Colella, Francesco Scillitani, Giovanni Pierri, Ciro Leonardo
Published in
Toxicology
Mitochondria are subcellular organelles involved in cell metabolism and cell life-cycle. Their role in apoptosis regulation makes them an interesting target of new drugs for dealing with cancer or rare diseases. Several peptides and proteins isolated from animal and plant sources are known for their therapeutic properties and have been tested on ca...
Iakimova, E.T. Yordanova, Zhenia P. Cristescu, Simona M. Harren, F.J.M. Woltering, E.J.
The production of volatile organic compounds (VOCs) during programmed cell death (PCD) is still insufficiently studied and their implication in the process is not well understood. The present study demonstrates that the release of VOSCs with presumed antioxidant capacity (methanethiol, dimethylsulfide and dimethyldisulfide) accompanies the cell dea...
Chagas Vinhote, Juliana Freire Lima, Danya Bandeira Pessoa Bezerra de Menezes, Ramon Roseo P... Mello, Clarissa Perdigao Souza, Bibiana Monson de Havt, Alexandre Palma, Mario Sergio Santos, Ricardo Pires dos Albuquerque, Eudenilson Lins de Freire, Valder Nogueira
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Chagas disease, considered a neglected disease, is a parasitic infection caused by Trypanosoma cruzi, which is endemic throughout the world. Previously, the antimicrobial effect of Mastoparan (MP) from Polybia paulista wasp venom against bacteria was described. To continue the study, we report in this short communication the antimicrobial effect of...
da Silva, Annielle Mendes Brito Silva-Gonçalves, Laíz Costa Oliveira, Fernando Augusto Arcisio-Miranda, Manoel
Published in
Molecular Neurobiology
Glioblastoma multiforme is the most common and lethal malignant brain tumor. Because of its complexity and heterogeneity, this tumor has become resistant to conventional therapies and the available treatment produces multiple side effects. Here, using multiple experimental approaches, we demonstrate that three mastoparan peptides—Polybia-MP1, Masto...
Irazazabal, Luz N Porto, William F Ribeiro, Suzana M Casale, Sandra Humblot, Vincent Ladram, Ali Franco, Octavio L
Published in
Biochimica et biophysica acta
The emergence of antibiotic-resistant clinical isolates and the decreased rate of development of new antibiotics are a constant threat to human health. In this context, the therapeutic value of mastoparan (MP), a toxin from wasp venom, has been extensively studied. However, since MP shows significant cytotoxic activities, further optimization is ne...
GONÇALVES, J. RANGEL, M. BIOLCHI, A. ALVES, E. MOREIRA, K. SILVA, L. MORTARI, M.
bitstream/item/180096/1/1-s2.0-S0041010116302112-main.pdf
silva, juliana monge-fuentes, victoria gomes, flávia lopes, kamila anjos, lilian campos, gabriel arenas, claudia biolchi, andréia gonçalves, jacqueline galante, priscilla
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Neurodegenerative diseases are relentlessly progressive, severely impacting affected patients, families and society as a whole. Increased life expectancy has made these diseases more common worldwide. Unfortunately, available drugs have insufficient therapeutic effects on many subtypes of these intractable diseases, and adverse effects hamper conti...
de Azevedo, Ricardo A Figueiredo, Carlos R Ferreira, Adilson K Matsuo, Alisson L Massaoka, Mariana H Girola, Natalia Auada, Aline V V Farias, Camyla F Pasqualoto, Kerly F M Rodrigues, Cecília P
...
Published in
Peptides
Mastoparan is an α-helical and amphipathic tetradecapeptide obtained from the venom of the wasp Vespula lewisii. This peptide exhibits a wide variety of biological effects, including antimicrobial activity, increased histamine release from mast cells, induction of a potent mitochondrial permeability transition and tumor cell cytotoxicity. Here, the...
Azevedo, Ricardo A. de Figueiredo, Carlos R. Ferreira, Adilson K. Matsuo, Alisson L. Massaoka, Mariana H. Girola, Natalia Auada, Aline V. V. Farias, Camyla F. Pasqualoto, Kerly F. M. Rodrigues, Cecilia P.
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Web of Science
Souza, Bibiana Monson de Cabrera, Marcia Perez Dos Santos Gomes, Paulo Cesar Dias, Nathalia Baptista Stabeli, Rodrigo Guerino Leite, Natalia Bueno Neto, João Ruggiero Palma, Mario Sergio
In this study, a series of mastoparan analogs were engineered based on the strategies of Ala and Lys scanning in relation to the sequences of classical mastoparans. Ten analog mastoparans, presenting from zero to six Lys residues in their sequences were synthesized and assayed for some typical biological activities for this group of peptide: mast c...
