Corroyer-Dulmont, Aurélien Valable, Samuel Fantin, Jade Chatre, Laurent Toutain, Jérôme Teulier, Sylvain Bazille, Céline Letissier, Elise Levallet, Jérôme Divoux, Didier
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Published in
Scientific Reports
Lung cancer patients frequently develop brain metastases (BM). Despite aggressive treatment including neurosurgery and external-radiotherapy, overall survival remains poor. There is a pressing need to further characterize factors in the microenvironment of BM that may confer resistance to radiotherapy (RT), such as hypoxia. Here, hypoxia was first ...
Takenaga, Keizo Koshikawa, Nobuko Nagase, Hiroki
Published in
BMC Molecular and Cell Biology
Background Mitochondrial DNA (mtDNA) carrying certain pathogenic mutations or single nucleotide variants (SNVs) enhances the invasion and metastasis of tumor cells, and some of these mutations are homoplasmic in tumor cells and even in tumor tissues. On the other hand, intercellular transfer of mitochondria and cellular components via extracellular...
Bruckschen, F. Gerharz, C. D. Sagir, A.
Published in
Journal of Medical Case Reports
Introduction Renal cell carcinoma is the third most common malignant tumor in the urogenital tract. An estimated 25% of renal cell carcinomas are in stage IV when diagnosed. The 5-year-survival with stage IV is about 20%. Late metastases are found after an extended disease-free interval up to 20 years after primary nephrectomy. Case presentation He...
Escala-Garcia, Maria Canisius, Sander Keeman, Renske Beesley, Jonathan Anton-Culver, Hoda Arndt, Volker Augustinsson, Annelie Becher, Heiko Beckmann, Matthias W. Behrens, Sabine
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Published in
Scientific Reports
Breast cancer metastasis accounts for most of the deaths from breast cancer. Identification of germline variants associated with survival in aggressive types of breast cancer may inform understanding of breast cancer progression and assist treatment. In this analysis, we studied the associations between germline variants and breast cancer survival ...
Kim, Kangsan Zhou, Qinbo Christie, Alana Stevens, Christina Ma, Yuanqing Onabolu, Oreoluwa Chintalapati, Suneetha Mckenzie, Tiffani Tcheuyap, Vanina Toffessi Woolford, Layton
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Published in
Nature Communications
Tumour thrombi (TT) are intravascular extensions of renal cell carcinomas (RCC) which often lead to distant metastases. Here the authors examine the determinants of vascular invasion and metastasis in a unique cohort of RCC patients with TT using multi-region genomics and in vivo models.
Sassi, I. Ghalleb, M. Chemlali, M. Mbarek, M. Charfi, L. Chargui, R. Rahal, K.
Published in
Journal of Medical Case Reports
Introduction Metastases to the female genital tract from extragenital primary tumors are unusual. We report a rare case of uterine cervix metastasis from colon adenocarcinoma and discuss diagnostic and therapeutic issues. Case report We report a case of a 38-year-old North African Caucasian woman treated for a non-metastatic colon adenocarcinoma. S...
Hirsch, Theo Z Pilet, Jill Morcrette, Guillaume Roehrig, Amélie Monteiro, Benedict J E Molina, Laura Bayard, Quentin Trépo, Eric Meunier, Léa Caruso, Stefano
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Published in
Cancer discovery
Pediatric liver cancers (PLC) comprise diverse diseases affecting infants, children, and adolescents. Despite overall good prognosis, PLCs display heterogeneous response to chemotherapy. Integrated genomic analysis of 126 pediatric liver tumors showed a continuum of driver mechanisms associated with patient age, including new targetable oncogenes. ...
Stokkel, Laura E Stokkel, Marcel P M Donswijk, Maarten L Lahaye, Max J Bekers, Elise M van Rhijn, Bas W G Mertens, Laura S
Published in
Clinical genitourinary cancer
Urachal carcinoma (UrC) is a rare malignancy that often presents at an advanced stage with metastases in up to a quarter of patients. There is no consensus on the optimal form of staging for patients with UrC. In the present study, we evaluated the diagnostic value of 18F-fluorodeoxyglucose-positron emitted tomography/computed tomography (FDG-PET/C...
Lefrère, Hanne; Floris, Giuseppe; Schmidt, Marjanka K; Neven, Patrick; 37755; Warner, Ellen; Cardonick, Elyce; Peccatori, Fedro Alessandro; Loibl, Sibylle; Maggen, Charlotte; De Mulder, Hanne;
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Postpartum breast cancer (PPBC) - which according to new data, can extend to 5-10 years after the birth - are estimated to represent 35-55% of all cases of breast cancer in women younger than 45 years. Increasing clinical evidence indicates that PPBC represents a high-risk form of breast cancer in young women with an approximately 2-fold increased ...
Huang, Chengmei Ou, Ruizhang Chen, Xiaoning Zhang, Yaxin Li, Jiexi Liang, Yihao Zhu, Xiaohui Liu, Lei Li, Mingzhou Lin, Dagui
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Published in
Journal of Experimental & Clinical Cancer Research : CR
Background Tumor-associated macrophages (TAMs) are key regulators of the complex interplay between cancer and the immune microenvironment. Tumor cell-derived spondin 2 (SPON2) is an extracellular matrix glycoprotein that has complicated roles in recruitment of macrophages and neutrophils during inflammation. Overexpression of SPON2 has been shown t...
