Khokhar, Manoj Roy, Dipayan Bajpai, Nitin Kumar Bohra, Gopal Krishna Yadav, Dharamveer Sharma, Praveen Purohit, Purvi
Published in
Archives of physiology and biochemistry
Metformin is commonly used as an oral hypoglycaemic agent in type 2 diabetes mellitus (T2DM). MicroRNA-21 is widely studied in diabetic and diabetic nephropathy (DN) patients. Matrix metalloproteinase-9 (MMP9) is involved in extracellular matrix degradation and tissue repair processes. However, the effect of metformin administration on hsa-miR-21-5...
Gopar-Cuevas, Yareth Saucedo-Cardenas, Odila Loera-Arias, Maria J Montes-de-Oca-Luna, Roberto Rodriguez-Rocha, Humberto Garcia-Garcia, Aracely
Published in
Molecular neurobiology
Since the number of aged people will increase in the next years, neurodegenerative diseases, including Parkinson's Disease (PD), will also rise. Recently, we demonstrated that autophagy stimulation with rapamycin decreases dopaminergic neuronal death mediated by oxidative stress in the paraquat (PQ)-induced PD model. Assessing the neurotherapeutic ...
Ishizaki, Atsushi Ozawa, Kazutaka Kataoka, Hiroyuki
Published in
Journal of chromatography. A
Contamination of active pharmaceutical ingredients (APIs) and pharmaceutical preparations with carcinogenic N-nitrosamines has led to recalls of these products and supply shortages to patients. The present study describes the development of a highly sensitive method for simultaneous analysis of seven N-nitrosamines using on-line in-tube solid-phase...
Salminen, Antero
Published in
Biogerontology
Disruption of the extracellular matrix (ECM) and an accumulation of fibrotic lesions within tissues are two of the distinctive hallmarks of the aging process. Tissue fibroblasts are mesenchymal cells which display an impressive plasticity in the regulation of ECM integrity and thus on tissue homeostasis. Single-cell transcriptome studies have revea...
Kuno, Hideaki Fujimaru, Takuya Kadota, Nozomi Konishi, Kasumi Sekiguchi, Momoko Watanabe, Kimio Ito, Yugo Nagahama, Masahiko Taki, Fumika Hifumi, Toru
...
Published in
CEN case reports
Metformin-associated lactic acidosis is a well-known metformin treatment complication; however, the development of euglycemic diabetic ketoacidosis (euDKA) has rarely been reported. Here we report a case of lactic acidosis and euDKA after metformin overdose. A 57-year-old female patient was transferred to our hospital with severe metabolic acidosis...
Cheki, Mohsen Mostafaei, Shayan Hanafi, Mohammad Ghasem Farasat, Maryam Talaiezadeh, Abdolhassan Ghasemi, Mohammad Sadegh Modava, Mohammad Abdollahi, Hamid
Published in
Japanese journal of radiology
Metformin is considered as radiation modulator in both tumors and healthy tissues. Radiomics has the potential to decode biological mechanisms of radiotherapy response. The aim of this study was to apply radiomics analysis in metformin-induced radiosensitivity and finding radioproteomics associations of computed tomography (CT) imaging features and...
Xu, Yu Cai, Hongke Xiong, Yuanfeng Tang, Li Li, Longjiang Zhang, Li Shen, Yi Yang, Yongqiang Lin, Ling Huang, Jiayi
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Published in
Journal of chemotherapy (Florence, Italy)
Breast cancer is malignant tumours in women. A large amount of data analysis shows that Metformin has been shown to play a significance role in reducing the risk of breast cancer, but the mechanism remains unclear. The hippo signalling pathway can be involved in the formation, metastasis and recurrence of breast cancer. When YAP/TAZ is activated, c...
Moens de Hase, Emilie Neyrinck, Audrey M Rodriguez, Julie Cnop, Miriam Paquot, Nicolas Thissen, Jean-Paul Xu, Yining Beloqui, Ana Bindels, Laure B Delzenne, Nathalie M
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Published in
Diabetologia
We aimed to investigate the association between the abundance of Dysosmobacter welbionis, a commensal gut bacterium, and metabolic health in human participants with obesity and diabetes, and the influence of metformin treatment and prebiotic intervention. Metabolic variables were assessed and faecal samples were collected from 106 participants in a...
Proietti, Giacomo Burico, Michela Quintiero, Claudio Marzio Giovagnoni, Emiliano Mercati, Valentino Gianni, Mattia Mattoli, Luisa
Published in
Journal of mass spectrometry : JMS
Drugs are indispensable products with incontrovertible benefits to human health and lifestyle. However, due to their overuse and improper disposal, unwanted residues of active pharmaceutical ingredients (APIs) have been found in different compartments of the environment and now are considered as contaminants of emerging concern (CECs). Therefore, t...
Chen, Jiaqi Wang, Lu Tian, Geng G Wang, Xiang Li, Xiaoyong Wu, Ji
Published in
Stem cell reviews and reports
Female germline stem cells (FGSCs) are adult stem cells that can both self-renew and differentiate into mature oocytes. Although small-molecule compounds are capable of regulating the development of FGSCs, the effects and mechanisms of action of metformin, a commonly used drug for diabetes, on FGSCs are largely unknown. Here, we found that metformi...
