Li, Xinyan Li, Na Han, Yingnan Rao, Kaifeng Ji, Xiaoya Ma, Mei
Published in
Environmental pollution (Barking, Essex : 1987)
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a well-known immunotoxic environmental pollutant. However, most immunotoxicology studies of TCDD were based on the animal models and the inner mechanisms have just focused on a few genes/proteins. In this study, the immune functions of THP-1-derived macrophages was measured with in-vitro bioassays after...
Zhao, Yang Chang, Ziyi Zhao, Guizhen Lu, Haocheng Xiong, Wenhao Liang, Wenying Wang, Huilun Villacorta, Luis Garcia-Barrio, Minerva T Zhu, Tianqing
...
Published in
Cardiovascular drugs and therapy
Abdominal aortic aneurysm (AAA) is one of the leading causes of death in the developed world and is currently undertreated due to the complicated nature of the disease. Herein, we aimed to address the therapeutic potential of a novel class of pleiotropic mediators, specifically a new drug candidate, nitro-oleic acid (NO2-OA), on AAA, in a well-char...
Nojiri, Shunsuke Tsuchiya, Atsunori Natsui, Kazuki Takeuchi, Suguru Watanabe, Takayuki Kojima, Yuichi Watanabe, Yusuke Kamimura, Hiroteru Ogawa, Masahiro Motegi, Satoko
...
Published in
Inflammation and Regeneration
The liver has a high regenerative ability and can induce spontaneous regression of fibrosis when early liver damage occurs; however, these abilities are lost when chronic liver damage results in decompensated cirrhosis. Cell therapies, such as mesenchymal stem cell (MSC) and macrophage therapies, have attracted attention as potential strategies for...
Ho, Dung Thi Pham, Hung Hoang Son Aota, Wataru Matsubayashi, Makoto Tsuji, Naotoshi Hatabu, Toshimitsu
This study aimed to evaluate the disease severity and local immune responses in macrophage-depleted chicks with Eimeria tenella. Macrophages were reduced by intraperitoneal injection of a carrageenan solution at 12, 13, and 16 days old, whereas the control group received intraperitoneal phosphate-buffered saline. Both chick groups were orally inocu...
Huang, Yihua Yang, Xue Meng, Yan Shao, Changchun Liao, Jianping Li, Fengwei Li, Rong Jing, Yingying Huang, Aimin
Published in
Cell & Bioscience
Background Liver cancer is one of the most common malignancies in the world with a poor prognosis. Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, accounting for 80–90% of cases. The initiation and progression of HCC are closely associated with chronic liver inflammation. In addition, HCC is often accompanied by cell sene...
Terai, Shuji Tsuchiya, Atsunori Watanabe, Yusuke Takeuchi, Suguru
Published in
Inflammation and Regeneration
The liver is a highly regenerative organ; however, its regeneration potential is reduced by chronic inflammation with fibrosis accumulation, leading to cirrhosis. With an aim to tackle liver cirrhosis, a life-threatening disease, trials of autologous bone marrow cell infusion (ABM i ) therapy started in 2003. Clinical studies revealed that ABM i at...
Ma, Xue Qin, Chuan Chen, Man Yu, Hai-Han Chu, Yun-Hui Chen, Ting-Jun Bosco, Dale B. Wu, Long-Jun Bu, Bi-Tao Wang, Wei
...
Published in
Journal of Neuroinflammation
Background and purpose Neuromyelitis optica spectrum disorder (NMOSD) is mainly an anti-aquaporin 4 (anti-AQP4) autoantibodies-mediated idiopathic inflammatory demyelinating disease of the central nervous system. Systemic and local inflammatory responses play a key role in the pathophysiology of NMOSD. However, the role of the crucial immunomodulat...
Sun, Jennifer Chen, Yixuan Lubben, Berit Adebayo, Ola Muz, Barbara Azab, Abdel Kareem
Published in
Leukemia Research Reports
CD47 is a surface glycoprotein expressed by host cells to impede phagocytosis upon binding to macrophage SIRPα, thereby represents an immune checkpoint known as the “don't-eat-me” signal. However, accumulating evidence shows that solid and hematologic tumor cells overexpress CD47 to escape immune surveillance. Thus, targeting the CD47-SIRPa axis by...
Mompart, Florence Kamgoué, Alain Lahbib-Mansais, Yvette Robelin, David Bonnet, Agnès Rogel-Gaillard, Claire Kocanova, Silvia Yerle-Bouissou, Martine
Published in
BMC Molecular and Cell Biology
Background The crucial role of the major histocompatibility complex (MHC) for the immune response to infectious diseases is well-known, but no information is available on the 3D nuclear organization of this gene-dense region in immune cells, whereas nuclear architecture is known to play an essential role on genome function regulation. We analyzed t...
de Oliveira, Salmo Azambuja Cerri, Paulo Sérgio Sasso-Cerri, Estela
Published in
Histochemistry and Cell Biology
The role of cytokines in testicular function under normal conditions has not been completely understood. Here, we evaluated testicular macrophages (TM), steroidogenesis by Leydig cells (LC) and seminiferous tubules integrity in cytokines-deficient rat testes induced by diacerein, an anti-inflammatory drug that inhibits interleukin-1 (IL-1) and tumo...
