Dabaj, Ivana Ferey, Justine Marguet, Florent Gilard, Vianney Basset, Carole Bahri, Youssef Brehin, Anne-Claire Vanhulle, Catherine Leturcq, France Marret, Stéphane
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Published in
Scientific Reports
Duchenne muscular dystrophy (DMD) is a common and severe X-linked myopathy, characterized by muscle degeneration due to altered or absent dystrophin. DMD has no effective cure, and the underlying molecular mechanisms remain incompletely understood. The aim of this study is to investigate the metabolic changes in DMD using mass spectrometry-based im...
Liu, Shu Zhang, Xiaomeng Hu, Chunmei Wang, Yingxue Xu, Chunling
Published in
Oncology reports
Following the publication of this article, an interested reader drew to the authors' attention that some western blotting data bands had apparently been duplicated in Fig. 4D. The authors have re‑examined their original data, and realized that this figure was assembled incorrectly. The corrected version of Fig. 4 is shown below. The authors sincere...
Cerrato, Andrea Citti, Cinzia Cannazza, Giuseppe Capriotti, Anna Laura Cavaliere, Chiara Grassi, Giampaolo Marini, Federico Montone, Carmela Maria Paris, Roberta Piovesana, Susy
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Published in
Talanta
Cannabis sativa is traditionally classified according to five chemotypes based on the concentration of the main phytocannabinoids tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabigerol (CBG). However, cannabis chemovars and varieties very often present similar concentrations of such phytocannabinoids but different chemical profiles, which ...
Wang, Wenyu He, Zhuoru Kong, Yu Liu, Zhongqiu Gong, Lingzhi
Published in
Clinica chimica acta; international journal of clinical chemistry
Lack of efficient noninvasive biomarkers for differentiating prostate cancer (PCa) and benign prostate hyperplasia (BPH) is a serious concern for men's health worldwide. In this study, we aimed to improve the diagnostic capability of the existing noninvasive biomarkers for PCa. GC-MS-based untargeted metabolomics was employed to analyze plasma samp...
Póvoa, Valquíria Mariane Oliveira Delafiori, Jeany Dias-Audibert, Flávia Luísa de Oliveira, Arthur Noin Lopes, Ana Beatriz Pascoal de Paula, Erich Vinícius Pagnano, Katia Borgia Barbosa Catharino, Rodrigo Ramos
Published in
Medical Oncology
AbstractThe Estudo de Descontinuação de Imatinibe após Pioglitazona (EDI-PIO) is a single-center, longitudinal, prospective, phase 2, non-randomized, open, clinical trial (NCT02852486, August 2, 2016 retrospectively registered) for the discontinuation of imatinib after concomitant use of pioglitazone, being the first of its kind in a Brazilian popu...
Mao, Hongmei Wang, Wenjun Shi, Lili Chen, Chen Han, Chao Zhao, Jinpeng Zhuo, Qin Shen, Shi Li, Yan Huo, Junsheng
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Published in
Nutrition & Metabolism
BackgroundData from the 2010–2012 Chinese National Nutrition and Health Survey showed that the vast majority of postmenopausal women in China had dual deficiencies in calcium and estrogen.ObjectiveThis study aimed to clarify whether calcium supplementation alleviated bone loss caused by calcium restriction combined with estrogen deficiency in rats....
Shi, Yanyan Chen, Zhen Li, Yixin Cao, Xingyu Yang, Lijie Xu, Yiyuan Li, Zhipeng He, Ning
Published in
Biotechnology for Biofuels
BackgroundAs a potential source of polyunsaturated fatty acids (PUFA), Schizochytrium sp. has been widely used in industry for PUFA production. Polyketide synthase (PKS) cluster is supposed to be the primary way of PUFA synthesis in Schizochytrium sp. As one of three open reading frames (ORF) in the PKS cluster, ORFC plays an essential role in fatt...
Wang, Biting Wu, Zengrui Li, Weihua Liu, Guixia Tang, Yun
Published in
Chinese Medicine
BackgroundThe traditional Chinese medicine Huangqi decoction (HQD) consists of Radix Astragali and Radix Glycyrrhizae in a ratio of 6: 1, which has been used for the treatment of liver fibrosis. In this study, we tried to elucidate its action of mechanism (MoA) via a combination of metabolomics data, network pharmacology and molecular docking metho...
Gallego-Paüls, Marta Hernández-Ferrer, Carles Bustamante, Mariona Basagaña, Xavier Barrera-Gómez, Jose Lau, Chung-Ho E. Siskos, Alexandros P. Vives-Usano, Marta Ruiz-Arenas, Carlos Wright, John
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Published in
BMC Medicine
BackgroundMultiple omics technologies are increasingly applied to detect early, subtle molecular responses to environmental stressors for future disease risk prevention. However, there is an urgent need for further evaluation of stability and variability of omics profiles in healthy individuals, especially during childhood.MethodsWe aimed to estima...
Miallot, Richard Galland, Franck Millet, Virginie Blay, Jean-Yves Naquet, Philippe
Published in
Journal of Hematology & Oncology
Metabolic rewiring offers novel therapeutic opportunities in cancer. Until recently, there was scant information regarding soft tissue sarcomas, due to their heterogeneous tissue origin, histological definition and underlying genetic history. Novel large-scale genomic and metabolomics approaches are now helping stratify their physiopathology. In th...
