Jeyaraman, Madhan John, Albin Koshy, Santhosh Ranjan, Rajni Anudeep, Talagavadi Channaiah Jain, Rashmi Swati, Kumari Jha, Niraj Kumar Sharma, Ankur Kesari, Kavindra Kumar
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Published in
Biochimica et biophysica acta. Molecular basis of disease
The coronavirus disease 2019 (COVID-19) has been threatening the globe since the end of November 2019. The disease revealed cracks in the health care system as health care providers across the world were left without guidelines on definitive usage of pharmaceutical agents or vaccines. The World Health Organization (WHO) declared COVID-19 as a pande...
Tang, Yaya Zhou, Yan Li, Hong-Jun
Published in
Stem Cell Research & Therapy
Stem cells can be used for regenerative medicine and as treatments for disease. The application of tissue engineering-related transplantation, stem cells, and local changes in the microenvironment is expected to solve major medical problems. Currently, most studies focus on tissue repair and regeneration, and mesenchymal stem cells (MSCs) are among...
da Silva-Junior, Almir Jordão Mesentier-Louro, Louise Alessandra Nascimento-dos-Santos, Gabriel Teixeira-Pinheiro, Leandro Coelho Vasques, Juliana F. Chimeli-Ormonde, Luiza Bodart-Santos, Victor de Carvalho, Luiza Rachel Pinheiro Santiago, Marcelo Felippe Mendez-Otero, Rosalia
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Published in
Stem Cell Research & Therapy
Background Optic-nerve injury results in impaired transmission of visual signals to central targets and leads to the death of retinal ganglion cells (RGCs) and irreversible vision loss. Therapies with mesenchymal stem cells (MSCs) from different sources have been used experimentally to increase survival and regeneration of RGCs. Methods We investig...
Kaspi, Haggai Semo, Jonathan Abramov, Nathalie Dekel, Chen Lindborg, Stacy Kern, Ralph Lebovits, Chaim Aricha, Revital
Published in
Stem Cell Research & Therapy
Background One of the most severe complications of the current COVID-19 pandemic is acute respiratory distress syndrome (ARDS). ARDS is caused by increased amounts of pro-inflammatory cytokines, leading to lung damage and loss of lung function. There are currently no effective therapies for combatting ARDS. Mesenchymal stem cells (MSCs) have been s...
Takashima, Shinichiro Usui, Soichiro Inoue, Oto Goten, Chiaki Yamaguchi, Kosei Takeda, Yusuke Cui, Shihe Sakai, Yoshio Hayashi, Kenshi Sakata, Kenji
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Published in
Scientific Reports
Cardiomyocyte regeneration is limited in adults. The adipose tissue-derived stromal vascular fraction (Ad-SVF) contains pluripotent stem cells that rarely transdifferentiate into spontaneously beating cardiomyocyte-like cells (beating CMs). However, the characteristics of beating CMs and the factors that regulate the differentiation of Ad-SVF towar...
Stachecka, Joanna Kolodziejski, Pawel A. Noak, Magdalena Szczerbal, Izabela
Published in
Scientific Reports
A characteristic spatial distribution of the main chromatin fractions is observed in most mammalian cell nuclei, with euchromatin localized in the interior and heterochromatin at the nuclear periphery. It has been shown that interactions of heterochromatin with the nuclear lamina are necessary to establish this conventional architecture. Adipocytes...
Oh, Min-Seok Lee, Seul-Gi Lee, Gwan-Ho Kim, C-Yoon Kim, Eun-Young Song, Jong Han Yu, Byung-Yong Chung, Hyung Min
Published in
Scientific Reports
Despite the tremendous advancements made in cell tracking, in vivo imaging and volumetric analysis, it remains difficult to accurately quantify the number of infused cells following stem cell therapy, especially at the single cell level, mainly due to the sensitivity of cells. In this study, we demonstrate the utility of both liquid scintillator co...
Zhai, Weichao Tan, Jerome Russell, Tobias Chen, Sixun McGonagle, Dennis Win Naing, May Yong, Derrick Jones, Elena
Published in
Scientific Reports
Human mesenchymal stromal cells (hMSCs) have demonstrated, in various preclinical settings, consistent ability in promoting tissue healing and improving outcomes in animal disease models. However, translation from the preclinical model into clinical practice has proven to be considerably more difficult. One key challenge being the inability to perf...
Galindo, Sara de la Mata, Ana López-Paniagua, Marina Herreras, Jose M. Pérez, Inmaculada Calonge, Margarita Nieto-Miguel, Teresa
Published in
Stem Cell Research & Therapy
Mesenchymal stem cells (MSCs) have unique and beneficial properties and are currently used to treat a broad variety of diseases. These properties include the potential for differentiation into other cell types, secretion of different trophic factors that promote a regenerative microenvironment, anti-inflammatory actions, selective migration to dama...
Zhou, Pengyu Liu, Hao Liu, Ximao Ling, Xiao Xiao, Zezhou Zhu, Peng Zhu, Yufeng Lu, Jun Zheng, Shaoyi
Published in
Stem Cell Research & Therapy
BackgroundIn heart transplantation, donor hearts inevitably suffer from ischemia/reperfusion (I/R) injury, which leads to primary graft dysfunction and affects patients’ survival rate. Bone marrow mesenchymal stem cells (BMSCs) have been reported to attenuate myocardial I/R injury via their paracrine effects, which can be enhanced by hypoxic precon...
