Devlin, Michael-John Miller, Rowan
Published in
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Understanding the genomic complexity of high-grade serous ovarian cancer is now essential in guiding patient management, particularly in the first-line setting. Our knowledge in this area has expanded rapidly in recent years, with biomarkers developing in parallel to agents designed to exploit cancer-associated genetic aberrations. In this review w...
McCague, C Ramlee, S Reinius, M Selby, I Hulse, D Piyatissa, P Bura, V Crispin-Ortuzar, M Sala, E Woitek, R
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Radiomics is a rapidly developing field of research focused on the extraction of quantitative features from medical images, thus converting these digital images into minable, high-dimensional data, which offer unique biological information that can enhance our understanding of disease processes and provide clinical decision support. To date, most r...
Buck, Eva Haslam, Alyson Tuia, Jordan Prasad, Vinay
ImportanceThe practice of using medical writers to communicate scientific information has gained popularity, but it may affect how and what information is communicated.ObjectiveTo assess characteristics of oncology trials that use medical writers and whether there is an association between the use of medical writers and trial success or the primary...
Haslam, Alyson Olivier, Timothée Tuia, Jordan Prasad, Vinay
IntroductionWe sought to characterise oncology basket and umbrella trials that have been implemented, determine how many have been completed, and calculate the response rate, by tumour type and drug target.MethodsWe conducted a retrospective, cross-sectional review of PubMed, Embase, and clinicaltrials.gov for all oncology basket and umbrella trial...
Härmä, Mikko Ojajärvi, Anneli Koskinen, Aki Lie, Jenny-Anne Hansen, Johnni
Published in
Occupational and environmental medicine
To examine the association of shift work with and without night work with breast cancer among women in the public sector. Using the Finnish Public Sector cohort study (N=33 359, mean age of 40.6 years at baseline), we investigated the associations of shift work and potential confounders with incident breast cancer. Exposure to permanent day work or...
Haslam, Alyson Olivier, Timothée Tuia, Jordan Prasad, Vinay
BackgroundThe utilization of basket trials in oncology has gained popularity because of the drive for precision medicine and the increasing ease of genetically profiling tumors. However, it is unknown if this has translated into patient benefit, either through higher response rates because of precision treatment or because of increasing options for...
Geukens, T Brandão, M Laenen, A Collignon, Joëlle Van Marcke, C Louviaux, I Demey, W Van Wambeke, S Schrijvers, D Lecomte, S
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peer reviewed / [en] BACKGROUND: Solid cancer is an independent prognostic factor for poor outcome with COVID-19. As guidelines for patient management in that setting depend on retrospective efforts, we here present the first analyses of a nationwide database of patients with cancer hospitalized with COVID-19 in Belgium, with a focus on changes in ...
Walia, Anushka Haslam, Alyson Prasad, Vinay
IntroductionThe number of oncologic drugs approved by the US Food and Drug Administration (FDA) on the basis of surrogate endpoints is rising. However, many surrogates have not demonstrated a correlation with clinically meaningful outcomes like overall survival. We sought to investigate surrogate validation studies conducted by the FDA over the pas...
Powell, Kerrington Prasad, Vinay
In biomedicine, randomized controlled trials are regarded as the gold standard of evidence owing to their ability to minimize confounding factors that may influence results. Randomized trials that are properly designed serve as a basis for drug regulation and national guideline development. Despite the many advantages of the study design, there are...
Panovska, Dena; 118350; De Smet, Frederik; 44821;
Glioblastoma remains the most malignant and intrinsically resistant brain tumour in adults. Despite intensive research over the past few decades, through which numerous potentially druggable targets have been identified, virtually all clinical trials of the past 20 years have failed to improve the outcome for the vast majority of GBM patients. The ...
