Park, In-Byung Choi, Yong-Chan Lee, Kyung-Tai Chun, Taehoon
Published in
Veterinary immunology and immunopathology
Porcine reproductive and respiratory syndrome virus (PRRSV) is a causative pathogen of PRRS, one of the most economically disastrous swine diseases. Non-structural protein 1 (NSP1) of PRRSV consists of NSP1α and NSP1β which exhibit papain like cysteine protease activity. Recent evidence demonstrates that PRRSV NSP1 may be participated in modulating...
Guo, Lina Chen, Yang Wang, Ting Yuan, Yu Yang, Yihua Luo, Xiaoli Hu, Shuo Ding, Jinsong Zhou, Wenhu
Published in
Journal of controlled release : official journal of the Controlled Release Society
Methotrexate (MTX) has been used as an anchor drug for the treatment of rheumatoid arthritis (RA), while the patients with chronic MTX administration suffer from severe side-effects. To this end, targeted delivery of MTX by nanomedicine has attracted great interest. In this work, we aimed to employ metal-organic frameworks (MOFs) as nanocarrier to ...
Mirkasymov, Aziz B Zelepukin, Ivan V Nikitin, Petr I Nikitin, Maxim P Deyev, Sergey M
Published in
Journal of controlled release : official journal of the Controlled Release Society
Smart nanomaterials, contrast nanoparticles and drug nanocarriers of advanced targeting architecture were designed for various biomedical applications. Most of such agents demonstrate poor pharmacokinetics in vivo due to rapid elimination from the bloodstream by cells of the mononuclear phagocyte system (MPS). One of the promising methods to prolon...
Yue, Lei Yan, Min Chen, Shihua Cao, Han Li, Hua Xie, Zhongping
Published in
Biochemical and biophysical research communications
Pseudomonas aeruginosa is the main conditional pathogen of immunodeficiency individuals. The mechanisms governing immune response to P. aeruginosa infection by macrophages remain incompletely defined. Herein, we demonstrate that protein tyrosine phosphatase-1B (PTP1B) is a critical negative regulator of P. aeruginosa infection response by macrophag...
Härdtner, Carmen Kornemann, Jan Krebs, Katja Ehlert, Carolin A. Jander, Alina Zou, Jiadai Starz, Christopher Rauterberg, Simon Sharipova, Diana Dufner, Bianca
...
Published in
Basic Research in Cardiology
Statins induce plaque regression characterized by reduced macrophage content in humans, but the underlying mechanisms remain speculative. Studying the translational APOE*3-Leiden.CETP mouse model with a humanized lipoprotein metabolism, we find that systemic cholesterol lowering by oral atorvastatin or dietary restriction inhibits monocyte infiltra...
Wolf, Julian Zhuang, Xinyu Hildebrand, Antonia Boneva, Stefaniya Schwämmle, Melanie Kammrath Betancor, Paola Fan, Jiaqi Böhringer, Daniel Maier, Philip Lange, Clemens
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Published in
Molecular immunology
Immune reactions following corneal transplantation are the most common cause of transplant failure. However, the underlying mechanisms of corneal graft rejection are not yet fully understood but increasing evidence points to a crucial role of the innate immune system in this context. Using a human in vitro model, we aimed to assess the response of ...
Lontchi-Yimagou, Eric Kang, Sona Goyal, Akankasha Zhang, Kehao You, Jee Y Carey, Michelle Jain, Swati Bhansali, Shobhit Kehlenbrink, Sylvia Guo, Peng
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Published in
Molecular metabolism
Adipose tissue inflammation and fibrosis appear to contribute to insulin resistance in obesity. Vitamin D receptor (Vdr) genes are expressed by adipocytes, macrophages, and fibroblasts, all of which could potentially play a role in adipose tissue inflammation and fibrosis. As vitamin D has been shown to have direct anti-inflammatory effects on adip...
Liu, Yanwei Liu, Zhongyong
Published in
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
To assess the effect of Jianpi Huazhuo Tiaozhi granules (JHTG) on oxidative stress damage to macrophages and explore the relationship between the levels of this damage and the nicotinamide adenine dinucleotide phosphate oxidase (NOX)/reactive oxygen species (ROS)- nuclear transcription factor kappa B (NF-κB) signaling pathway. Macrophages cultured ...
Lee, Dae-Hyo Park, Jeong-Ki Choi, Jawun Jang, Hyuk Seol, Jae-Won
Published in
International immunopharmacology
Diosmetin, a citrus flavonoid, has a variety of therapeutic properties such as antibacterial, anti-inflammatory and antioxidant effects. However, the effect of diosmetin on atopic dermatitis (AD) development has not been reported. This study thus aims to investigate whether diosmetin possesses inhibitory effects on AD development. A dinitrochlorobe...
Hu, Xintong Gu, Yue Zhao, Songchen Hua, Shucheng Jiang, Yanfang
Published in
Cancer immunology, immunotherapy : CII
There are significant differences in pathology, etiology, clinical features, and treatment options between small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). However, the differences of macrophage distribution and its associated function between SCLC and NSCLC are not fully investigated. Through methods of flow cytometry and cyto...
