Volf, Carlo Aggestrup, Anne Sofie Svendsen, Signe Dunker Hansen, Torben Skov Petersen, Paul Michael Dam-Hansen, Carsten Knorr, Ulla Petersen, Ema Erkocevic Engstrøm, Janus Hageman, Ida
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Published in
Pilot and Feasibility Studies
BackgroundRetrospective studies conducted in psychiatric wards have indicated a shorter duration of stay for depressed inpatients in bright compared to dim daylight-exposed rooms, pointing to a possible antidepressant effect of daylight conditions. Dynamic LED lighting, aiming to mimic daylight conditions, are currently been installed in several ho...
Kuehl, Linn K Deuter, Christian E Hellmann-Regen, Julian Kaczmarczyk, Michael Otte, Christian Wingenfeld, Katja
Published in
Progress in neuro-psychopharmacology & biological psychiatry
Major depressive disorder (MDD) has been associated with changes in the biological stress systems, including the locus coeruleus-noradrenergic system. Accumulated evidence suggests an upregulation of central alpha2-receptors, leading to decreased noradrenergic activity on a central level in MDD patients. Adverse childhood experiences (ACE) such as ...
Murthy, Naga Venkatesha Xu, Rengyi Zhong, Wei Harvey, Philip D
Published in
Journal of affective disorders
Patients with major depressive disorder (MDD) show impairments in cognitive functioning, including deficits on performance-based measures of functional capacity. A proportion of patients with MDD may achieve higher scores at baseline, and may not show a detectable response to treatment. How to identify these cases is the goal of this investigation....
Yuan, Hsinsung Zhu, Xiao Tang, Weijun Cai, Yiyun Shi, Shenxun Luo, Qiang
Published in
Journal of affective disorders
Early improvement (EI) following treatment with antidepressants is a widely reported predictor to the treatment response. This study aimed to identify the resting-state functional connectivity (rs-FC) and its related clinical features that link the treatment response at the time of EI. This study included 23 first-episode treatment-naive patients w...
Krepel, Noralie Rush, A John Iseger, Tabitha A Sack, Alexander T Arns, Martijn
Published in
Psychological medicine
Few studies focused on the relationship between psychological measures, major depressive disorder (MDD) and repetitive transcranial magnetic stimulation (rTMS) response. This study investigated several psychological measures as potential predictors for rTMS treatment response. Additionally, this study employed two approaches to evaluate the robustn...
Luo, Zhicheng Li, Yuqian Hou, Yitan Liu, Xiaotian Jiang, Jingjing Wang, Yan Liu, Xue Qiao, Dou Dong, Xiaokang Li, Ruiying
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Published in
BMC Public Health
BackgroundThis study aims to investigate the prevalence and associated factors of major depressive disorder (MDD) and generalized anxiety disorder (GAD) by gender in Chinese rural adults.MethodsA total of 29,993 participants aged from 18 to 79 years from the Henan Rural Cohort Study were included in this study. The Patient Health Questionnaire-2 (P...
Qi, Xiongwei Fan, Huanhuan Yang, Xiao Chen, Yayun Deng, Wei Guo, Wanjun Wang, Qiang Chen, Eric Li, Tao Ma, Xiaohong
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Published in
BMC Psychiatry
BackgroundVisual deficits have been reported in abundance by recent studies on major depressive disorder. Pattern glare manifests as visual distortions, such as the symptoms of headache, glare, eyestrain, illusions of shapes, colors, and motion when viewing repetitive striped patterns, of which some can be observed in major depressive disorder. Ins...
van Kleef, Rozemarijn S. Bockting, Claudi L. H. van Valen, Evelien Aleman, André Marsman, Jan-Bernard C. van Tol, Marie-José
Published in
BMC Psychiatry
BackgroundMajor Depressive Disorder (MDD) is a psychiatric disorder with a highly recurrent character, making prevention of relapse an important clinical goal. Preventive Cognitive Therapy (PCT) has been proven effective in preventing relapse, though not for every patient. A better understanding of relapse vulnerability and working mechanisms of pr...
Armenta, Richard F. Walter, Kristen H. Geronimo-Hara, Toni Rose Porter, Ben Stander, Valerie A. LeardMann, Cynthia A. Bauer, Lauren Boparai, Satbir Bukowinski, Ania Carballo, Carlos
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Published in
BMC Psychiatry
BackgroundPosttraumatic stress disorder (PTSD) often co-occurs with other psychiatric disorders, particularly major depressive disorder (MDD). The current study examined longitudinal trajectories of PTSD and MDD symptoms among service members and veterans with comorbid PTSD/MDD.MethodsEligible participants (n = 1704) for the Millennium Cohort Study...
Kim, Eun Young Kim, Se Hyun Lee, Hyun Jeong Lee, Nam Young Kim, Hye Young Park, C Hyung Keun Ahn, Yong Min
Published in
Journal of affective disorders
Escalating doses of selective serotonin reuptake inhibitors are often used to treat patients with a suboptimal response to the standard dose. This study assessed the efficacy and safety of dose escalation of escitalopram, up to 30 mg, in non-remitters with major depressive disorder (MDD) after treatment with the standard dose. We recruited 98 patie...
