Cicekdal, M B Kazan, B T Tuna, B G Ozorhan, U Ekici, I D Zhu, F Suakar, O Kuskucu, A Bayrak, O F Arcaro, K
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Published in
The British journal of nutrition
The role of adiponectin and leptin signalling pathways has been suggested to play important roles in the protective effects of energy restriction (ER) on mammary tumour (MT) development. To study the effects of ER on the methylation levels in adiponectin receptor 1 (AdipoR1) and leptin receptor overlapping transcript (Leprot) genes using the pyrose...
Luo, Dan Yang, QingLing Wang, HaiBo Tan, Mao Zou, YanLei Liu, Jian
Published in
BMC Medical Genomics
BackgroundThe role(s) of epigenetic reprogramming in gastric cancer (GC) remain obscure. This study was designed to identify methylated gene markers with prognostic potential for GC.MethodsFive datasets containing gene expression and methylation profiles from GC samples were collected from the GEO database, and subjected to meta-analysis. All five ...
Berglund, Anders E Putney, Ryan M Creed, Jordan H Aden-Buie, Garrick Gerke, Travis A Rounbehler, Robert J
Published in
Methods in molecular biology (Clifton, N.J.)
Bioinformatic scientists are often asked to do widespread analyses of publicly available datasets in order to identify genetic alterations in cancer for genes of interest; therefore, we sought to create a set of tools to conduct common statistical analyses of The Cancer Genome Atlas (TCGA) data. These tools have been developed in response to reques...
Desai Boström, Adrian
Epigenetics has evolved into a key research focus in the field of psychiatry. DNA methylation is the most researched epigenetic mechanism. In paper I-III, 130 and 93 adolescents were randomly recruited at two separate intervals. Subjects were evaluated by web-based diagnostic interviews using the Development and Well-Being Assessment (DAWBA), provi...
Shi, Hao-Hong Liu, Hai-E Luo, Xing-Jing
Published in
BMB Reports
The N-myc downstream regulated gene (NDRG) family members are dysregulated in several tumors. Functionally, NDRGs play an important role in the malignant progression of cancer cells. However, little is known about the potential implications of NDRG4 in pancreatic ductal adenocarcinoma (PDAC). The aim of the current study was to elucidate the expres...
Anani, Maha Nobuhisa, Ikuo Taga, Tetsuya
Published in
Journal of Cancer Prevention
A transcription factor Sry-related high mobility group box (Sox) 17 is involved in developmental processes including spermatogenesis, cardiovascular system, endoderm formation, and so on. In this article, we firstly review the studies on the relation between the Sox17 expression and tumor malignancy. Although Sox17 positively promotes various tissu...
Hosseini, Arezoo Babaloo, Zohreh Gharibi, Tohid Shomali, Navid Marofi, Faroogh Hashemi, Vida Ayromlou, Hormoz Asadi, Milad Rahmani, Shima Noorolyai, Saeed
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Published in
BMC Research Notes
ObjectivesImmunological tolerance is mediated by CD4+CD25+ regulatory T (Treg) cells. Studies have shown that thymic and peripheral generations of Treg cells depend on the CD28 signaling pathway. T helper 17 (Th17) cells are involved in the pathophysiology of various inflammatory diseases. Cytokines, such as interleukin (IL)-6 and TGF-β, regulate t...
Hou, Mingming Guo, Xiaohui Chen, Yu Cong, Lidan Pan, Changwu
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Soft-tissue sarcomas are a group of heterogeneous and rare mesenchymal tumors with aggressive behavior. We aimed to identify the molecular signatures of N6-methyladenosine (m6A) methylation regulators associated with patient prognosis using The Cancer Genome Atlas (TCGA) database. Material/Methods To evaluate the role of m6A in soft-tiss...
Jahnke, Johanna R Terán, Enrique Murgueitio, Francisca Cabrera, Holger Thompson, Amanda L
Published in
Placenta
Prenatal stress is known to influence fetal hypothalamic-pituitary-adrenal axis (HPA axis) development. Placental 11β-hydroxysteroid dehydrogenase type 2 (HSD11B2) is a central gene in this pathway, but little is known about what influences its functioning. We assess how maternal distress influences HSD11B2 functioning, and how HSD11B2 in turn, is ...
Ali, Asad Amanat Cui, Xiaoying Pertile, Renata Aparecida Nedel Li, Xiang Medley, Gregory Alexander, Suzanne Adele Whitehouse, Andrew J. O. McGrath, John Joseph Eyles, Darryl Walter
Published in
Molecular Autism
BackgroundAutism spectrum disorder (ASD) is a group of neurodevelopmental disorders which are more common in males. The ‘prenatal sex steroid’ hypothesis links excessive sex-steroid exposure during foetal life with the behavioural differences observed in ASD. However, the reason why sex steroid exposure may be excessive remains unclear. Epidemiolog...
