Published in Journal of neurology
The aim of this review was to analyse the pathophysiology of axonal degeneration in Guillain-Barré syndrome (GBS) with emphasis on early stages (≤ 10 days after onset). An overview of experimental autoimmune neuritis (EAN) models is provided. Originally GBS and acute inflammatory demyelinating polyneuropathy were equated, presence of axonal degener...
Published in Annals of Medicine and Surgery
- The development of an efficient treatment in Covid-19 infection was a challenge, especially the corticosteroids. - The aim of this paper is to compare between two most used corticosteroids in the treatment of Covid 19 diseases: Dexamethasone and methylprednisolone - A significant reduction of oxygen requirement was noted in the second group of pa...
Published in World Journal of Critical Care Medicine
BACKGROUND Our understanding of the severe acute respiratory syndrome coronavirus 2 has evolved since the first reported cases in December 2019, and a greater emphasis has been placed on the hyper-inflammatory response in severely ill patients. The purpose of this study was to determine risk factors for mortality and the impact of anti-inflammatory...
Published in BMC Gastroenterology
Background There is rising utilization of immune checkpoint inhibitors (ICI) for a growing number of metastatic malignancies. While gastrointestinal side effects of ICI are common, isolated ICI-induced enteritis leading to small bowel hemorrhage is rare. Case presentation A 71-year-old man with a previously resected right colon adenocarcinoma on at...
Published in The American Journal of Case Reports
Patient: Male, 62-year-old Final Diagnosis: COVID-19 • periaortitis Symptoms: Abdominal pain • dry cough • fatigue • shortness of breath Medication: — Clinical Procedure: Mechanical ventilation Specialty: Critical Care Medicine Objective: Unusual clinical course Background: Periaortitis is an inflammatory condition that typically involves the infra...
Published in Indian journal of pediatrics
To assess the feasibility, effectiveness, and safety of pulse methylprednisolone in comparison with intramuscular adrenocorticotropic hormone (ACTH) therapy in children with West syndrome (WS). This open-label, pilot study with a parallel-group assignment included 44 recently diagnosed children with WS. Methylprednisolone therapy was given as intra...
Published in Internal and emergency medicine
Little evidence appears to exist for the use of anakinra, a recombinant interleukin-1 receptor antagonist, after non-response to treatment with corticosteroids alone or combined with tocilizumab in patients with severe COVID-19 pneumonia and moderate hyperinflammatory state. A retrospective observational cohort study was carried out involving 143 p...
Published in BMC Infectious Diseases
BackgroundAlthough almost a year has passed since the Coronavirus disease 2019 (COVID-19) outbreak and promising reports of vaccines have been presented, we still have a long way until these measures are available for all. Furthermore, the most appropriate corticosteroid and dose in the treatment of COVID-19 have remained uncertain. We conducted a ...
Published in World Journal of Clinical Cases
BACKGROUND Granulomatosis with polyangiitis is a necrotizing inflammation of small and medium-sized vessels accompanied by formation of granuloma, involvement of primary granulomatous upper and lower respiratory tracts, glomerulonephritis, and vasculitis of small vessels. CASE SUMMARY Herein, we described a case of a 52-year-old man admitted with p...
Published in The Journal of infection
