Lu, Xiang Zhang, Jian-Feng Gu, Feng Zhang, Hong-Xing Zhang, Meng Zhang, Hai-San Song, Rui-Ze Shi, Ya-Chen Li, Kun Wang, Bi
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Published in
Journal of affective disorders
Altered global signal (GS) topography features in the resting-state fMRI of major depressive disorder (MDD), showing abnormally strong global signal representation in the default-mode network (DMN). Whether the abnormal local to global change also shapes activity during task states, and how it relates to psychopathological symptoms, e.g., abnormall...
Zhang, Huifeng Wu, Zhiguo Cao, Lan Su, Yousong Wang, Fan Hong, Wu Cai, Yiyun Peng, Daihui Fang, Yiru
Published in
Journal of affective disorders
In spite of numerous options, the most efficacious treatment for major depressive disorder (MDD) remains elusive. Algorithm-guided treatments (AGTs) are proposed to address inadequate remission and optimize treatment delivery. This study aimed to evaluate the clinical benefit of AGTs for MDD, and to explore specific moderators of treatment outcomes...
Maziade, M Bureau, A Jomphe, V Gagné, A M
Published in
Progress in neuro-psychopharmacology & biological psychiatry
The millions of children having a parent affected by a major psychiatric disorder may carry, as vulnerability indicators, electroretinographic (ERG) anomalies resembling those seen in adult patients. Our goal was to determine whether ERG anomalies in high-risk youths are related to clinical precursors of a later transition to illness such as the pr...
Lampit, Amit Launder, Nathalie H. Minkov, Ruth Rollini, Alice Davey, Christopher G. Finke, Carsten Lautenschlager, Nicola T. Gavelin, Hanna Malmberg
Published in
Systematic Reviews
BackgroundPeople with depression often present with concurrent cognitive impairment. Computerized cognitive training (CCT) is a safe and efficacious strategy to maintain or enhance cognitive performance in a range of clinical populations. However, its efficacy in people with depression and how it varies across populations and design factors are cur...
Furihata, Ryuji Otsuki, Rei Hasegawa, Naomi Tsuboi, Takashi Numata, Shusuke Yasui-Furukori, Norio Kashiwagi, Hiroko Hori, Hikaru Ochi, Shinichiro Muraoka, Hiroyuki
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[Study objectives] To investigate the proportion of inpatients with schizophrenia and major depressive disorder prescribed hypnotic medication, and the association between such medication and the use of other antipsychotic agents. [Methods] This was a nationwide cross-sectional study performed as part of the ‘Effectiveness of Guidelines for Dissemi...
Peng, Rui Wang, Yongshi Huang, Yueqin Liu, Zhaorui Xu, Xiangdong Ma, Yanjuan Wang, Limin Zhang, Mei Yan, Yongping Wang, Bo
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Published in
Journal of affective disorders
The symptoms that patients with major depressive disorder (MDD) experience are the dominant contributing factors to its heavy disease burden. This study sought to identify key symptoms leading to disability in patients with MDD. Subjects consisted of patients who had a 12-month MDD diagnosis based on the China Mental Health Survey (CMHS). World Hea...
Chrysikou, Evangelia G Wing, Erik K van Dam, Wessel O
Published in
Biological psychiatry. Cognitive neuroscience and neuroimaging
A well-established impaired top-down network for effortful emotion regulation (ER) in major depressive disorder (MDD) includes the dorsal and ventromedial prefrontal cortex (PFC) and the amygdala. Transcranial direct current stimulation (tDCS) is a noninvasive neuromodulation method that has been used successfully to induce mood changes in MDD. Des...
Blokland, Gabriëlla A M Grove, Jakob Chen, Chia-Yen Cotsapas, Chris Tobet, Stuart Handa, Robert St Clair, David Lencz, Todd Mowry, Bryan J Periyasamy, Sathish
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Published in
Biological psychiatry
Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. We conducted the largest to date genome-wide gen...
Clark, Samuel David
Published in
Handbook of experimental pharmacology
The kappa opioid receptor (KOR) and its endogenous ligands dynorphins (DYN) have been implicated in the development or symptomatology of a variety of neuropsychiatric disorders. This review covers a brief history of the development of KOR agonists and antagonists, their effects in healthy volunteers, and the potential role of DYN/KOR dysfunction in...
van der Zee, Yentl Y Lardner, Casey K Parise, Eric M Mews, Philipp Ramakrishnan, Aarthi Patel, Vishwendra Teague, Collin D Salery, Marine Walker, Deena M Browne, Caleb J
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Published in
Biological psychiatry
Major depressive disorder is a pervasive and debilitating syndrome characterized by mood disturbances, anhedonia, and alterations in cognition. While the prevalence of major depressive disorder is twice as high for women as men, little is known about the molecular mechanisms that drive sex differences in depression susceptibility. We discovered tha...
