Wang, Zhenhong Zeng, Lingjun Luo, Zhuanxi Wang, Yan Hao, Chunming
Published in
Environmental pollution (Barking, Essex : 1987)
The effects of different dissolved organic phosphorus (DOP) associated with distinct iron conditions (iron deficient (dFe), ferric ions (Fe3+), and colloidal iron (CFe)) on algal growth and arsenate (As(V)) metabolism were systematically evaluated and compared in Microcystis aeruginosa. Two chemical forms of DOP (D-glucose-6-phosphate (GP) and phyt...
Wang, Shaopeng Li, Xin Zhang, Bo Li, Yuxi Chen, Kexu Qi, Huimin Gao, Mengqi Rong, Jin Liu, Lin Wan, Yuzhou
...
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Tangshen formula (TSF) has an ameliorative effect on hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD), but the role played by the gut microbiota in this process is unknown. We conducted three batches of experiments to explore the role played by the gut microbiota: TSF administration, antibiotic treatment, and fecal microbial tr...
Zhang, Shudong Hou, Jinju Zhang, Xiaotong Cai, Tong Chen, Wenjie Zhang, Qiuzhuo
Published in
Chemosphere
Extensive use of oxytetracycline (OTC) and the generation of its corresponding resistance genes have resulted in serious environmental problems. Physical-biological combined remediation is an attractive method for OTC degradation because of its high remediation efficiency, stability, and environmental friendliness. In this study, an effective OTC-d...
Yin, Jia Liu, Shuang Li, Yongting Hu, Ligang Liao, Chunyang Jiang, Guibin
Published in
Environmental science & technology
Mono(2-ethylhexyl) phthalate (MEHP), as a highly toxic and biologically active phthalate metabolite, poses considerable risks to the environment and humans. Despite the existence of in vitro studies, there is a lack of in vivo experiments assessing its toxicity, particularly thyroid toxicity. Herein, we investigated the thyroid-disrupting effects o...
Ryan, Dylan Gerard Peace, Christian Graham Hooftman, Alexander
Published in
Journal of Innate Immunity
Background: Innate immune cells play a crucial role in responding to microbial infections, but their improper activation can also drive inflammatory disease. For this reason, their activation state is governed by a multitude of factors, including the metabolic state of the cell and, more specifically, the individual metabolites which accumulate int...
Liu, Huihui Xie, Ting Wang, Jiyun Wang, Xiao Han, Jing Huang, Zhihua Jiang, Lixia Nie, Zongxiu
Published in
Talanta
Hypoxic-ischemic encephalopathy (HIE) is a leading cause of neurological disability and even more serious fetal or neonatal asphyxia death. As the therapeutic time window is limited and timely intervention could have a better prognosis, elucidating the mechanisms underlying HIE and developing novel therapeutic strategies is of great importance. In ...
Mano, Yuji Nitanai, Ikumi Hotta, Koichiro
Published in
Journal of pharmaceutical and biomedical analysis
E7090, a novel fibroblast growth factor receptors inhibitor, is currently under clinical development for the treatment of patients with solid tumors. The previous assay was insufficient in detection sensitivity for E7090 and high exposure of a dealkylated metabolite, M2, was noted in a clinical trial at low doses. Thus, a sensitive assay for the si...
Kantner, Daniel S Megill, Emily Bostwick, Anna Yang, Vicky Bekeova, Carmen Van Scoyk, Alexandria Seifert, Erin L Deininger, Michael W Snyder, Nathaniel W
Published in
Analytical biochemistry
Acetyl-Coenzyme A is a central metabolite in catabolic and anabolic pathways as well as the acyl donor for acetylation reactions. Multiple quantitative measurement techniques for acetyl-CoA have been reported, including commercially available kits. Comparisons between techniques for acetyl-CoA measurement have not been reported. This lack of compar...
Tang, Xinmiao Cui, Yue Feng, Bo
Published in
Journal of pharmaceutical and biomedical analysis
Ulcerative colitis (UC) is a recurrent and palliative inflammatory bowel disease (IBD) begins in distal colon and spreads proximally to the entire colon, characterized by mucosal inflammation which reduces patients' quality of life and increases the risk of bowel cancer. Huangqin decoction (HQD), a classical Chinese formula recorded in Treatise on ...
Huang, Yixin
The everlasting battles between humans and bacteria entered a new stage with the discovery of antibiotics that saved millions of lives in the 20th century. However, the rise of antibiotic-resistant strains, often resistant to multiple classes of antibiotics, poses a renewed threat to human health. Compared to the quick and swift evolution of the re...
