Toward further implementation of continuous tablet manufacturing, one key issue is the time needed for start-up operation because it could lead to lower product yield and reduced economic performance. The behavior of the start-up operation is not well understood / moreover, the definition of the start-up time is still unclear. This work investigate...
Case-mix heterogeneity across studies complicates meta-analyses. As a result of this, treatments that are equally effective on patient subgroups may appear to have different effectiveness on patient populations with different case mix. It is therefore important that meta-analyses be explicit for what patient population they describe the treatment e...
We characterize the nuclearity of the Beurling-Björck spaces $\mathcal{S}^{(\omega)}_{(\eta)}(\mathbb{R}^d)$ and $\mathcal{S}^{\{\omega\}}_{\{\eta\}}(\mathbb{R}^d)$ in terms of the defining weight functions $\omega$ and $\eta$.
Published in Nature Communications
To benchmark single cell bioinformatics tools, data simulators can provide a robust ground truth. Here the authors present dyngen, a multi-modal simulator, and apply it to aligning cell developmental trajectories, cell-specific regulatory network inference and estimation of RNA velocity.
This paper addresses the risk-minimization problem, with and without mortality securitization, à la Föllmer–Sondermann for a large class of equity-linked mortality contracts when no model for the death time is specified. This framework includes situations in which the correlation between the market model and the time of death is arbitrary general, ...
Published in Scientific Reports
We analyze the stability of a unique coexistence equilibrium point of a system of ordinary differential equations (ODE system) modelling the dynamics of a metapopulation, more specifically, a set of local populations inhabiting discrete habitat patches that are connected to one another through dispersal or migration. We assume that the inter-patch ...
Field-applicable, high-quality, and low-cost diagnostic tools are urgently needed for Taenia solium. The aim of this paper is to describe the design, challenges, and rationale for the design of a diagnostic accuracy study in low-resource community settings in Zambia. The trial was designed as a prospective study with a two-stage design to evaluate ...
Published in Communications Physics
Mediation analysis aims to clarify the nature of the relationship between two variables, by elucidating the role of a third variable, which can allow or suppress the relationship, or being simply not involved in the process. The authors introduce this framework in the analysis of three-layered multiplex networks, assessing whether a link between tw...
Motivated by mapping adverse artifactual events caused by body movements in electroencephalographic (EEG) signals, we present a functional independent component analysis based on the spectral decomposition of the kurtosis operator of a smoothed principal component expansion. A discrete roughness penalty is introduced in the orthonormality constrain...
Published in Scientific Reports
Most reports on AKI claim to use KDIGO guidelines but fail to include the urinary output (UO) criterion in their definition of AKI. We postulated that ignoring UO alters the incidence of AKI, may delay diagnosis of AKI, and leads to underestimation of the association between AKI and ICU mortality. Using routinely collected data of adult patients ad...
