Thitiset, Thakoon Damrongsakkul, Siriporn Yodmuang, Supansa Leeanansaksiri, Wilairat Apinun, Jirun Honsawek, Sittisak
Published in
Biomaterials Research
BackgroundA novel biodegradable scaffold including gelatin (G), chitooligosaccharide (COS), and demineralized bone matrix (DBM) could play a significant part in bone tissue engineering. The present study aimed to investigate the biological characteristics of composite scaffolds in combination of G, COS, and DBM for in vitro cell culture and in vivo...
Xiang, Shiqi Li, Zhong Fritch, Madalyn R. Li, La Velankar, Sachin Liu, Yuwei Sohn, Jihee Baker, Natasha Lin, Hang Tuan, Rocky S.
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Published in
Stem Cell Research & Therapy
BackgroundHuman bone marrow-derived mesenchymal stem cells (hBMSCs) can differentiate into adipocytes upon stimulation and are considered an appropriate cell source for adipose tissue engineering. In addition to biochemical cues, the stiffness of a substrate that cells attach to has also been shown to affect hBMSC differentiation potential. Of note...
Rawal, Shruti Patel, Mayur
Published in
Nano-Micro Letters
Lung cancer is a complex thoracic malignancy developing consequential to aberrations in a myriad of molecular and biomolecular signaling pathways. It is one of the most lethal forms of cancers accounting to almost 1.8 million new annual incidences, bearing overall mortality to incidence ratio of 0.87. The dismal prognostic scenario at advanced stag...
Huang, Qilin Cheng, Xiumei Luo, Chen Yang, Shuxu Li, Shuai Wang, Bing Yuan, Xiaohui Yang, Yi Wen, Yi Liu, Ruohong
...
Published in
Stem Cell Research & Therapy
BackgroundMesenchymal stem cells (MSCs) hold promising potential to treat systemic inflammatory diseases including severe acute pancreatitis (SAP). In our previous study, placental chorionic plate-derived MSCs (CP-MSCs) were found to possess superior immunoregulatory capability. However, the therapeutic efficacy of CP-MSCs on SAP and their underlyi...
Marinescu, Catalina-Iolanda Preda, Mihai Bogdan Burlacu, Alexandrina
Published in
Stem Cell Research & Therapy
BackgroundMesenchymal stem/stromal cells (MSC) represent adult cells with multipotent capacity. Besides their capacity to differentiate into multiple lineages in vitro and in vivo, increasing evidence points towards the immunomodulatory capacity of these cells, as an important feature for their therapeutic power. Although not included in the minima...
Carbonare, Luca Dalle Bertacco, Jessica Marchetto, Giulia Cheri, Samuele Deiana, Michela Minoia, Arianna Tiso, Natascia Mottes, Monica Valenti, Maria Teresa
Published in
Stem Cell Research & Therapy
BackgroundMethylsulfonylmethane (MSM) is a nutraceutical compound which has been indicated to counteract osteoarthritis, a cartilage degenerative disorder. In addition, MSM has also been shown to increase osteoblast differentiation. So far, few studies have investigated MSM role in the differentiation of mesenchymal stem cells (MSCs), and no study ...
He, Ruohang Han, Chaoqun Li, Ying Qian, Wei Hou, Xiaohua
Published in
Frontiers in Cell and Developmental Biology
BackgroundMesenchymal stem cells (MSCs) treatment showed promising results in inflammatory bowel disease in both rodent models and patients. Nevertheless, previous studies conducted conflicting results on preclinical tumor models treated with MSCs concerning their influence on tumor initiation and progression. This study is designed to demonstrate ...
Özgül Özdemir, Rabia Bilge Özdemir, Alper Tunga Kırmaz, Cengiz Ovalı, Ercüment Ölmez, Ercüment Kerem, Hakan Evrenos, Mustafa Kürşat Deniz, Günnur
Published in
Stem cell reviews and reports
The etiopathogenesis of chronic spontaneous urticaria (CSU) is not fully elucidated, and almost 30-40% of patients are resistant to treatments; therefore, there is still a need for the development of new and effective treatments. This study aimed to develop experimental cellular therapy for CSU patients resistant to current treatment options. Autol...
Nogueira-Pedro, Amanda Makiyama, Edson Naoto Segreto, Helena Regina Comodo Fock, Ricardo Ambrósio
Published in
Stem cell reviews and reports
Ionizing radiation (IR) is an important medical tool. Despite the effects associated with high-dose radiation during or after treatment, as well as in accidental exposures, the direct or indirect effect of low-dose IR in cells remain poorly documented. IR can affect the tissue microenvironment, including mesenchymal stem cells (MSCs), which have hi...
Li, Tao Wan, Yingchun Su, Ziyuan Li, Jiayu Han, Minna Zhou, Changyu
Published in
Digestive diseases and sciences
Exosomes are potential tools for disease control by regulating intercellular communication through carrying proteins and RNAs between cells or remote organs. Exosome activities have aroused wide concerns in cancer biology and malignancy control. This study was performed to explore the roles of mesenchymal stem cell (MSC)-derived exosomes in colorec...
