Tandem mass spectrometry (MS/MS) is a highly sensitive and specific technique. Thanks to the development of triple quadrupole analyzers, it is becoming more widely used in laboratories working in the field of inborn errors of metabolism. We review here the state of the art of this technique applied to the diagnosis of lysosomal storage disorders (L...
Tandem mass spectrometry (MS/MS) is a highly sensitive and specific technique. Thanks to the development of triple quadrupole analyzers, it is becoming more widely used in laboratories working in the field of inborn errors of metabolism. We review here the state of the art of this technique applied to the diagnosis of lysosomal storage disorders (L...
Creatine transporter is currently the focus of renewed interest with emerging roles in brain neurotransmission and physiology, and the bioenergetics of cancer metastases. We here report on amendments of a standard creatine uptake assay which might help clinical chemistry laboratories to extend their current range of measurements of creatine and met...
Carnitine palmitoyltransferase type 2 (CPT2) deficiency, a mitochondrial fatty acid oxidation disorder (MFAOD), is a cause of myopathy in its late clinical presentation. As for other MFAODs, its diagnosis may be evocated when blood acylcarnitine profile is abnormal. However, a lack of abnormalities or specificity in this profile is not exclusive of...
Carnitine palmitoyltransferase type 2 (CPT2) deficiency, a mitochondrial fatty acid oxidation disorder (MFAOD), is a cause of myopathy in its late clinical presentation. As for other MFAODs, its diagnosis may be evocated when blood acylcarnitine profile is abnormal. However, a lack of abnormalities or specificity in this profile is not exclusive of...
In the ancient Greek period, two opposite views of the hot spring treatment appeared: the first treated it as the miracle by the Olympus gods, while the other treated it as a subject of scientific enquiry, which the Hippocrates School supported. Afterwards, when the plague prevailed in the Middle Ages, Ambroise Palais, king's doctor, argued that th...
Introduction: Obstetrical emergencies are a high-risk yet infrequent occurrence in the emergency department. While U.S. emergency medicine (EM) residency graduates are required to perform 10 low-risk normal spontaneous vaginal deliveries, little is known about how residencies prepare residents to manage obstetrical emergencies. We sought to profile...
Ready-to-eat shrimp processing is challenging due to the complex biological design with the shell tightly connected to the meat. Several techniques have been developed to weaken or loosen this connection, thus facilitating the subsequent peeling. The loosening process is typically undertaken by maturing the shrimps on ice or in brine, which require...
Mid-infrared hyperspectral imaging has in the past decade emerged as a promising tool for medical diagnostics. In this work, nonlinear frequency upconversion based hyperspectral imaging in the 6 to 8 mu m spectral range is presented for the first time, using both broadband globar and narrowband quantum cascade laser illumination. AgGaS2 is used as ...
There is general pressure throughout the world's fisheries for the industry to have greater involvement not only in the development of fishing gears but also in the testing and documentation of their effect. In the European Union, the Common Fisheries Policy of 2013, together with the proposed reform of the technical measures regulation, highlights...
