Non-viral vectors represent versatile and immunologically safer alternatives for nucleic acid delivery. Nanoneedles and high-aspect ratio nanostructures are unconventional but interesting delivery systems, in which delivery is mediated by surface interactions. Herein, nanoneedles are synergistically combined with polysaccharide-polyplex nanofilms a...
Encapsulation of cells has been an active area of research. Among various methods for encapsulation, Layer-by-Layer (LbL) offers extensive flexibility in the design of surfaces and their interfacial nanoarchitectonics. A diverse range of functionalities have been recently demonstrated for cell encapsulation including protection and improved circula...
10.1039/c9ee03046h / Energy and Environmental Science / 13 / 3 / 685-743
While DNA and messenger RNA (mRNA) based therapies are currently changing the biomedical field, the delivery of genetic materials remains the key problem preventing the wide introduction of these methods into clinical practice. Therefore, the creation of new methods for intracellular gene delivery, particularly to hard-to-transfect, clinically rele...
In order to enhance the thermal stability and thermochromic properties, three kinds of VOx-based thin films with different structures (single-layer, triple-layer and multi-layer, respectively) were designed in this study. All of them were prepared by room-temperature reactive magnetron sputtering and subsequently rapid thermal annealing (RTA) in ni...
Polyelectrolyte microcapsules represent a versatile platform to encapsulate and release active ingredients. Understanding the effect of environmental conditions on the mechanical properties of microcapsules is critically important for enabling their applications under various settings. In this report, we investigate the effect of solution pH on the...
Published in Advanced materials (Deerfield Beach, Fla.)
The direct local delivery of short interfering RNA (siRNA) into target tissues presents a real solution to several complex medical conditions that today lack efficacious therapies. The development of an ultrathin polymer coating is described to sustain the delivery of siRNA for up to 2 weeks in vitro and in vivo. This technology successfully reduce...
Layer-by-layer deposition is a widely used method for surface functionalization. It is shown here that up to 58 covalently linked molecular layers could be assembled in 20 mm at room temperature on a silicon wafer by the layer-by-layer click reaction of a divalent triazolinedione and a trivalent diene. The layer growth was found to be linear. The m...
Layer by Layer (LbL) thin films stemming from the formation of stereocomplex between oligolactate of opposite chirality (OLLA and ODLA) covalently anchored onto poly(vinyl alcohol) (PVA) chains is described herein for the first time. The feasibility to construct films by sequential adsorption of PVA-g-ODLA and PVA-g-OLLA graft copolymers is underta...
Recently, researchers spare no efforts to fabricate desirable vanadium dioxide (VO2) film which provides simultaneously high luminous transmittance and outstanding solar modulation ability, yet progress towards the optimization of one aspect always comes at the expense of the other. Our research devotes to finding a reproducible economic solution-p...
