Francis, Jasmine H Canestraro, Julia Abramson, David H Barker, Christopher A Shoushtari, Alexander N
Published in
American journal of ophthalmology case reports
Cutaneous melanoma metastatic to the vitreous/retina is rare but increasingly common. Due to the potential of recurrent disease with current treatment options and the propensity for these eyes to develop neovascularization, these eyes can pose a treatment challenge and novel management strategies are needed. This case series explores the use of com...
Googe, Paul B Theocharis, Stamatios Pergaris, Alexandros Li, Haocheng Yan, Yibing McKenna, Edward F Jr Moschos, Stergios J
Published in
Current problems in cancer
We conducted a retrospective tumor tissue analysis as part of the BRIM3 trial to evaluate the theragnostic significance of tumor-infiltrating lymphocytes (TILs) and melanoma cell proliferation. Using manual semi-quantitative analyses, we assessed the density of TILs by pathology review of tissue sections stained with hematoxylin and eosin (H&E TIL ...
Kumar, Priyanka Brazel, Danielle DeRogatis, Julia Valerin, Jennifer B. Goldstein Whiteson, Katrine Chow, Warren A. Tinoco, Roberto Moyers, Justin T.
Published in
Cancer Metastasis Reviews
Therapy for cutaneous melanoma, the deadliest of the skin cancers, is inextricably linked to the immune system. Once thought impossible, cures for metastatic melanoma with immune checkpoint inhibitors have been developed within the last decade and now occur regularly in the clinic. Unfortunately, half of tumors do not respond to checkpoint inhibito...
Kumar, Priyanka Brazel, Danielle DeRogatis, Julia Valerin, Jennifer B Goldstein Whiteson, Katrine Chow, Warren A Tinoco, Roberto Moyers, Justin T
Therapy for cutaneous melanoma, the deadliest of the skin cancers, is inextricably linked to the immune system. Once thought impossible, cures for metastatic melanoma with immune checkpoint inhibitors have been developed within the last decade and now occur regularly in the clinic. Unfortunately, half of tumors do not respond to checkpoint inhibito...
Thivat, Emilie Rouanet, Jacques Auzeloux, Philippe Sas, Nicolas Jouberton, Elodie Levesque, Sophie Billoux, Tommy Mansard, Sandrine Molnar, Ioana Chanchou, Marion
...
Published in
BMC cancer
Benzamide-based radioligands targeting melanin were first developed for imaging melanoma and then for therapeutic purpose with targeted radionuclide therapy (TRT). [131I]ICF01012 presents a highly favorable pharmacokinetics profile in vivo for therapy. Tumour growth reduction and increase survival have been established in preclinical models of mela...
Guida, Michele Bartolomeo, Nicola Quaresmini, Davide Quaglino, Pietro Madonna, Gabriele Pigozzo, Jacopo Di Giacomo, Anna Maria Minisini, Alessandro Marco Tucci, Marco Spagnolo, Francesco
...
Published in
Journal of Translational Medicine
Background To evaluate the capability of basal and one-month differed white blood cells (WBC), neutrophil, lymphocyte and platelet values and their ratios (neutrophils-to-lymphocytes ratio, NLR, and platelets-to-lymphocytes ratio, PLR) in predicting the response to i mmune checkpoint inhibitors (ICI) in metastatic melanoma (MM). Methods We performe...
Kharroubi, Hussein Osman, Bassam Kakati, Rasha T. Korman, Rawan Khalife, Mohamad Jawad
Published in
International Journal of Surgery Case Reports
• Malignant melanoma has predilection to metastasize to the small bowel. • A metastatic melanoma lesion may act as a lead point causing intussusception despite immunotherapy treatment. • There is no consensus on management of small bowel intussusception caused by a metastatic melanoma. • Reduction and resection of the lead point in a small surgical...
Eshtiaghi, Arshia Nguyen, Michael T B Micieli, Jonathan A
Published in
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Koppes, S A Schrader, A M R Jansen, A M L Rijken, J A Kamphuis, A M Blokx, W A M
Published in
Virchows Archiv : an international journal of pathology
Mucosal melanomas are rare and only a small portion bear BRAF mutations while cutaneous melanomas have a much higher prevalence and often harbor BRAF mutations. We present two cases in which, after a malignant melanocytic mucosal lesion with a BRAF mutation was found, the primary cutaneous source was identified and clonality confirmed between the l...
Patel, Ayushi Carr, Michael J Sun, James Zager, Jonathan S
Published in
Clinical & experimental metastasis
Management of in-transit melanoma encompasses a variety of possible treatment pathways and modalities. Depending on the location of disease, number of lesions, burden of disease and patient preference and characteristics, some treatments may be more beneficial than others. After full body radiographic staging is performed to rule out metastatic dis...
