Liu, Xue Yuan, Jie Zhou, Huizhi Wang, Yuyao Tian, Guoyu Liu, Xueying Wang, Xinhui Tang, Mulin Meng, Xue Kou, Chunjia
...
Published in
The Journal of clinical endocrinology and metabolism
Systemic lupus erythematosus (SLE) and hypothyroidism often coexist in observational studies; however, the causal relationship between them remains controversial. Complementary genetic approaches, including genetic correlation, Mendelian randomization (MR), and colocalization analysis, were conducted to assess the potential causal association betwe...
Flatby, Helene M Ravi, Anuradha Damås, Jan K Solligård, Erik Rogne, Tormod
Published in
BMC medicine
Micronutrients play an essential role at every stage of the immune response, and deficiencies can therefore lead to increased susceptibility to infections. Previous observational studies and randomized controlled trials of micronutrients and infections are limited. We performed Mendelian randomization (MR) analyses to evaluate the effect of blood l...
Jiang, Sujing Xu, Zhiyong Shi, Yueli Liang, Sibei Jiang, Xinyuan Xiao, Mingshu Wang, Kai Ding, Liren
Published in
Frontiers in Endocrinology
Background Insulin-like growth factor-1 (IGF-1) display a vital role in in the pathogenesis of lung diseases, however, the relationship between circulating IGF-1 and lung disease remains unclear. Methods Single nucleotide polymorphisms (SNPs) associated with the serum levels of IGF-1 and the outcomes data of lung diseases including asthma, chronic ...
Guo, Xiaoming Wang, Dingkun Ying, Caidi Hong, Yuan
Published in
Frontiers in Neuroscience
Background Accumulating evidence of clinical and neuroimaging studies indicated that migraine is related to brain structural alterations. However, it is still not clear whether the associations of brain structural alterations with migraine are likely to be causal, or could be explained by reverse causality confounding. Methods We carried on a bidir...
Qi, Li Bao, Wenzhao Wang, Sai Ding, Xiaoxu Li, Wei
Published in
Frontiers in Oncology
Background It was reported that educational attainment and household income are associated with oropharyngeal cancer. However, whether such an association is causal is still unknown. Methods The Mendelian randomization (MR) design was performed to disentangle their causal relationship. Initially, genetic variants proxied for educational attainment ...
Chalitsios, Christos V Tsilidis, Kostas K Tzoulaki, Ioanna
Published in
Journal of the American Academy of Dermatology
Wang, Lijuan Li, Xue Montazeri, Azita MacFarlane, Amanda J. Momoli, Franco Duthie, Susan Senekal, Marjanne Eguiagaray, Ines Mesa Munger, Ron Bennett, Derrick
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Published in
The American journal of clinical nutrition
Background Although a number of health outcomes such as cardiovascular diseases, metabolic-related outcomes, neurological disorders, pregnancy outcomes and cancers have been identified in relation to B vitamins, evidence is of uneven quality and volume, and there is uncertainty about putative causal relationships. Objectives To explore the effects ...
Wang, Xinghao Sun, Jing Li, Jia Cai, Linkun Chen, Qian Wang, Yiling Yang, Zhenghan Liu, Wenjuan Lv, Han Wang, Zhenchang
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Published in
Frontiers in Endocrinology
Background It is well known that the occurrence and development of ovarian cancer are closely related to the patient’s weight and various endocrine factors in the body. Aim Mendelian randomization (MR) was used to analyze the bidirectional relationship between insulin related characteristics and ovarian cancer. Methods The data on insulin related c...
Du, Runming Zhou, Yi You, Chong Liu, Kevin King, Daniel A Liang, Zhi-Sheng Ranson, Janice M Llewellyn, David J Huang, Jie Zhang, Zhenyu
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Published in
International journal of stroke : official journal of the International Stroke Society
Observational studies have found an association between attention-deficit/hyperactivity disorder (ADHD) and ischemic stroke. The purpose of this study was to investigate whether genetic liability to ADHD has a causal effect on ischemic stroke and its subtypes. In this two-sample Mendelian randomization (MR) study, genetic variants (nine single-nucl...
Chalitsios, Christos V Georgiou, Andrea Bouras, Emmanouil Evangelou, Evangelos Gill, Dipender Tsilidis, Kostas K Tzoulaki, Ioanna
Published in
Journal of the American Academy of Dermatology
Potentially modifiable risk factors have previously been investigated only in conventional observational studies. To assess whether genetically predicted exposures to modifiable factors are associated with the risk of psoriasis. Two-sample Mendelian randomization (MR) analysis. An increased risk of psoriasis was noted for genetically predicted life...
