Cytogenetic and molecular aberrations and worse outcome for male patients in systemic mastocytosis
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status: published
Determinants of placental iodine concentrations in a mild-to-moderate iodine-deficient population: an ENVIRONAGE cohort ...
BACKGROUND: Iodine is an essential trace element for the production of thyroid hormones, and plays a key role during the gestational period for optimal foetal growth and (neuro-)development. To this day, iodine deficiency remains a global burden. Previous studies indicate that the placenta can store iodine in a concentration-dependent manner and se...
The Prevalence of Undiagnosed Age-Related Sight-Threatening Diseases in Self-Proclaimed Healthy Individuals
status: published
Serial correlation structures in latent linear mixed models for analysis of multivariate longitudinal ordinal responses
We propose a latent linear mixed model to analyze multivariate longitudinal data of multiple ordinal variables, which are manifestations of fewer continuous latent variables. We focus on the latent level where the effects of observed covariates on the latent variables are of interest. We incorporate serial correlation into the variance component ra...
The Frequency of Ovarian Hyperstimulation Syndrome and Thromboembolism with Originator Recombinant Human Follitropin Alf...
BACKGROUND: Recombinant human follitropin alfa (r-hFSH) is used for ovarian stimulation as part of medically assisted reproduction. There is a risk for ovarian hyperstimulation syndrome (OHSS) with r-hFSH treatment, and an increased risk for thromboembolic events in the presence of pregnancy with OHSS. OBJECTIVES: To report the frequency of OHSS an...
Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium
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status: published
Magnitude, demographics and dynamics of the effect of the first wave of the COVID-19 pandemic on all-cause mortality in ...
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The Coronavirus Disease 2019 (COVID-19) pandemic has changed many social, economic, environmental and healthcare determinants of health. We applied an ensemble of 16 Bayesian models to vital statistics data to estimate the all-cause mortality effect of the pandemic for 21 industrialized countries. From mid-February through May 2020, 206,000 (95% cr...
Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium
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The cytokine TNF drives inflammatory diseases, e.g., Crohn's disease. In a mouse model of TNF-induced systemic inflammatory response syndrome (SIRS), severe impact on intestinal epithelial cells (IECs) is observed. Zinc confers complete protection in this model. We found that zinc no longer protects in animals which lack glucocorticoids (GCs), or e...
On the relationship between association and surrogacy when both the surrogate and true endpoint are binary outcomes
The relationship between association and surrogacy has been the focus of much debate in the surrogate marker literature. Recently, the individual causal association (ICA) has been introduced as a metric of surrogacy in the causal inference framework, when both the surrogate and the true endpoint are normally distributed and when both are binary. Ea...
A biomimetic VLP influenza vaccine with interior NP/exterior M2e antigens constructed through a temperature shift-based ...
Here we present a biomimetic strategy towards an influenza vaccine design based on hepatitis B virus core virus-like particles (HBc VLP). To this end, a temperature-shift based encapsulation process based on analysis of the unique thermal-associated structural flexibility of HBc VLP nanocages was proposed and proved efficient for encapsulation of a...
