Solanich, X. Antolí, A. Padullés, N. Fanlo-Maresma, M. Iriarte, A. Mitjavila, F. Capdevila, O. Molina, M. Sabater, J. Bas, J.
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Published in
Contemporary Clinical Trials Communications
Introduction Some COVID-19 patients evolve to severe lung injury and systemic hyperinflammatory syndrome triggered by both the coronavirus infection and the subsequent host-immune response. Accordingly, the use of immunomodulatory agents has been suggested but still remains controversial. Our working hypothesis is that methylprednisolone pulses and...
Les Bujanda, Iñigo Loureiro-Amigo, Jose Bastons, Ferran Capdevila Guerra, Iñaki Elejalde Sánchez, Javier Anniccherico Murgadella-Sancho, Anna Rey, Ruth García López, Julián Librero Álvarez, Julio Sánchez
Published in
Trials
ObjectivesThe aim of this study is to assess the effectiveness and safety of glucocorticoid infusion pulse therapy to improve the clinical outcomes of patients with COVID-19 pneumonia with elevated inflammatory biomarkers.Trial designA parallel-group quadruple-blind (participant, intervention provider, outcome assessor and data manager), randomised...
Aomar-Millán, Ismael Francisco Salvatierra, Juan Torres-Parejo, Úrsula Faro-Miguez, Naya Callejas-Rubio, José Luis Ceballos-Torres, Ángel Cruces-Moreno, María Teresa Gómez-Jiménez, Francisco Javier Hernández-Quero, José Anguita-Santos, Francisco
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Published in
Internal and Emergency Medicine
Introduction Little evidence appears to exist for the use of anakinra, a recombinant interleukin-1 receptor antagonist, after non-response to treatment with corticosteroids alone or combined with tocilizumab in patients with severe COVID-19 pneumonia and moderate hyperinflammatory state. Patients and Methods A retrospective observational cohort stu...
Kosaka, Makoto Yamazaki, Yoshitaka Maruno, Takashi Sakaguchi, Koji Sawaki, Shoji
Published in
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
The effect of systemic corticosteroids on clinical outcomes in patients with coronavirus disease 2019 (COVID-19) remains controversial. While the use of corticosteroids raises concerns regarding delayed viral clearance, secondary infections, and long-term complications that can lead to increased mortality, corticosteroids have the potential to redu...
Takami, Toshihiro Shimokawa, Nobuyuki Parthiban, Jutty Zileli, Mehmet Ali, Sheena
Published in
Neurospine
This is a review article examining the pharmacologic and regenerative cell therapy for spinal cord injury. A literature search during last 10 years were conducted using key words. Case reports, experimental (nonhuman) studies, papers other than English language were excluded. Up-to-date information on the pharmacologic and regenerative cell therapy...
Aoki, Shuntaro Yasui, Masato Tajirika, Hironao Terao, Hideyuki Funahashi, Makoto Ohta, Junichi
Published in
Case Reports in Oncology
An 85-year-old female was admitted to our hospital for left ureteral cancer and para-aortic lymph node metastasis. To control hematuria, a laparoscopic retroperitoneal nephroureterectomy was performed, and papillary urothelial carcinoma (pT3b) was found. To treat para-aortic lymph node metastasis, she received chemotherapy with gemcitabine and neda...
Jia, Lin Xue, Ran Zhu, Yueke Zhao, Juan Li, Juan He, Wei-Ping Wang, Xiao-Mei Duan, Zhong-Hui Ren, Mei-Xin Liu, Hai-Xia
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Published in
BMC Medicine
BackgroundHepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a severe condition with high mortality due to lack of efficient therapy. Until now, the use of methylprednisolone (MP) in HBV-ACLF is still controversial. We aimed to evaluate the efficacy and safety of MP in HBV-ACLF.MethodsTotally 171 HBV-ACLF patients from three med...
Zhu, Hong-Ming Li, Yan Li, Bang-Yi Yang, Shuang Peng, Ding Yang, Xiaojiao Sun, Xue-Lian Zhang, Mei
Published in
World Journal of Clinical Cases
BACKGROUND The coronavirus disease 2019 (COVID-19) outbreak has brought great challenges to public health. Aggravation of COVID-19 is closely related to the secondary systemic inflammatory response. Glucocorticoids are used to control severe diseases caused by the cytokine storm, owing to their anti-inflammatory effects. However, glucocorticoids ar...
Fatima, Syeda Arzinda Asif, Mohsin Khan, Khurshid A Siddique, Nasir Khan, Aijaz Zeeshan
Published in
Annals of medicine and surgery (2012)
The first case of Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were diagnosed in Wuhan, China in 2019. In the first half of 2020 this disease has already converted into a global pandemic. Various treatment options were being tried all over the world. Some studies showed beneficial effects of corticosteroids in covid 1...
Wu, Chaomin Hou, Dongni Du, Chunling Cai, Yanping Zheng, Junhua Xu, Jie Chen, Xiaoyan Chen, Cuicui Hu, Xianglin Zhang, Yuye
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Published in
Critical Care
BackgroundThe impact of corticosteroid therapy on outcomes of patients with coronavirus disease 2019 (COVID-19) is highly controversial. We aimed to compare the risk of death between COVID-19-related ARDS patients with corticosteroid treatment and those without.MethodsIn this single-center retrospective observational study, patients with ARDS cause...
