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Tellier, Michael Chalmers, Ronald
Published in
DNA repair
SETMAR is a fusion between a SET-domain methyltransferase gene and a mariner-family transposase gene, which is specific to anthropoid primates. However, the ancestral SET gene is present in all other mammals and birds. SETMAR is reported to be involved in transcriptional regulation and a diverse set of reactions related to DNA repair. Since the tra...
Jeyaratnam, Dinisha Cyril Baduin, Benjamin Stephan Hansen, Marcus Celik Hansen, Maria Jørgensen, Judit Meszaros Aggerholm, Anni Ommen, Hans Beier Hokland, Peter Nyvold, Charlotte Guldborg
Published in
Experimental Hematology
SETMAR, also known as Metnase, has previously been shown to suppress the formation of chromosomal translocation in mouse fibroblasts. Despite the fact that hematological malignancies are often characterized by chromosomal rearrangements no studies have hitherto investigated the expression pattern of the gene in these disorders. We hypothesized that...
Arnaoty, Ahmed Gouilleux-Gruart, Valérie Casteret, Sophie Pitard, Bruno Bigot, Yves Lecomte, Thierry
Published in
Molecular Genetics and Genomics
The molecular domestication of several DNA transposons that occurred during the evolution of the mammalian lineage, has led to the emergence of at least 43 genes, known as neogenes. To date, the limited availability of efficient commercial antibodies directed against most of their protein isoforms hampers investigation of their expression in vitro ...
ponder, jessica yoo, byong hoon abraham, adedoyin d. qun, li ashley, amanda k. amerin, courtney l. zhou, qiong reid, brian g. reigan, philip hromas, robert
...
Type IIα DNA topoisomerase (TopoIIα) is among the most important clinical drug targets for the treatment of cancer. Recently, the DNA repair protein Metnase was shown to enhance TopoIIα activity and increase resistance to TopoIIα poisons. Using in vitro DNA decatenation assays we show that neoamphimedine potently inhibits TopoIIα-dependent DNA deca...
Beck, Brian D. Lee, Sung S. Hromas, Robert Lee, Suk-Hee
Published in
Archives of Biochemistry and Biophysics
Metnase (also known as SETMAR) is a SET and transposase fusion protein in humans and plays a positive role in double-strand break (DSB) repair. While the SET domain possesses histone lysine methyltransferase activity, the transposase domain is responsible for 5′-terminal inverted repeat (TIR)-specific binding, DNA looping, and DNA cleavage activiti...
Shaheen, Montaser Williamson, Elizabeth Nickoloff, Jac Lee, Suk-Hee Hromas, Robert
Published in
Genetica
Metnase is a fusion gene comprising a SET histone methyl transferase domain and a transposase domain derived from the Mariner transposase. This fusion gene appeared first in anthropoid primates. Because of its biochemical activities, both histone (protein) methylase and endonuclease, we termed the protein Metnase (also called SETMAR). Metnase methy...
