Thompson, Cai Hugo McCartney, Mitchell M Roubtsova, Tatiana V Kasuga, Takao Ebeler, Susan E Davis, Cristina Bostock, Richard M
Published in
Phytopathology
Phytophthora ramorum is an invasive, broad host-range pathogen that causes ramorum blight and sudden oak death in forest landscapes of western North America. In commercial nurseries, asymptomatic infections of nursery stock by P. ramorum and other Phytophthora species create unacceptable risk, and complicate inspection and certification programs de...
Yang, Guiling Wang, Yanhua Li, Jian Wang, Dou Bao, Zhiwei Wang, Qiang Jin, Yuanxiang
Published in
Journal of hazardous materials
Chlorothalonil (CTL), carbendazim (CBZ), and prochloraz (PCZ) are fungicides widely used in many countries. The use of these fungicides raises concerns because they are often applied together or used in the same agricultural area. However, the toxicity of these fungicides or mixtures, especially to aquatic organisms, has received limited attention....
Wei, Feifei Ito, Kengo Sakata, Kenji Asakura, Taiga Date, Yasuhiro Kikuchi, Jun
Published in
Scientific Reports
Functional diversity rather than species richness is critical for the understanding of ecological patterns and processes. This study aimed to develop novel integrated analytical strategies for the functional characterization of fish diversity based on the quantification, prediction and integration of the chemical and physical features in fish muscl...
Andraos, Stephanie Lange, Katherine Clifford, Susan A. Jones, Beatrix Thorstensen, Eric B. Wake, Melissa Burgner, David P. Saffery, Richard O’Sullivan, Justin M.
Published in
Scientific Reports
Amino acid (AA) concentrations are influenced by both exogenous (e.g. diet, lifestyle) and endogenous factors (e.g. genetic, transcriptomic, epigenetic, and metabolomic). Fasting plasma AA profiles in adulthood are predictive of diabetes risk over periods of up to 12 years. Data on AA profiles in cross-generational cohorts, including individuals fr...
Koyanagi, Iyo Sonomura, Kazuhiro Naoi, Toshie Ohnishi, Takaaki Kaneko, Naoko Sawamoto, Kazunobu Sato, Taka-Aki Sakaguchi, Masanori
Published in
Molecular Brain
Metabolites underlying brain function and pathology are not as well understood as genes. Here, we applied a novel metabolomics approach to further understand the mechanisms of memory processing in sleep. As hippocampal dentate gyrus neurons are known to consolidate contextual fear memory, we analyzed real-time changes in metabolites in the dentate ...
Hepokoski, Mark Wang, Jing Li, Kefeng Li, Ying Gupta, Purva Mai, Tina Moshensky, Alex Alotaibi, Mona Crotty Alexander, Laura E Malhotra, Atul
...
Published in
American journal of physiology. Lung cellular and molecular physiology
Acute respiratory distress syndrome (ARDS) is a common cause of mortality in patients with acute kidney injury (AKI). Inflammatory crosstalk from the kidney to the lung has been shown to contribute to lung injury after AKI, but anti-inflammatory therapies have not been proven beneficial in human studies. Recently, AKI was shown to alter mitochondri...
Jiang, Lingyan Wang, Peisheng Song, Xiaorui Zhang, Huan Ma, Shuangshuang Wang, Jingting Li, Wanwu Lv, Runxia Liu, Xiaoqian Ma, Shuai
...
Published in
Nature Communications
Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here, Jiang et al. show that infected macrophages exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates that promote intracellular replication and virulence of S. Typhimurium.
Karagiannidis, Efstratios Sofidis, Georgios Papazoglou, Andreas S. Deda, Olga Panteris, Eleftherios Moysidis, Dimitrios V. Stalikas, Nikolaos Kartas, Anastasios Papadopoulos, Anastasios Stefanopoulos, Leandros
...
Published in
BMC Cardiovascular Disorders
BackgroundCoronary artery disease (CAD) remains one of the leading causes of mortality and morbidity worldwide. As oxygen and nutrient supply to the myocardium significantly decrease during ischemic periods, important changes occur regarding myocardial intermediary energy metabolism. Metabolomics is an emerging field in systems biology, which quant...
Caballero, Francisco Félix Struijk, Ellen A. Lana, Alberto Buño, Antonio Rodríguez-Artalejo, Fernando Lopez-Garcia, Esther
Published in
Scientific Reports
Elevated concentrations of acylcarnitines have been associated with higher risk of obesity, type 2 diabetes and cardiovascular disease. The aim of the present study was to assess the association between L-carnitine and acylcarnitine profiles, and 2-year risk of incident lower-extremity functional impairment (LEFI). This case–control study is nested...
Matsuo, Kazuya Hosoda, Kohkichi Tanaka, Jun Yamamoto, Yusuke Imahori, Taichiro Nakai, Tomoaki Irino, Yasuhiro Shinohara, Masakazu Sasayama, Takashi Kohmura, Eiji
...
Published in
BMC Neuroscience
BackgroundWe previously reported that heat shock protein 27 (HSP27) phosphorylation plays an important role in the activation of glucose-6-phosphate dehydrogenase (G6PD), resulting in the upregulation of the pentose phosphate pathway and antioxidant effects against cerebral ischemia–reperfusion injury. The present study investigated the effect of g...
