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Hypoxia-responsive liposome enhances intracellular delivery of photosensitizer for effective photodynamic therapy.

Published in Journal of controlled release : official journal of the Controlled Release Society

Liposomes, especially polyethylene glycol (PEG)-modified long-circulating liposomes, have been approved for market use, due to good biocompatibility, passive tumor targeting, and sustained drug release. PEG-modified long-circulating liposomes address issues such as poor stability and rapid clearance by the reticuloendothelial system. However, they ...

Cellulose nanocrystal-annealed hydrogel system for local chemo-metabolic therapy of melanoma.

Published in Journal of controlled release : official journal of the Controlled Release Society

A cellulose nanocrystal (CNC)-annealed hydrogel (CAH) structure, including doxorubicin (DOX) and 2-deoxy-d-glucose (2DG), was developed for local chemo-metabolic therapy (LCMT) of melanoma. DOX has been used as a chemotherapeutic agent because of its intercalation into DNA and generation of free radicals. 2DG has been used as a glycolytic inhibitor...

Genetic Factors Associated with Clinical Response in Melanoma Patients Treated with Talimogene Laherparapvec: A Single-I...

Published in Annals of surgical oncology

Talimogene laherparapvec (T-VEC) is a modified herpes simplex virus type 1 (HSV-1) and the first oncolytic virus to be approved for the treatment of unresectable melanoma. We assessed whether there are tumor-intrinsic genetic factors that are associated with tumor control. A single-institution, retrospective analysis of melanoma patients treated wi...

Are Positive Biopsy Margins in Melanoma Significant?: A Cohort Study of Micro- Versus Macroscopic Margin Status and Thei...

Published in Annals of surgical oncology

Presence of positive biopsy margins in melanoma can provoke anxiety over potential disease progression from delays to surgical excision, but their impact on outcomes is unknown. We aimed to compare the presence of residual melanoma in the surgical excision specimen and survival between patients with negative, microscopically positive, and macroscop...

Follicular dendritic cell sarcoma involving the parotid gland with expression of the melanocytic marker PRAME.

Follicular dendritic cell sarcoma is a rare mesenchymal neoplasm arising from follicular dendritic cells (FDC) of lymphoid follicles. While the majority of FDC sarcoma cases arise within lymph nodes, approximately 30% manifest in extranodal sites. Only 4 prior occurrences of intra-parotid FDC sarcomas have been documented. We are reporting a rare c...

Perceptions, knowledge and attitudes of healthcare professionals regarding the promotion of physical activity for melano...

Published in Annales de dermatologie et de venereologie

Myopericytoma mimicking subcutaneous melanoma metastasis.

Published in Journal of ultrasound

The importance of ultrasound-guided biopsy: lesson from a case of liver metastasis from uveal melanoma.

Published in Journal of ultrasound

Melanoma is an extremely aggressive malignant neoplasm. Uveal melanoma is the most common primary intraocular malignancy in adults, representing 3-5% of all melanomas. Liver metastases can be clinically detected in 10-20% of patients with metastatic disease from cutaneous melanoma. However, while liver is typically not the first site of disease spr...

Cutaneous melanoma and purinergic modulation by phenolic compounds.

Published in Purinergic signalling

Cutaneous melanoma is a complex pathology that still has only treatments that lack efficiency and offer many adverse effects. Due to this scenario emerges the need to analyze other possible treatments against this disease, such as the effect of phenolic compounds. These substances have proven antitumor effects, but still have not been fully explore...