardi, Flavia Cristiano, Claudia Vitale, Rosa Maria Amodeo, Pietro Marabese, Ida
...
Published in
Molecular Brain
Neuropathic pain (NP) remains an untreatable disease due to the complex pathophysiology that involves the whole pain neuraxis including the forebrain. Sensory dysfunctions such as allodynia and hyperalgesia are only part of the symptoms associated with neuropathic pain that extend to memory and affectivity deficits. The development of multi-target ...
Qian, Fang-Yuan Guo, Yu-Dong Zu, Juan Zhang, Jin-Hua Zheng, Yi-Ming Abdoulaye, Idriss Ali Pan, Zhao-Hui Xie, Chun-Ming Gao, Han-Chao Zhang, Zhi-Jun
...
Published in
Acta Neuropathologica Communications
Mutations in the DNAJB6 gene have been identified as rare causes of myofibrillar myopathies. However, the underlying pathophysiologica mechanisms remain elusive. DNAJB6 has two known isoforms, including the nuclear isoform DNAJB6a and the cytoplasmic isoform DNAJB6b, which was thought to be the pathogenic isoform. Here, we report a novel recessive ...
Chen, Fading Swartzlander, Dan B. Ghosh, Anamitra Fryer, John D. Wang, Baiping Zheng, Hui
Published in
Molecular Neurodegeneration
BackgroundGenome-wide association studies have established clusterin (CLU) as a genetic modifier for late-onset Alzheimer’s disease (AD). Both protective and risk alleles have been identified which may be associated with its expression levels. However, the physiological function of clusterin in the central nervous system remains largely unknown.Met...
Hartig, Renée Wolf, David Schmeisser, Michael J. Kelsch, Wolfgang
Published in
Cell and Tissue Research
Olfaction supports a multitude of behaviors vital for social communication and interactions between conspecifics. Intact sensory processing is contingent upon proper circuit wiring. Disturbances in genetic factors controlling circuit assembly and synaptic wiring can lead to neurodevelopmental disorders, such as autism spectrum disorder (ASD), where...
Novielli-Kuntz, Nicole M. Press, Eric R. Barr, Kevin Prado, Marco A. M. Laird, Dale W.
Published in
Disease Models & Mechanisms
Summary: This study reveals that adult mice harboring a disease-linked Cx30 mutant exhibit morphological changes in the brain that result in behavioral abnormalities that are more pronounced in female mice.
