Depressive brooding following a stressful event predicts negative affect and neuroendocrine responses related to psychological stress. The dorsolateral prefrontal cortex (DLPFC) has been associated with the top-down regulation of thoughts and emotions, and abnormal neural activity within this region has been associated with increased psychological ...
Published in Universal Access in the Information Society
Designing for Universal Access requires designers to have a good understanding of the full range of users and their capabilities, appropriate datasets, and the most suitable tools and techniques. Education clearly plays an important role in helping designers acquire the knowledge and skills necessary to find the relevant information about the users...
Published in Human Heredity
Objectives: Identifying drivers of complex traits from the noisy signals of genetic variation obtained from high-throughput genome sequencing technologies is a central challenge faced by human geneticists today. We hypothesize that the variants involved in complex diseases are likely to exhibit non-neutral evolutionary signatures. Uncovering the ev...
Are you interested in improving mental health information available on Wikipedia? Do you want to utilize your librarian research skills towards making Wikipedia a better, evidence-based resource? Have you always wanted to participate in or learn how to host your own edit-a-thon? In preparation for the National Network of Libraries of Medicine Fall ...
Recent advances with the bacterial CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) defense system as genome editing tools have opened a new avenue for targeting disease-causing mutations. The programmability of the Cas9 endonuclease by RNA makes it a potentially powerful therapeutic tool to correct such mutations. The CRISPR-Cas9...
Published in Nanomaterials (Basel, Switzerland)
For stem cell-based therapies, the fate and distribution of stem cells should be traced using non-invasive or histological methods and a nanomaterial-based labelling agent. However, evaluation of the biophysical effects and related biological functions of nanomaterials in stem cells remains challenging. Here, we aimed to investigate the biophysical...
In this work, the solubilities of pharmaceutical cocrystals in solvent/anti-solvent systems were predicted using PC-SAFT in order to increase the efficiency of cocrystal formation processes. Modeling results and experimental data were compared for the cocrystal system nicotinamide/succinic acid (2:1) in the solvent/anti-solvent mixtures ethanol/wat...
David will share his research and personal experience about the importance of recognizing that addiction is a chronic brain disease that affects the whole family. “We know what to do when a person is sick with any other problem.” He will discuss how co-existing psychiatric disorders such as anxiety or depression can be underlying conditions and mus...
The National Network of Libraries of Medicine, Greater Midwest Region (NNLM GMR) received funding to support the evaluation and development of an asynchronous consumer health information course. Requirements of this project included: incorporating recommendations from NNLM instructors, National Library of Medicine staff and public library staff; pi...
