Poucineau, Jonas Khlat, Myriam Lapidus, Nathanaël Chouaïd, Christos Espagnacq, Maude Delory, Tristan Le Coeur, Sophie
Background During the first wave of the COVID-19 pandemic, a reduction in the number of newly diagnosed cases of lung cancer has been reported worldwide, often associated with a higher proportion of cases diagnosed at an advanced stage compared with previous years. Methods Using the French National Hospital Database, we investigated incident lung c...
Liu, Jinping; Zhang, Tongchang; Ren, Yanqun; Willems, Patrick; 9249; Mirchi, Ali; Arshad, Arfan; Liu, Tie; Pham, Quoc Bao;
status: accepted
Merville, Ophélie Bonnet, Florian Launoy, Guy Camarda, Carlo Giovanni Cambois, Emmanuelle
The growth in life expectancy (LE) slows down recently in several high-income countries. Among the underlying dynamics, uneven progress in LE across social groups has been pointed out. However, these dynamics has not been extensively studied, partly due to data limitations. In this paper, we explore this area for the 2010 decade using recent French...
Schreiber, Stefan; Cross, Raymond K.; Panaccione, Remo; D'Haens, Geert; Bossuyt, Peter; Dotan, Iris; Colombel, Jean-Frederic; Louis, Edouard; Dubinsky, Marla C.; Kligys, Kristina;
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BACKGROUND: Risankizumab is efficacious and well tolerated in adults with moderately to severely active Crohn's disease (CD). AIM: To evaluate the corticosteroid-sparing effect of risankizumab in CD. METHODS: During the 12-week induction period, patients maintained stable baseline corticosteroid doses, up to 20 mg/day prednisone or equivalent. At w...
Kwong, Fong Lien Audrey; Kristunas, Caroline; Davenport, Clare; Deeks, Jon; Mallett, Sue; Agarwal, Ridhi; Kehoe, Sean; Timmerman, Dirk; 17301; Bourne, Tom; 56124; Stobart, Hilary;
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OBJECTIVE: Symptom-triggered testing for ovarian cancer was introduced to the UK whereby symptomatic women undergo an ultrasound scan and serum CA125, and are referred to hospital within 2 weeks if these are abnormal. The potential value of symptom-triggered testing in the detection of early-stage disease or low tumor burden remains unclear in wome...
Grigoriev, Pavel Levchuk, Nataliia Shevchuk, Pavlo Poniakina, Svitlana Klüsener, Sebastian
Turbulent socio-economic development, recent political challenges, and remarkable regional diversity with deep historical roots make Ukraine an important case study for understanding mortality trends in Eastern Europe. In this paper, we provide the first comprehensive, spatially detailed analysis of cause-specific mortality trends and patterns in U...
Poucineau, Jonas
La pandémie de Covid-19 a conduit à une réorganisation de l’offre de soins en France, avec des conséquences sur le recours aux soins et la santé des patients atteints de pathologies chroniques. Cette thèse consiste à analyser, à partir des données médico- administratives du Système national des données de santé (SNDS), les effets directs et indirec...
Baum, Philip; Cardoso, Rafael; Lenzi, Jacopo; Damhuis, Ronald A.M.; Verhagen, Ad F.T.M.; De Gendt, Cindy; Peacock, Hanna; De Leyn, Paul; 7818; Christensen, Niels L.; Innos, Kaire;
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OBJECTIVE: Harmonized European NSCLC incidence, treatment approach, and survival based on national tumor registries are unclear. SUMMARY BACKGROUND DATA: Surgery has the potential to cure NSCLC and significantly prolong survival. This large-scale international study aimed to investigate treatment variations in Europe and the USA, as well as the det...
Huybregts, Jeroen G.J.; Polak, Samuel B.; Jacobs, Wilco C.; Arts, Mark P.; Meyer, Bernhard; Wostrack, Maria; Butenschoen, Vicki M.; Osti, Michael; Oner, F. Cumhur; Slooff, Willem-Bart M.;
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BACKGROUND: The optimal treatment for odontoid fractures in older people remains debated. Odontoid fractures are increasingly relevant to clinical practice due to ageing of the population. METHODS: An international prospective comparative study was conducted in fifteen European centres, involving patients aged ≥55 years with type II/III odontoid fr...
Burmester, Gerd R.; Gottenberg, Jacques-Eric; Caporali, Roberto; Winthrop, Kevin L.; Tanaka, Yoshiya; Omoruyi, Edmund V. Ekoka; Rajendran, Vijay; Van Hoek, Paul; Van Beneden, Katrien; Takeuchi, Tsutomu;
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OBJECTIVES: To update the long-term safety profile of filgotinib, a Janus kinase-1 preferential inhibitor, in patients with moderate-to-severe rheumatoid arthritis. METHODS: Data from seven trials were integrated (NCT01888874, NCT01894516, NCT02889796, NCT02873936, NCT02886728, NCT02065700 and NCT03025308). Patients received once-daily filgotinib 1...
