Brochado-Kith, Oscar Rava, Marta Berenguer, Juan González-García, Juan Rojo, David Díez, Cristina Hontañon, Victor Virseda-Berdices, Ana Ibañez-Samaniego, Luis Llop-Herrera, Elba
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Published in
Journal of infection and public health
Altered bacterial translocation is associated with changes in hepatic function and the progression from compensated to decompensated cirrhosis. Child-Turcotte-Pugh (CTP) score is an essential indicator of liver severity. Thus, we aimed to study differences in the blood microbiome together with metabolome profile between HCV-infected patients with C...
Suthar, Himal Tanghal, Roselyn B Chatzi, Lida Goodrich, Jesse A Morello-Frosch, Rachel Aung, Max
Purpose of reviewDepression during the perinatal or antenatal period affects at least 1 in 10 women worldwide, with long term health implications for the mother and child. Concurrently, there is increasing evidence associating maternal exposure to per- and poly-fluoroalkyl substances (PFAS) to adverse pregnancy outcomes. We reviewed the body of evi...
Zhang, Bing Magnaye, Kevin Stryker, Emily Moltzau-Anderson, Jacqueline Porsche, Cara Hertz, Sandra McCauley, Kathryn Smith, Byron Zydek, Martin Pollard, Katherine
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Fecal microbial transplantation (FMT) offers promise for treating ulcerative colitis (UC), though the mechanisms underlying treatment failure are unknown. This study harnessed longitudinally collected colonic biopsies (n = 38) and fecal samples (n = 179) from 19 adults with mild-to-moderate UC undergoing serial FMT in which antimicrobial pre-treatm...
Baker, Nameer Zhalnina, Kateryna Yuan, Mengting Herman, Don Ceja-Navarro, Javier Sasse, Joelle Jordan, Jacob Bowen, Benjamin Wu, Liyou Fossum, Christina
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Plants release a wealth of metabolites into the rhizosphere that can shape the composition and activity of microbial communities in response to environmental stress. The connection between rhizodeposition and rhizosphere microbiome succession has been suggested, particularly under environmental stress conditions, yet definitive evidence is scarce. ...
Merkhassine, Michael Coch, Reilly Frederick, Carol Bennett, Lucinda Peng, Seth Morse, Benjamin Cummings, Bethany Loftus, John
Glucagon plays a central role in amino acid (AA) homeostasis. The dog is an established model of glucagon biology, and recently, metabolomic changes in people associated with glucagon infusions have been reported. Glucagon also has effects on the kidney; however, changes in urinary AA concentrations associated with glucagon remain under investigati...
Lorentzen, Georgia Łaniewski, Paweł Cui, Haiyan Mahnert, Nichole Mourad, Jamal Borst, Matthew Willmott, Lyndsay Chase, Dana Roe, Denise Herbst-Kralovetz, Melissa
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PURPOSE: Endometrial cancer is highly prevalent and lacking noninvasive diagnostic techniques. Diagnosis depends on histological investigation of biopsy samples. Serum biomarkers for endometrial cancer have lacked sensitivity and specificity. The objective of this study was to investigate the cervicovaginal environment to improve the understanding ...
Wang, Meng Wei, Tao Yu, Chaoji Li, Ruiyang Yin, Yunsi Yang, Hanchen Di, Run Xia, Xinyi Qin, Qi Tang, Yi
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Published in
Molecular neurobiology
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia worldwide. Dysregulation of various metabolism pathways may mediate the development of AD pathology and cognitive dysfunction. Variants of triggering receptor expressed on myeloid cells-2 (TREM2) are known to increase the risk of developing AD...
Mohr, Alex Sweazea, Karen Bowes, Devin Jasbi, Paniz Whisner, Corrie Krajmalnik-Brown, Rosa Jin, Yan Gu, Haiwei Klein-Seetharaman, Judith Arciero, Karen
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The gut microbiome (GM) modulates body weight/composition and gastrointestinal functioning; therefore, approaches targeting resident gut microbes have attracted considerable interest. Intermittent fasting (IF) and protein pacing (P) regimens are effective in facilitating weight loss (WL) and enhancing body composition. However, the interrelationshi...
Bae, Dam Dasari, Surendra Dennis, Courtney Evans, Charles R Gaul, David A Ilkayeva, Olga Ivanova, Anna A Kachman, Maureen T Keshishian, Hasmik Lanza, Ian R
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Regular exercise promotes whole-body health and prevents disease, but the underlying molecular mechanisms are incompletely understood1-3. Here, the Molecular Transducers of Physical Activity Consortium4 profiled the temporal transcriptome, proteome, metabolome, lipidome, phosphoproteome, acetylproteome, ubiquitylproteome, epigenome and immunome in ...
Yang, Xinlong Chen, Yinguang Liu, Weiguo Huang, Tingwen Yang, Yang Mao, Yuqing Meng, Yao
Published in
The Science of the total environment
Lead (Pb) can disrupt plant gene expression, modify metabolite contents, and influence the growth of plants. Cuminum cyminum L. is highly adaptable to adversity, but molecular mechanism by which it responds to Pb stress is unknown. For this study, transcriptomic and metabolomic sequencing was performed on root tissues of C. cyminum under Pb stress....
